A5031846477- Cellular Mechanics and Interactions
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Ion channel regulation and function
- Neuroendocrine regulation and behavior
- Cancer, Hypoxia, and Metabolism
- Cardiac electrophysiology and arrhythmias
- Cancer Mechanisms and Therapy
- Pituitary Gland Disorders and Treatments
- Ubiquitin and proteasome pathways
- Growth Hormone and Insulin-like Growth Factors
- 3D Printing in Biomedical Research
- Stress Responses and Cortisol
- Hepatocellular Carcinoma Treatment and Prognosis
- Nerve injury and regeneration
- Barrier Structure and Function Studies
- Ion Transport and Channel Regulation
- Neurogenesis and neuroplasticity mechanisms
- FOXO transcription factor regulation
- Hypothalamic control of reproductive hormones
- Fluoride Effects and Removal
- Selenium in Biological Systems
- Cancer-related molecular mechanisms research
- Chromium effects and bioremediation
- Nuclear Receptors and Signaling
Center for Research and Advanced Studies of the National Polytechnic Institute
2006-2023
Instituto Politécnico Nacional
2007-2023
The 6-Hydroxydopamine (6-OHDA) rat model of Parkinson's disease is essential for a better understanding the pathological processes underlying human and evaluation promising therapeutic interventions. This work evaluated whether single striatal injection 6-OHDA causes progressive apoptosis dopamine (DA) neurons activation glycogen synthase kinase 3β (GSK-3β) caspase-3 in substantia nigra compacta (SNc). loss DA was shown by three neuron markers; tyrosine hydroxylase (TH), NeuN, β-III tubulin....
Sensory and social deprivation from the mother littermates during early life disturbs development of central nervous system, but little is known about its effect on peripheral system. To assess effects isolation, male rat pups were reared artificially in complete isolation (AR); with two same-age conspecifics (AR-Social); or by their mothers (MR). As adults, electrophysiological properties sensory sural (SU) nerve recorded. We found that amplitude normalized area (with respect to body...
Abstract Serotonin [5‐hydroxytryptamine (5‐HT)] modulates ovarian function. The precursor of 5‐HT, 5‐hydroxytryptophan (5‐HTP), has been used to treat depression. However, the effects 5‐HTP on and reproductive physiology remain unknown. In this research, we analysed impact monoaminergic system its interactions with axis estradiol secretion when administered by distinct routes. Female rats 30 days age were injected i.p . (100 mg/kg), into bursa (1.5 µg/40 µL) or median raphe nucleus (20...
The effects of organic and inorganic forms selenium (Se) on human cells have been extensively studied for nutritional concentrations; however, to date, little is known about the potential toxicity at supranutritional levels. In present study we determined sodium selenite (SSe) selenomethionine (SeMet) cell growth intracellular structures in lung cancer exposed Se concentrations between 0 3 mM. Our results showed that SSe affected more rapidly than SeMet (24 h 48 h, resp.). After 24 exposure...
Background/Aim: Liver cancer is one of the malignancies with highest mortality-to-incidence ratio worldwide. Therefore, novel therapeutic approaches are urgently needed. Combination therapy and drug repurposing can improve response patients to in several cancers. The aim present study was merge these two strategies evaluate whether two-drug- or three-drug- combination sorafenib, raloxifene, loratadine improves antineoplastic effect on human liver cells comparison single-drug effect....
ABSTRACT Early adverse experiences disrupt brain development and behavior, but little is known about how such impact on the of peripheral nervous system. Recently, we found alterations in electrophysiological histological characteristics sensory sural (SU) nerve maternally deprived, artificially reared (AR) adult male rats, as compared with (MR) control rats. In present study, our aim was to characterize ontogeny these alterations. Thus, pups four postnatal days (PND) were (1) AR group, (2)...
A three-dimensional culture method is described in which primary pituitary adenoma cells are grown alginate beads. Alginate a polymer derived from brown sea algae. Briefly, the tumor tissue cut into small pieces and submitted to an enzymatic digestion with collagenase trypsin. Next, cell suspension obtained. The mixed 1.2% sodium dropped CaCl2 solution, alginate/cell gelled on contact form spherical embedded beads supplied nutrients provided by media enriched 20% FBS. Three-dimensional...
Abstract The rat anterior pituitary gland undergoes changes in its cyto‐architecture during the second and third weeks of postnatal life. However, little is known about factors that regulate these tissue conformational changes. epidermal growth factor (EGF) one are synthesized by gland, almost all cells have EGF receptors (EGFR). In addition to effects on mitosis differentiation, this can modulate cell adhesion, migration, cytoskeletal organization. study we focussed our attention examining...
Activator protein 1 (AP-1) is a family of transcription factors composed Jun, Fos, activating factor (ATF), and musculoaponeurotic fibrosarcoma (MAF) homodimers heterodimers that regulate diverse cellular processes such as proliferation, apoptosis, differentiation, survival, migration. Accordingly, AP-1 plays an essential role in several diseases including cancer. During liver cancer development, abnormal activation has been implicated from initiation to progression. This review aims provide...
During the lactation period, rat pups are fed by dam, and patterns of mother-pup interaction change during this period. Additionally, there changes in feeding; first, mother´s milk is only food needed for sustenance, later, it combined with solid water. GH serum concentrations depend on both maternal-pup energy metabolism. In artificial rearing (AR) procedure, deprived interaction, feeding pattern controlled. This paradigm has been used rats to analyze effects maternal deprivation social...
Oncogenic ether à-go-go-1 (Eag1) potassium channels are overexpressed in most primary human solid tumors. Low oxygen and nutrient/growth factor concentrations play critical roles tumorigenesis. However, the mechanisms by which tumor cells survive proliferate under growth factor-depleted conditions remain elusive. Here, we investigated whether serum-deprived epidermal (EGF) regulate Eag1 expression lung breast cancer cells. The cell lines A549 MCF-7 (from lungs breast, respectively) were...
A three-dimensional culture method is described in which primary pituitary adenoma cells are grown alginate beads. Alginate a polymer derived from brown sea algae. Briefly, the tumor tissue cut into small pieces and submitted to an enzymatic digestion with collagenase trypsin. Next, cell suspension obtained. The mixed 1.2% sodium dropped CaCl2 solution, alginate/cell gelled on contact form spherical embedded beads supplied nutrients provided by media enriched 20% FBS. Three-dimensional...