A5100713387- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- PARP inhibition in cancer therapy
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Global Cancer Incidence and Screening
- Patient-Provider Communication in Healthcare
- Telomeres, Telomerase, and Senescence
- Epigenetics and DNA Methylation
- PI3K/AKT/mTOR signaling in cancer
- Sexual function and dysfunction studies
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Esophageal Cancer Research and Treatment
- RNA Interference and Gene Delivery
- Asthma and respiratory diseases
First Affiliated Hospital of Xi'an Jiaotong University
2016-2025
Guangdong Province Women and Children Hospital
2024
Hefei University of Technology
2024
Dongguan People’s Hospital
2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Xi'an Jiaotong University
2013-2023
Shaanxi Provincial People's Hospital
2016-2023
Shanxi Medical University
2016-2023
Qingdao Agricultural University
2022-2023
Long-term exposure to ambient and household particulate matter (PM2.5) causes death health loss, both are the leading risk factor global disease burden. We assessed spatiotemporal trends of PM2.5 attributable burdens across various diseases at global, regional, national levels from 1990 2017.Data on PM2.5-attributable were extracted Global Burden Disease (GBD) study 2017. Numbers age-standardized rates (ASRs) deaths, disability-adjusted life years (DALYs) corresponding estimated annual...
It is well established that airway remodeling and inflammation are characteristics for chronic obstructive pulmonary disease (COPD). Moreover, cigarette smoke extract (CSE) promots inflammation, apoptosis oxidative stress in COPD. And, there evidence suggested alantolactone (ALT), a sesquiterpene lactone isolated from Inula helenium, plays an adverse role stress. However, few studies have investigated the function mechanism of ALT treatment on COPD pathological process.The levels IL-1 β,...
Several observational studies have found that idiopathic pulmonary fibrosis (IPF) is often accompanied by elevated circulating C-reactive protein (CRP) levels. However, the causal relationship between them remains to be determined. Therefore, our study aimed explore effect of CRP levels on IPF risk two-sample Mendelian randomization (MR) analysis.We analyzed data from two genome-wide association (GWAS) European ancestry, including (204,402 individuals) and (1028 cases 196,986 controls). We...
This study aimed to evaluate the potential association between body roundness index (BRI) and kidney stone prevalence in adults United States.
This study was aimed to explore if lncRNA MALAT1 would modify chemo-resistance of non-small cell lung cancer (NSCLC) cells by regulating miR-197-3p and p120 catenin (p120-ctn). Within this investigation, we totally recruited 326 patients, purchased 4 NSCLC lines A549, H1299, SPC-A-1 H460. Moreover, cisplatin, adriamycin, gefitinib paclitaxel were arranged as chemotherapies, half maximal inhibitory concentration (IC50) values calculated evaluate the cells. Furthermore, mice models also...
Lung cancer is the most common malignancy worldwide. Thus, there a critical need for diagnostic biomarkers with adequate sensitivity and specificity lung detection. Glycans in glycoproteins are significantly altered cancer, may serve as tool identifying potential biomarkers. Recent studies have reported changes α-1-antitrypsin (A1AT) glycosylation serum, tissue cell lines. In this study, lectin microarray was used to detect serum A1AT from patients adenocarcinoma (ADC), squamous small-cell...
Abstract Background Community-acquired pneumonia (CAP) is a major public health challenge worldwide. However, the aetiological and disease severity-related pathogens associated with CAP in adults China are not well established based on detection of both viral bacterial agents. Methods A multicentre, prospective study was conducted involving 10 hospitals located nine geographical regions from 2014 to 2019. Sputum or bronchoalveolar lavage fluid (BALF) samples were collected each recruited...
Abstract Background The novel Akt inhibitor, API-1, induces apoptosis through undefined mechanisms. current study focuses on revealing the mechanisms by which API-1 apoptosis. Results rapidly and potently reduced levels of Mcl-1 primarily in API-1-senstive lung cancer cell lines. Ectopic expression protected cells from induction API-1. treatment decreased half-life Mcl-1, whereas inhibition proteasome with MG132 rescued reduction induced accompanied a rapid increase phosphorylation...
The majority of lung cancer(LC) patients are diagnosed at advanced stage with a poor prognosis. However, there is still no ideal diagnostic and prognostic prediction model for cancer.Data CEA, CYFRA21-1 NSE test LC benign diseases (BLDs) or healthy people from Physical Examination Center was collected. Samples were divided into three data sets as needed. Reassign kinds tumor markers (TMs) according to their distribution characteristics in different populations. Diagnostic models thus...
BRAFV600E, the most common genetic alteration, has become a major therapeutic target in thyroid cancer. Vemurafenib (PLX4032), specific inhibitor of BRAFV600E kinase, exhibits antitumor activity patients with BRAFV600E-mutated However, clinical benefit PLX4032 is often limited by short-term response and acquired resistance via heterogeneous feedback mechanisms. Disulfiram (DSF), an alcohol-aversion drug, shows potent efficacy copper (Cu)-dependent way. its cancer effect on cellular to BRAF...
Abstract Background Phase III trials evaluating the efficacy of gefitinib (IRESSA) in non-small cell lung cancer (NSCLC) lend support to need for improved patient selection terms use. Mutation epidermal growth factor receptor ( EGFR ) gene is reported be associated with clinical responsiveness gefitinib. However, gefitinib-sensitive and prolonged stable-disease-defined tumors without mutation have also been reported. Methods To identify other key factors involved sensitivity, we analyzed...
The current study aims to investigate the fuctional role of miRNA-25 in non-small cell lung cancer (NSCLC) cells. Quantitative real-time polymerase chain reaction (qRT-PCR) was used detect expression miR-25 NSCLC lines and 11 pairs human non-cancerous tissues. inhibitor stably transfected into line A549 Then effects downregulating on proliferation, cycle arrest, chemosensitivity cisplatin, growth vivo xenograft were investigated. Direct regulation its target gene, division 42 (CDC42),...
Family of forkhead box transcription factors, including P4 (FOXP4), plays an important role in oncogenesis. The current study is to evaluate the FOXP4 regulating human non-small cell lung cancer (NSCLC). Quantitative RT-PCR and Western blot were performed gene protein expressions six NSCLC lines 55 patients. Lentivirus small hairpin RNA (FOXP4-shRNA) was used downregulate A549 H1703 cells. Its effect on growth, invasion, cycle evaluated by proliferation assay, migration respectively. Dual...
Pulmonary silicosis is characterized by lung fibrosis, which leads to impairment of pulmonary function; the specific mechanism remains be fully elucidated Emodin shows antifibrotic effects in several organs with however, it has not been investigated silicosis. In present study, possible fibrosis and effect emodin silica inhalation‑induced were investigated. particle inhalation was used induce mice. or sirtuin 1 (Sirt1) inhibitor, nicotinamide, treat modeled animals. function assessed using...
8502 Background: Median Overall survival (mOS) of stage IIIA resected NSCLC was 59.4 months (m) in CTONG 1104 adj gefitinib and 26.2m SAKK neoadjuvant chemo trial. EMERGING-CTONG1103 showed neo-adjuvant/adjuvant erlotinib treatment significantly improved progression-free (PFS) vs standard doublet chemotherapy patients (pts) with epidermal growth factor receptor ( EGFR) mutation-positive resectable (N2) non-small-cell lung cancer (NSCLC). Here, we present the final overall (OS) results from...
Abstract Background Community-acquired pneumonia (CAP) is a common and serious condition that can be caused by variety of pathogens. However, much remains unknown about how these pathogens interact with the lower respiratory commensals, whether any correlation exists between dysbiosis microbiota disease severity prognosis. Methods We conducted retrospective cohort study to investigate composition dynamics sputum in patients diagnosed CAP. In total, 917 specimens were collected consecutively...
Sarcopenia has been reported to be a prognostic factor for chronic obstructive pulmonary disease (COPD). However, the relationship between ratio of blood urea nitrogen creatinine (BUN/Cr) and sarcopenia in patients with COPD remain unclear. Therefore, purpose this study is explore whether can used as predictor hospitalized patients.The skeletal muscle area index (SMI) at level 12th thoracic vertebra (T12) was assess risk patients. This single center cross-sectional conducted by analyzing...
Purpose: To evaluate the accuracy of inflammatory biomarkers in differentiating patients with asthma–COPD overlap (ACO) from those COPD alone. Methods: Clinical data 134 and 48 ACO admitted to First Affiliated Hospital Xi'an Jiaotong University January 2016 June 2019 were retrospectively analyzed. Receiver operating characteristic (ROC) curve analysis was performed determine best cut-off values fractional exhaled nitric oxide (FeNO), blood eosinophil counts (EOS), neutrophil lymphocyte ratio...
Abstract The study aims to investigate the distress level and its influencing factors in Chinese pulmonary nodules patients. A total of 163 outpatients a tertiary hospital Xi'an, China, were recruited investigated by using Impact Event Scale, Decision Conflict Consultation Care Measure, Lung Cancer Worry Scale demographic questionnaire. logistic regression model was used identify distress. mean IES score 37.35 ± 16.65, which moderate level. Patients aged 50–60 years, with higher decision...