A5085597666- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Pharmacological Receptor Mechanisms and Effects
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Neuroendocrine regulation and behavior
- Ion channel regulation and function
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Child and Adolescent Psychosocial and Emotional Development
- Neuropeptides and Animal Physiology
- Obsessive-Compulsive Spectrum Disorders
- Heavy Metal Exposure and Toxicity
- Nicotinic Acetylcholine Receptors Study
- Memory and Neural Mechanisms
- Mitochondrial Function and Pathology
- GDF15 and Related Biomarkers
- Attention Deficit Hyperactivity Disorder
- Adipose Tissue and Metabolism
- Cannabis and Cannabinoid Research
Indiana University – Purdue University Indianapolis
2020-2024
Indiana University School of Medicine
2023-2024
Indianapolis Zoo
2024
Neurosciences Institute
2024
Indiana University
2018-2023
Indiana University Bloomington
2014-2023
University School
2023
University of Indianapolis
2021
University of North Texas
2014-2016
University of North Texas Health Science Center
2014-2016
Abstract INTRODUCTION MODEL‐AD (Model Organism Development and Evaluation for Late‐Onset Alzheimer's Disease) is creating distributing novel mouse models with humanized, clinically relevant genetic risk factors to capture the trajectory progression of late‐onset disease (LOAD) more accurately. METHODS We created LOAD2 model by combining apolipoprotein E4 (APOE4), Trem2*R47H, humanized amyloid‐beta (Aβ). Mice were subjected a control diet or high‐fat/high‐sugar (LOAD2+HFD). assessed...
Abstract Women are twice as likely men to experience emotional dysregulation after stress, resulting in substantially higher psychopathology for equivalent lifetime stress exposure, yet the mechanisms underlying this vulnerability remain unknown. Studies suggest changes medial prefrontal cortex (mPFC) activity a potential contributor. Whether maladaptive inhibitory interneurons participate process, and whether adaptations response differ between women, producing sex-specific behaviors mPFC...
Background and Purpose Cognitive deficits in patients with A lzheimer's disease, P arkinson's traumatic brain injury stroke often involve alterations cholinergic signalling. Currently available therapeutic drugs provide only symptomatic relief. Therefore, novel strategies are needed to retard and/or arrest the progressive loss of memory. Experimental Approach Scopolamine‐induced memory impairment provides a rapid reversible phenotypic screening paradigm for cognition enhancement drug...
Abstract Glutamate signalling through the N ‐methyl‐ d ‐aspartate receptor (NMDAR) activates enzyme neuronal nitric oxide synthase (nNOS) to produce molecule (NO). We hypothesized that disruption of protein–protein interaction between nNOS and scaffolding protein postsynaptic density 95 kDa (PSD95) would block NMDAR‐dependent NO represent a viable therapeutic route decrease opioid reward relapse‐like behaviour without unwanted side effects NMDAR antagonists. used conditioned place preference...
Blockade of cannabinoid type 1 (CB1)-receptor signaling decreases the rewarding properties many drugs abuse and has been proposed as an anti-addiction strategy. However, psychiatric side-effects limit clinical potential orthosteric CB1 antagonists. Negative allosteric modulators (NAMs) represent a novel indirect approach to attenuate by decreasing affinity and/or efficacy ligands. We hypothesized that CB1-NAM would block opioid reward while avoiding unwanted effects GAT358, CB1-NAM, failed...
Abstract Abnormal gamma band power across cortex and striatum is an important phenotype of Huntington’s disease (HD) in both patients animal models, but neither the origin nor functional relevance this well understood. Here, we analyzed local field potential (LFP) activity freely behaving, symptomatic R6/2 Q175 mouse models corresponding wild-type (WT) controls. We focused on periods quiet rest, which show strong γ HD mice. Simultaneous recording from motor its target area dorsal model...
Abstract LS‐3‐134 is a substituted N ‐phenylpiperazine derivative that has been reported to exhibit: (i) high‐affinity binding ( K i value 0.2 nM) at human D3 dopamine receptors, (ii) > 100‐fold versus D2 receptor subtype selectivity, and (iii) low‐affinity 5000 sigma 1 2 receptors. Based upon forskolin‐dependent activation of the adenylyl cyclase inhibition assay, weak partial agonist both subtypes (29% 35% full activity, respectively). In this study, [ 3 H]‐labeled was prepared...
MODEL-AD is creating and distributing novel mouse models with humanized, clinically relevant genetic risk factors to more accurately mimic LOAD than commonly used transgenic models.
Medium spiny neurons (MSNs) comprise over 90% of cells in the striatum. In vivo MSNs display coherent burst firing cell assembly activity patterns, even though isolated do not fire intrinsically. This is important for learning and execution action sequences characteristically dysregulated Huntington's Disease (HD). However, how dysregulation caused by various neural pathologies affecting HD unknown. Previous modeling work using simple models has shown that patterns can emerge as a result MSN...
Extensive damage to nigrostriatal dopaminergic neurons leads Parkinson’s disease (PD). To date, the most effective treatment has been administration of levodopa (L-DOPA) increase tone. This responses that vary widely among patients, from predominantly beneficial effects induction disabling, abnormal movements (L-DOPA induced dyskinesia (LID)). Similarly, experimental studies have shown animals with different degrees LID severity. In this study, unilateral injections 6-hydroxydopamine...