A5023231177- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Estrogen and related hormone effects
- Neuroscience and Neuropharmacology Research
- Menopause: Health Impacts and Treatments
- Nerve injury and regeneration
- Receptor Mechanisms and Signaling
- Nuclear Receptors and Signaling
- Gestational Diabetes Research and Management
- Metabolism, Diabetes, and Cancer
- Phytoestrogen effects and research
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
- TGF-β signaling in diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- PI3K/AKT/mTOR signaling in cancer
- Neurological Disorders and Treatments
- Dysphagia Assessment and Management
- Coronary Artery Anomalies
- Congenital heart defects research
- Protein Tyrosine Phosphatases
- Nicotinic Acetylcholine Receptors Study
- Cancer-related Molecular Pathways
- Redox biology and oxidative stress
Beijing Children’s Hospital
2020
Capital Medical University
2020
Chang Gung University of Science and Technology
2019
University of North Texas Health Science Center
2005-2018
University of North Texas
2005-2018
Fourth Affiliated Hospital of Anhui Medical University
2018
Anhui Medical University
2018
Harbin Medical University
2018
Cotton Research Institute
2013
Osaka City University
2012
Differentiated vascular smooth muscle cells (SMCs) exhibit a work phenotype characterized by expression of several well documented contractile apparatus-associated proteins. However, SMCs retain the ability to de-differentiate into proliferative phenotype, which is involved in progression diseases such as atherosclerosis and restenosis. Understanding mechanisms maintaining SMC differentiation critical for preventing proliferation associated with disease. In this study, molecular through...
Progesterone (P4) is cytoprotective in various experimental models, but our understanding of the mechanisms involved still incomplete. Our laboratory has implicated brain-derived neurotrophic factor (BDNF) signaling as an important mediator P4's protective actions. We have shown that P4 increases expression BDNF, effect mediated by classical receptor (PR), and effects were abolished using inhibitors Trk signaling. In effort to extend interrelationship between BDNF signaling, we determined...
This study was conducted to investigate the possible involvement of vascular renin-angiotensin system in isoproterenol (ISO)-induced facilitation adrenergic neurotransmission mesenteric vasculature. The isolated, perfused beds from normotensive Wistar Kyoto rats (WKY) and spontaneously hypertensive (SHR) were used for these studies. ISO at concentrations 10(-9) 10(-6) M caused significantly greater enhancement pressor response periarterial nerve stimulation (PNS) preparations SHR than those...
Males have a higher risk for developing Parkinson's disease and parkinsonism after ischemic stroke than females. Although estrogens been shown to play neuroprotective role in disease, there is little information on androgens' actions dopamine neurons. In this study, we examined the effects of androgens under conditions oxidative stress determine whether or neurotoxic neuronal function. Mitochondrial function, cell viability, intracellular calcium levels, mitochondrial influx were response...
Parkinson's disease, a progressive neurodegenerative disorder, is associated with oxidative stress and neuroinflammation. These pathological markers can contribute to the loss of dopamine neurons in midbrain. Interestingly, men have 2-fold increased incidence for disease than women. Although mechanisms underlying this sex difference remain elusive, we propose that primary male hormone, testosterone, involved. Our previous studies show through putative membrane androgen receptor, increase...
Background and Purpose Cognitive deficits in patients with A lzheimer's disease, P arkinson's traumatic brain injury stroke often involve alterations cholinergic signalling. Currently available therapeutic drugs provide only symptomatic relief. Therefore, novel strategies are needed to retard and/or arrest the progressive loss of memory. Experimental Approach Scopolamine‐induced memory impairment provides a rapid reversible phenotypic screening paradigm for cognition enhancement drug...
Abstract Neurotrophins play essential roles in the development, differentiation, and survival of neuronal nonneuronal cells. Alterations neurotrophin expression have been implicated a variety neurodegenerative disorders. Dysregulation brain‐derived neurotrophic factor (BDNF) has deficits long‐term potentiation cognition may contribute to development Alzheimer's disease (AD). In this study, we used complementary pharmacological molecular approaches evaluate role ERK1/2 ERK5, two members MAPK...
Abstract Progesterone (P4) exerts robust cytoprotection in brain slice cultures (containing both neurons and glia), yet such protection is not as evident neuron-enriched cultures, suggesting that glia may play an indispensable role P4's neuroprotection. We previously reported a membrane-associated P4 receptor, receptor membrane component 1, mediates P4-induced brain-derived neurotrophic factor (BDNF) release from glia. Here, we sought to determine whether are required for neuroprotection...
Significance Pgrmc1 plays an important role in mediating progesterone’s protective effects that it is a critical mediator of progesterone-induced BDNF release. Here, we identified the microRNA let-7i , which increased stroke, as negative regulator and expression. Conversely, inhibition enhanced against stroke. In addition to enhancing neuroprotective effects, fact also diminishes expression suggests may be useful any intervention targets enhancement signaling and, such, relevant treatment...
To date many aspects of neurons and glia biology remain elusive, due in part to the cellular molecular complexity brain.In recent decades, cell models from different brain areas have been established proven invaluable toward understanding this complexity.In field steroid hormone neurobiology, an important question is: what is profile receptor expression these specific lines?Currently, a clear summary such profiling lacking.For reason, we summarized review estrogen, progesterone, androgen...
To investigate the prevalence and genetic characteristics of myotonic dystrophy type 1 (DM1) in Taiwan, DM-suspected patients their families identified during period 1990–2001 had clinical records reevaluated CTG repeat sizes at DM1 locus examined. A total 96 subjects belonging to 26 were as patients, which gave a minimal disease 0.46/100,000 inhabitants. Clinical anticipation was frequently observed affected families, even some parent-child pairs with transmission contraction size. The...
AbstractThe transition of vascular smooth muscle cells (VSMCs) from G2 phase into the M (mitosis) cell cycle is a tightly controlled process. As an arterial SMC prepares for G2/M transition, has primed Cdc2/cyclinB1 complex activation by phosphorylation threonine-161 residue on Cdc2. This necessary but not sufficient VSMC to enter phase. In order mitosis, phosphatase, Cdc25C, must first dephosphorylate two other critical residues: tyrosine-15 and threonine-14. If Cdc25C phosphatase activity...
Forty core primers were used to construct a DNA fingerprint database of 132 cotton species based on multiplex fluorescence detection technology.A high first successful ratio 99.04% was demonstrated with tetraplex polymerase chain reaction.Forty primer pairs amplified total 262 genotypes among species, an average 6.55 per and values polymorphism information content varying from 0.340 0.882.Conflicting homozygous ratios found in various species.The highest landrace standard cultivars, which...
When iodine intake is in excess, a susceptible population that has genetic predisposition will have an increased risk of hypothyroidism or autoimmune thyroiditis. This study evaluated the vulnerability to excess and subclinical thyroid disease through screening single nucleotide polymorphisms (SNPs) reproductive-age women provide evidence be used for prevention disease.In Shanxi province, four areas where range exposures from low high were chosen each region, 60 anticipated enrol, including...