A5053252031- Hypothalamic control of reproductive hormones
- Ovarian function and disorders
- Neuroendocrine regulation and behavior
- Reproductive Biology and Fertility
- Stress Responses and Cortisol
- Estrogen and related hormone effects
- Neuropeptides and Animal Physiology
- Growth Hormone and Insulin-like Growth Factors
- Circadian rhythm and melatonin
- Hormonal Regulation and Hypertension
- Reproductive Physiology in Livestock
- Birth, Development, and Health
- Hormonal and reproductive studies
- Menstrual Health and Disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Sperm and Testicular Function
- Pluripotent Stem Cells Research
- Apelin-related biomedical research
- Effects and risks of endocrine disrupting chemicals
- Ovarian cancer diagnosis and treatment
- Adipose Tissue and Metabolism
- Sexual Differentiation and Disorders
- Renal and related cancers
Universidad Nacional Autónoma de México
2014-2024
University of Minho
2024
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
1985-2016
Universidad de Zaragoza
1999-2006
Instituto Nacional de las Mujeres
2005
Seevic College
2003
Stanford University
1971-1974
Kern Medical Center
1971
Universidad de Montevideo
1967-1969
Hospital de Clínicas
1967-1968
Context.—The serotonin reuptake inhibitors are the treatment of choice for patients with obsessive-compulsive disorder; however, empirical support this assertion has been weaker children and adolescents than adults.Objective.—To evaluate safety efficacy selective inhibitor sertraline hydrochloride in disorder.Design.—Randomized, double-blind, placebo-controlled trial.Patients.—One hundred eighty-seven patients: 107 aged 6 to 12 years 80 13 17 randomized receive either (53 children, 39...
La fibra dietaria (FD) es un conjunto de polímeros carbohidratos esenciales para la salud humana presentes en alimentos origen vegetal. Su consumo mejora el tránsito intestinal y puede contribuir a reducir los niveles glucosa colesterol sangre. El objetivo este estudio fue comparar las propiedades macromoleculares funcionales soluble (FDS) e insoluble (FDI) extraída cáscara naranja por dos métodos: método ácido convencional asistido microondas, compararla con comercial. Los resultados...
Distinct luteinizing hormone receptor (LHR) protein variants exist due to the posttranslational modifications. Besides ovaries, LHR immunoreactivity (LHRI) was also found in other tissues, such as brain, fallopian tube, endometrium, trophoblast and resident tissue macrophages. The 3B5 mouse monoclonal antibody raised against purified rat LHR. In rat, porcine human identified six distinct bands migrating at ~92, 80, 68, 59, 52 48 kDa. Characteristic LHRI detected corpora lutea. During...
ABSTRACT The possible existence of peripheral asymmetry in the neuroendocrine mechanisms participating response ovary to gonadotrophins, and participation vagus nerve, was investigated. At oestrus, ovulation rate (number ovulating/number treated rats) left right unilaterally ovariectomized rats lower than that (42 vs 84%). No differences number ova shed per ovulating animal nor compensatory ovarian hypertrophy (COH) were observed. Bilateral section nerve resulted reduced COH only those...
The present study tested the hypothesis that if polycystic ovary syndrome (PCOS) results from activating noradrenergic outflow to ovary, unilaterally sectioning superior ovarian nerve (SON) will result in ovulation by denervated and restoration of progesterone (P4), testosterone (T) estradiol (E2) normal serum level. A single 2 mg dose valerate (EV) adult rats development a similar human PCOS. Ten-day old were injected with EV or vehicle solution (Vh) submitted sham surgery, unilateral...
Experiments were conducted to investigate the mechanism whereby intrapituitary implantation of crystalline estradiol benzoate (EB) on diestrus-2 advances ovulation by 1 day in rats showing 5-day estrous cycles; or 4- converted a cycle progesterone metestrus (diestrus-1). Sodium pentobarbital early afternoon following prevented advancement ovulation. It was restored 50% animals after administration submaximal dose an ovine gonadotropin releasing factor preparation. To determine required...
Abstract Background Injecting estradiol valerate (EV) to pre-pubertal or adult female rat results in effects similar those observed women with polycystic ovarian syndrome (PCOS). One of the mechanisms involved PCOS development is hyperactivity sympathetic nervous system. In EV-induced rats, unilateral sectioning superior nerve (SON) restores ovulation innervated ovary. This suggests that, addition innervation, other neural are development/maintenance PCOS. The aims present study were analyze...
Anterior pituitary (AP) glands were removed from adult female rats at different times throughout the estrous cycle, and isohormones of follicle-stimulating hormone (FSH) present within them separated by isoelectric focusing in polyacrylamide gels (PAGE-IEF; pH range 3.0–8.0). Gel eluents analyzed for FSH content radioimmunoassay (RIA) radioreceptor assay (RRA). All AP samples exhibited several peaks immunoactivity a 6.2–4.0; major peak constantly an point (p1) 4.9–4.5. To quantify...
Polycystic ovary syndrome is characterized by hyperactivity of the ovarian sympathetic nervous system, increases in content and release norepinephrine, as well decreases number β-adrenoreceptors. In present study, β-adrenoreceptors ovaries rats with polycystic were blocked analyzed resultant effects on ovulation, hormone secretion enzymes responsible for synthesis catecholamines.At 60 days age, vehicle or estradiol valerate-treated injected propranolol [10- 4 M] into bursas oestrus day. The...
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Abstract The present study analyzed the participation of left and right superior ovarian nerves (SON) in regulating progesterone, testosterone, estradiol serum levels unilaterally ovariectomized rats on each day estrous cycle. For this purpose, hormone concentrations were measured animals with either sham-surgery, unilateral ovariectomy (ULO), sectioning SON, or SON innervation situ ovary ULO. This investigation results show that ovaries have different capacities to maintain normal levels,...
In this work, a detailed anatomical description of the ovarian plexus nerve (OPN) in rats is presented. The distribution OPN was analyzed by gross anatomy; features superior mesenteric ganglion (SMG) were determined histological studies; and localization postganglionic neurons innervating ovary identified with retrograde tracer. We studied 19 adult cyclic CIIZ-V strain. found that right originates from celiac ganglion, lumbar sympathetic trunk (LGST) SMG. left LGST anastomotic branch...
The modulating effects of ovarian innervation reaching the ovary through suspensory nerve on reactivity ovaries to gonadotrophins were analysed. Juvenile rats (32 days old), with or without unilateral bilateral section superior nerve, injected 8 iu pregnant mare serum gonadotrophin (PMSG), 10 human chorionic (hCG) PMSG followed 56 h later hCG. Treatments given immediately after surgery 4 later, and killed day first vaginal oestrus. In section, treatment did not induce full ovulatory response...
ABSTRACT The effects were analysed, on ovulation at the next oestrus, of unilaterally implanting atropine in anterior hypothalamus rats each day oestrous cycle. Implantation 1 dioestrus either side blocked ovulation. left 2 all animals, whereas implantation right allowed 71% animals to ovulate (0/4 vs 5/7; P < 0·05). pro-oestrus did not modify rate When was carried out oestrus right, none ovulated, but ovulated when implant (0/8 8/8; 0·01). results suggest existence a cholinergic...
Abstract Bilateral ovariectomy or adrenalectomy are experimental tools used to understand the mechanisms regulating hypothalamus-pituitary-ovarian and hypothalamus-pituitary-adrenal axis. There is evidence that acute unilateral perforation of dorsal peritoneum in rats results significant changes progesterone, testosterone estradiol serum concentrations. Because different surgical approaches for bilateral adrenalectomy, sectioning superior ovarian nerve vagus used, we compare effects on...
Adult and prepuberal female rats were hemispayed autografted (s.c. or i.m.). None of the autografts exhibited signsof ovulation. The ovary insitu showed a compensatory hypertrophy normal In in which both ovaries with 2 1 isografted ovary, all ovulatcd normally. These results refute hypothesis that antiovary-antibodies disparity gonadotrophin/ovarian mass is responsible for failure possibility peripheral nervous system can play some role mechanism ovulation regulation gonadotrophins discussed.
ABSTRACT Anterior pituitary glands were removed from male rats at 5, 10, 15, 18, 21, 28, 30, 40, 45, 50 and 90 days of age, the multiple forms FSH present within them separated by polyacrylamide gel–isoelectric focusing (PAGE–IEF; pH range 3·0–8·0). Gel eluents analysed for content radioimmunoassay (RIA) a specific radioreceptor assay (RRA). All pituitaries studied exhibited one or more peaks immunoactive 7·0–3·0; major peak an isoelectric point (pi) 4·9–4·0. Between 25 56% anterior obtained...
The stimulatory and inhibitory role of serotonin in gonadotropin secretion the onset puberty male rat has been previously described, but its establishment spermatogenesis is not known. aim this study was to investigate effects serotoninergic inhibition by p-chloroamphetamine (pCA) on prepubertal-to-adult stage reproductive system. Hypothalamic serotonin, gonadotropins sex steroid hormone concentrations were measured, a histopathological analysis seminiferous epithelium carried out animals...