A5034275174- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Pediatric health and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Air Quality and Health Impacts
- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Effects of Radiation Exposure
- Wnt/β-catenin signaling in development and cancer
- Antimicrobial Peptides and Activities
- Dermatology and Skin Diseases
- Advanced biosensing and bioanalysis techniques
- Advanced Aircraft Design and Technologies
- Connective Tissue Growth Factor Research
- Cancer therapeutics and mechanisms
- Advanced Fiber Optic Sensors
- Scientific and Engineering Research Topics
- Hippo pathway signaling and YAP/TAZ
- RNA modifications and cancer
- Energy and Environment Impacts
- Pulmonary Hypertension Research and Treatments
- Occupational and environmental lung diseases
First Affiliated Hospital of Xi'an Jiaotong University
2013-2024
Xi'an Jiaotong University
1989-2016
It is well established that airway remodeling and inflammation are characteristics for chronic obstructive pulmonary disease (COPD). Moreover, cigarette smoke extract (CSE) promots inflammation, apoptosis oxidative stress in COPD. And, there evidence suggested alantolactone (ALT), a sesquiterpene lactone isolated from Inula helenium, plays an adverse role stress. However, few studies have investigated the function mechanism of ALT treatment on COPD pathological process.The levels IL-1 β,...
Pulmonary fibrosis is a progressive and fatal lung disorder with high mortality rate. To date, despite the fact that extensive research trials are ongoing, pulmonary continues to have poor response available medical therapy. Statins, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, known for its broad pharmacological activities, remains remedy against multiple diseases. The present study investigated antifibrotic potential of atorvastatin bleomycin-induced further explore possible...
Chronic obstructive pulmonary disease (COPD) is a progressive, irreversible chronic inflammatory disorder typified by increased recruitment of monocytes, lymphocytes and neutrophils. Because this, as well the convenience peripheral blood nuclear cells (PBMCs) assessments, miRNA profiling PBMCs has drawn increasing attention in recent years for various disease. Therefore, we analyzed mRNA profiles to understand their regulatory network between COPD subjects versus smokers without airflow...
Pulmonary silicosis is characterized by lung fibrosis, which leads to impairment of pulmonary function; the specific mechanism remains be fully elucidated Emodin shows antifibrotic effects in several organs with however, it has not been investigated silicosis. In present study, possible fibrosis and effect emodin silica inhalation‑induced were investigated. particle inhalation was used induce mice. or sirtuin 1 (Sirt1) inhibitor, nicotinamide, treat modeled animals. function assessed using...
Mounting evidence from epidemiological and clinical studies has revealed marked correlations between the air pollutant fine particulate matter (FPM) respiratory diseases. FPM reaches distal airways deposits in alveolar regions where it can act directly on macrophages. However, detailed effect of physiological function macrophages underlying mechanisms remain unclear. In this study, we showed that exposing THP-1-derived to led autophagy dysfunction. activated extracellular signal-regulated...
Introduction Frequent exacerbation phenotype of chronic obstructive pulmonary disease (COPD) represents a more concerning subgroup requiring better prevention and intervention, which airway microbiome provides new perspective for further exploration. Methods To investigate whether frequent exacerbators COPD have distinguishable sputum during clinical stability, patients at high grades with or without were recruited analysis. Sputum samples collected stability underwent 16S rRNA sequencing,...
Epidemiologic studies have demonstrated a direct correlation between fine particulate matter (FPM) exposure and the high risk of respiratory diseases. FPM can penetrate deep into lung deposit in alveoli with breath, where it directly interacts alveolar epithelial cell (APC). However, we know little about effects nor mechanisms on APC. Here, using human APC A549 cells, found that resulted blockade autophagic flux, redox imbalance oxidative stress, mitochondrial fragmentation, increased...
Background Interleukin-17, the major proinflammatory cytokine secreted by Th17 cells, makes essential contribution to pathogenesis of severe asthma, while detailed mechanisms, especially involvement microRNAs which are also important participants in asthma progression, remains largely unclear. Methods In this study, we established a house dust mite (HDM) extract-induced murine asthmatic models and miRNA expression lung tissues mice were profiled microarray assay. The effect miR-365-3p on...
Background . Inflammation plays a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD). We evaluated lncRNA and mRNA expression profile peripheral blood mononuclear cells (PBMCs) from healthy nonsmokers, smokers without airflow limitation, COPD patients. Methods profiling PBMCs 17 14 subjects was detected by high-throughput microarray. The dysregulated lncRNAs validated qPCR. targets mRNAs were predicted GO enrichment analyzed. regulatory ENST00000502883.1 on...
Abstract Background The associations between short- and long-term exposure to ambient fine particulate matter with an aerodynamic diameter ≤ 2.5 µm (PM ) allergic symptoms in middle-aged elderly populations remain unclear, particularly China, where most cities have severe air pollution. Methods Participants (n = 10,142; age 40–75 years) were recruited from ten regions China 2018 2021 for the Predictive Value of Inflammatory Biomarkers Forced Expiratory Volume 1 s (FEV Chronic Obstructive...
Abstract Background: Garsorasib (D-1553), a potent KRAS G12C inhibitor, has previously demonstrated promising anti-tumor activity in G12C-mutated non-small-cell lung cancer (NSCLC) phase 1 study. Here we present the efficacy and safety of garsorasib pivotal 2 Methods: In this open-label, multicenter, single-arm study, patients received 600 mg twice daily 21-day cycles. Eligible criteria included with locally advanced or metastatic NSCLC harboring mutation, who had disease progression after...
Marginal zone B-cell lymphoma of the pulmonary mucosa-associated lymphoid tissue (pulmonary MALT-MZL) is a common type primary lymphoma, but rare as malignant tumor. In present study, 49-year-old male patient was admitted to The First Affiliated Hospital Xi'an JiaTong University (Xi'an, China) with lesion in right upper lung. diagnosed MALT-MZL subsequent undergoing chest computed tomography (CT), routine blood test, pathological and histological examinations, transbronchial lung biopsy...
In this study, we employed bioinformatics techniques to investigate the radiosensitization mechanisms of graphene oxide (GO) and silver-platinum (AgPt) nanocomposites (NCs) on microRNAs (miRNAs) in non-small cell lung cancer (NSCLC). The GO@AgPt were synthesized through a hydrothermal method involving oxide. Characterization structural analysis performed using transmission electron microscopy (TEM), atomic force (AFM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared...
Abstract This paper analyzes the working principle of each component aircraft environmental control system (ECS), takes Boeing 737 as an example, and distribution role temperature sensors in ECS. Then, this presents a guideline for sensor setup suitable subsystem. The accuracy is measured, which verifies that selection set reasonable can ensure good operation
Abstract Based on the Floquet-Liapunov theory, this paper proposes an efficient one-dimensional search approach for stability analysis of pipes conveying pulsatile flow. The instability boundaries a clamped-clamped pipe analyzed in paper. numerical results are satisfactory compared with existing results. Moreover, region which failed to appear ordinary analyses is detected by our computations.
Abstract BACKGROUND The IL-17 superfamily, which mediates cross-talk between the adaptive and innate immune systems, has been associated with severity of asthma. role miRNAs in disease paid much attention. To explore roles asthma relationship miRNAs, we used a model severe driven by chronic respiratory exposure to house dust mite (HDM) wild type IL-17KO mice, followed miRNA profiling assays analysis. METHODS Male female C57BL/6 mice (6-8 weeks old) (C57BL/6 background) were exposed purified...