A5059128928- Chronic Obstructive Pulmonary Disease (COPD) Research
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Pleural and Pulmonary Diseases
- Respiratory viral infections research
- Air Quality Monitoring and Forecasting
- Heme Oxygenase-1 and Carbon Monoxide
- Lung Cancer Diagnosis and Treatment
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Pediatric health and respiratory diseases
- Circular RNAs in diseases
- Respiratory and Cough-Related Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- SARS-CoV-2 and COVID-19 Research
- Energy and Environment Impacts
- IgG4-Related and Inflammatory Diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Congenital Anomalies and Fetal Surgery
- Asthma and respiratory diseases
- Salivary Gland Disorders and Functions
- Sarcoidosis and Beryllium Toxicity Research
Peking University First Hospital
2016-2025
Peking University
2016-2025
Tibet Autonomous Region People's Hospital
2025
AbstractEpidemiologic studies have reported the association between fine particles (aerodynamic diameter ≤ 2.5 μm; PM2.5) and health effects, but immunological mechanisms are not clear. To investigate dose time-dependent role of toll-like receptor (TLR) Th1/Th2 shift in local systemic inflammation induced by PM2.5, mice were subjected to intratracheal instillation 2.5, 5, or 10 mg/kg PM2.5 this study. After 24 h, 72 7 days, 14 sacrificed measure TLR2 TLR4 expressions related cytokines...
Background: Fine particulate matter (PM2.5) exposure is proved to be associated with illnesses, but the mechanism not clear. Potential effects of PM2.5 on innate immunity have become a hotspot recently. Confronting PM2.5, macrophages are able activated and induce inflammatory responses. Whether affects macrophage polarization mechanisms remains further explored. Afterwards, whether Sirtuin1 (SIRT1) an important intermediate regulator in various physiological processes takes part induced by...
Background Intelligent wearable devices have potential for chronic obstructive pulmonary disease (COPD) monitoring, but the effectiveness of combining cough and blowing sounds assessment is unclear. Objective The objective was to assess COPD severity via physiological parameters audio data collected by a smartwatch. Methods patients underwent lung function tests, electrocardiograms, blood gas analysis, 6-min walk tests. patients’ peripheral arterial oxygen saturation (SpO 2 ), heart rate...
Objectives Morning dry mouth, commonly seen in Obstructive Sleep Apnea (OSA) patients, is absent current OSA screening tools. This study evaluated the link between morning mouth and OSA's clinical symptoms complications, aiming to determine its viability as a indicator.
Numerous epidemiological studies have demonstrated that chronic PM2.5 exposure was associated with the lung carcinogenesis without known potential mechanisms. Exosomes-derived non-coding RNAs, including miRNAs, are proposed to play critical role in occurrence and development of malignant diseases. So identification exosomes-derived miRNAs could help us better understand molecular toxicity PM2.5-induced cancer. Establishment animal cell model conducted as before. HE staining used for...
Nitrous oxide (N2O) has gained increasing popularity as a recreational drug, causing hallucinations, excitation, and psychological dependence. However, side effects have been reported in recent years. Our case report proposes correlation among N2O, pulmonary embolism (PE), deep vein thrombosis (DVT) emphasizes the role of homocysteine (Hcy) thrombotic events.A 29-year-old man with long-term N2O abuse sought evaluation after acute chest pain. A diagnostic workup revealed PE, DVT,...
Background: SARS-CoV-2 tends to cause more severe disease in patients with COPD once they are infected. We aimed investigate the rates of influenza, pneumococcal and COVID-19 vaccination uptake determine whether pandemic widespread against had any impact on intention accept influenza vaccines these patients. Methods: conducted a multi-center cross-sectional survey seven tertiary hospitals Beijing consecutively recruited outpatients from June 1st July 30th, 2021. The included patient's...
Fibrosing mediastinitis (FM) is a rare disease. FM thought to be related prior granulomatous mediastinal infection, such as histoplasmosis or tuberculosis. The majority of cases have been reported in endemic regions for histoplasmosis. characteristics China, where the prevalence tuberculosis high, not reported. We analyzed clinical, imaging, and bronchoscopic features Chinese patients with promote awareness this disease.Between January 2005 June 2015, twenty were diagnosed our hospital....
PM2.5 was closely linked to lung cancer worldwide.However, the mechanism involved in induced is still largely unknown.In this study, we performed chronic stimulation animal and cells model investigate carcinogenetic mechanisms of by targeting EMT through Notch1 signal pathway.Next, focused on miRNA pathway activation.We found could induce event vivo vitro, while reducing miR-139-5p expression activating meanwhile.And blocking specific small molecule inhibitor reverse EMT.Then, overexpression...
Abstract Background The associations between short- and long-term exposure to ambient fine particulate matter with an aerodynamic diameter ≤ 2.5 µm (PM ) allergic symptoms in middle-aged elderly populations remain unclear, particularly China, where most cities have severe air pollution. Methods Participants (n = 10,142; age 40–75 years) were recruited from ten regions China 2018 2021 for the Predictive Value of Inflammatory Biomarkers Forced Expiratory Volume 1 s (FEV Chronic Obstructive...
China has a huge population with respiratory diseases, these diseases should be managed well in primary care, however, care physicians' knowledge level of were unknown. The aim the study was to assess asthma, CAP, COPD, and influenza China. An e-questionnaire distributed attendees academic conferences from July, 2017 December, 2018. 7391 questionnaires returned 4815 valid analyzed, 3802 (79.0%) community health service centers 1013 (21.0%) township hospitals. average score questionnaire 83.3...
With pandemic of coronavirus disease 2019 (COVID-19), human coronaviruses (HCoVs) have recently attached worldwide attention as essential pathogens in respiratory infection. HCoV-229E has been described a rare cause lower infection immunocompetent adults.We reported 72-year-old man infected by with rapid progression to acute distress syndrome, conjunction new onset atrial fibrillation, intensive care unit acquired weakness, and recurrent hospital pneumonia. Clinical radiological data were...
This study investigated the association between obstructive sleep apnea (OSA) and preserved ratio impaired spirometry (PRISm) in a community population.Baseline data from prospective cohort study, Predictive Value of Combining Inflammatory Biomarkers Rapid Decline FEV1 for COPD (PIFCOPD), were used cross-sectional analysis. Participants aged 40-75 years recruited their demographic information medical history collected. The STOP-Bang questionnaire (SBQ) was to assess risk OSA. Pulmonary...
Pigeon paramyxovirus 1 (PPMV-1) is an antigenic host variant of avian 1. Sporadic outbreaks PPMV-1 infection have occurred in pigeons China; however, few cases human been reported. The purpose this article to report a case severe individual with probable post-COVID-19 syndrome (long COVID) who presented rapidly progressing pulmonary infection. patient was 66-year-old man admitted the intensive care unit 11 days after onset pneumonia and recovered 64 onset. isolated from patient's sputum...
In China, the high prevalence and mortality rate of Chronic Obstructive Pulmonary Disease (COPD) poor intervention effect makes it into a heavy social burden. The main reason is that current diagnosis COPD mainly based on static lung function, which difficult for early intervention. Through matching predictive model high-risk groups rewards FEV1 rapid decline as core, we will establish warning prove its validity socio-economic value.This multi-center, prospective, cohort study. A total...
Chronic obstructive pulmonary disease (COPD) has become a major public-health problem in China. Surfactant protein D (SP-D) is very promising biomarker and therapeutic target for COPD. To assess whether baseline serum SP-D associated with lung function decline incident COPD.This longitudinal study was initiated 2009 community Beijing. Data were collected on spirometry, the level of measured 772 non-COPD subjects aged 40-70 years old. In 2012, spirometry repeated 364 individuals, 37 whom had...
We report a rare case of adenoviral pneumonia in previously healthy pregnant woman at 26(+4) weeks' gestation. She presented with persistent high fever, cough for 5 days, and developed progressive dyspnea hypoxemic respiratory failure bilateral pulmonary infiltrates pleural effusions. Aggressive supportive care timely obstetrical management saved the mother prevented preterm delivery fetal anomaly.