A5015689691- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Cholinesterase and Neurodegenerative Diseases
- Neurological Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Ginkgo biloba and Cashew Applications
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Medicinal Plants and Bioactive Compounds
- Nuclear Receptors and Signaling
- ATP Synthase and ATPases Research
- Medicinal Plants and Neuroprotection
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Curcumin's Biomedical Applications
- Neurological diseases and metabolism
- Mitochondrial Function and Pathology
- Cerebrovascular and genetic disorders
- 14-3-3 protein interactions
- Neurogenetic and Muscular Disorders Research
- Traditional Chinese Medicine Analysis
- Advanced Glycation End Products research
- Pharmacological Effects of Natural Compounds
- Machine Learning in Bioinformatics
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2016-2025
Kanion Pharmaceutical (China)
2024
First Affiliated Hospital of Xi'an Jiaotong University
2023
Beijing University of Chinese Medicine
2006-2020
Kleijnen Systematic Reviews (United Kingdom)
2020
Weatherford College
2020
Hubei University of Chinese Medicine
2006-2010
Community Health Center
2010
University of Manchester
2003-2009
Salford Royal Hospital
2003-2009
Background/Objectives The Trail‐Making Test ( TMT ), which is commonly used to measure executive function, consists of two components ‐A and TMTB ). There a lack normative data for Chinese elderly adults. This study aimed evaluate the validity in screening cognitive impairment. Design 2,294 Chinese‐speaking adults aged 50 85: 1,026 with normal cognition NC 462 mild impairment MCI 108 Alzheimer's disease AD 113 vascular (Va 121 dementia (VaD), 282 uncertain types dementia, 15 mixed dementia....
A hexanucleotide expansion in C9orf72 is the major genetic cause of inherited behavioural variant Frontotemporal dementia (bvFTD) and motor neurone disease (MND), although pathological mechanism(s) underlying remains uncertain.Using antibodies to poly-GA, poly-GP, poly-GR, poly-AP poly-PR proteins, we examined sections cerebral cortex, hippocampus, thalamus, cerebellum spinal cord, from 20 patients with bvFTD and/or MND bearing an for aggregated deposits dipeptide repeat proteins...
Evidence suggests that curcumin, the phytochemical agent in spice turmeric, might be a potential therapy for Alzheimer's disease (AD). Its antioxidant, anti‐inflammatory properties have been investigated extensively. Studies also shown curcumin can reduce amyloid pathology AD. The underlying mechanism, however, is complex and still being explored. In this study, we used APPswe/PS1dE9 double transgenic mice, an AD model, to investigate effects mechanisms of prevention treatment water maze...
Abstract Background The Hopkins Verbal Learning Test (HVLT) has been validated for detecting dementia in English-speaking populations. However, no studies have examined the Chinese version of HVLT scale, and appropriate cut-off scores population remain unclear. Methods 631 subjects aged 60 over were recruited at a memory clinic Dongzhimen Hospital Beijing. Of these, 249 classified as exhibiting normal cognition (NC), 134 diagnosed with mild cognitive impairment (MCI), 97 Alzheimer’s disease...
Pathological relationships between damage to the deep white matter of cerebral cortex [as evidenced by myelin loss (ML)], amyloid angiopathy (CAA) and arteriosclerosis (ART) were investigated in brains 137 patients with autopsy‐confirmed Alzheimer's disease (AD), order better understand causes AD, contribution this pathogenesis disorder. All had some degree CAA one or more brain regions although occipital was severely affected frequently, consequently mean severity score significantly...
Recent studies have shown the therapeutic potential of curcumin in Alzheimer's disease (AD). In 2014, our lab found that reduced Aβ40, Aβ42 and Aβ-derived diffusible ligands mouse hippocampus, improved learning memory. However, mechanisms underlying this biological effect are only partially known. There is considerable evidence brain metabolism indicating AD might be a brain-specific type diabetes with progressive impairment glucose utilisation insulin signalling. We hypothesised target both...
Conventional therapy (CT) such as donepezil and memantine are well-known short-term treatments for the symptoms of Alzheimer's disease (AD). The efficacy them, however, drops below baseline level after 9 months. In China, herbal a complementary is very popular. Should conventional combined with (CT + H) make add-on benefit? this retrospective cohort study, 344 outpatients diagnosed probable dementia due to AD were collected, treatment either CT H or alone in clinical settings. All patients...
Deficits in glucose, impaired insulin signalling and brain resistance are common the pathogenesis of Alzheimer's disease (AD); therefore, some scholars even called AD type 3 diabetes mellitus. Curcumin can reduce amyloid pathology AD. Moreover, it is a well-known fact that curcumin has anti-oxidant anti-inflammatory properties. However, whether or not could regulate signal transduction pathway remains unclear. In this study, we used APPswe/PS1dE9 double transgenic mice as model to...
In China, the aging population and increasing incidence of Alzheimer's disease (AD) other dementias have emerged as major medical concerns. Extensive research new technologies on AD provided possibilities for early intervention, including emerging biomarkers detection drugs with disease-modifying therapy. This report includes a large amount facts figures to describe understanding patients their families about disease, discuss problems they encounter in current environment, outline potential...
Verbal memory impairment, one of the earliest signs Alzheimer's disease (AD), may help identify people with cognitive insufficient for a diagnosis dementia (questionable dementia: QD), at risk developing AD. Other parameters have been found that indicate which QD will go on to develop dementia. Nevertheless, some researchers reported only partial success in differentiating between mild AD and age related impairment.To discover if there are early, pre-clinical markers could patients attending...
Significant losses of synapses have been demonstrated in studies Alzheimer's disease (AD), but structural and functional changes that depend on alterations the postsynaptic density (PSD) area occur prior to synaptic loss play a crucial role pathology AD. Evidence suggests curcumin can ameliorate learning memory deficits To investigate effects synapses, APPswe/PS1dE9 double transgenic mice (an AD model) were used, ultra-structures synapse-associated proteins observed. Six months after...
It has been suggested that patients with motor neurone disease (MND) and those MND combined behavioural variant frontotemporal dementia (bvFTD) (ie FTD + MND) or alone might exist on a continuum based commonalities of neuropathology and/or genetic risk. Moreover, it reported both neuronal glial cell tauopathy can accompany the TDP-43 proteinopathy in cognitive changes, may be fundamental to pathogenesis clinical phenotype. In present study, we sought substantiate these latter findings, test...
Stroke could cause long-term disability, even mortality around the world. Recently, Sodium tanshinone IIA sulfonate (STS), identified from Salvia miltiorrhiza Bunge and was found to have unique efficiency in clinical practice as a potential therapeutic agent for ischemic cerebral infarction. However, systematic investigation about biological mechanism is still lacking. Herein, we utilized high-throughput proteomics approach identify underlying targets treatment of STS stroke.We investigated...