A5101849986- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
- Cardiac Imaging and Diagnostics
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Acute Ischemic Stroke Management
- Long-Term Effects of COVID-19
- Olfactory and Sensory Function Studies
- Hemodynamic Monitoring and Therapy
- Ophthalmology and Eye Disorders
- Cerebrovascular and Carotid Artery Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Nasal Surgery and Airway Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac electrophysiology and arrhythmias
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Obstructive Sleep Apnea Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Electrical and Bioimpedance Tomography
- Neurosurgical Procedures and Complications
- RNA modifications and cancer
Qilu Hospital of Shandong University
2016-2025
Air Force Medical University
2010-2025
Xijing Hospital
2010-2025
Zhejiang Chinese Medical University
2025
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2025
Shanghai Jiao Tong University
2023-2024
XinHua Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Shanghai Institute of Hematology
2024
Shandong University
2019-2024
Abstract On the basis of Covid-19-induced pulmonary pathological and vascular changes, we hypothesize that anti-vascular endothelial growth factor (VEGF) drug bevacizumab might be beneficial for treating Covid-19 patients. From Feb 15 to April 5, 2020, conducted a single-arm trial (NCT04275414) recruited 26 patients from 2-centers (China Italy) with severe Covid-19, respiratory rate ≥30 times/min, oxygen saturation ≤93% ambient air, or partial arterial pressure fraction inspiration O 2 ratio...
BACKGROUND: The frequency and prognostic significance of subacute neurological improvement (SNI) on 90-day outcomes after acute intracerebral hemorrhage are unknown. METHODS: Secondary analyses participant data from the INTERACT2 trial (second Intensive Blood Pressure Reduction in Acute Intracerebral Hemorrhage Trial). SNI included any, moderate, significant, substantial defined as ≥1, ≥2, ≥3, ≥4 points decrease, respectively, National Institutes Health Stroke Scale 24 hours to 7 days...
<h3>Objective:</h3> To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). <h3>Methods:</h3> Associations ICH sites poor (death [6] or major disability [3–5] modified Rankin Scale) European Quality Life Scale (EQ-5D) utility scores at 90 days were assessed logistic regression models. <h3>Results:</h3> Of 2,066 patients included...
Abstract Risk prediction for subsequent cardiovascular events remains an unmet clinical issue in patients with coronary artery disease. We aimed to investigate prognostic metabolic biomarkers by considering both shared and distinct disturbance associated the composite individual events. Here, we conducted untargeted metabolomics analysis 333 incident matched controls. The were designated as death, myocardial infarction/stroke heart failure. A total of 23 differential metabolites majority...
BACKGROUND: Vascular calcification, which is characterized by calcium deposition in arterial walls and the osteochondrogenic differentiation of vascular smooth muscle cells, an actively regulated process that involves complex mechanisms. calcification associated with increased cardiovascular adverse events. The role 4-hydroxynonenal (4-HNE), most abundant stable product lipid peroxidation, has been poorly investigated. METHODS: Serum was collected from patients chronic kidney disease...
Abstract Background Community-acquired pneumonia (CAP) is a major public health challenge worldwide. However, the aetiological and disease severity-related pathogens associated with CAP in adults China are not well established based on detection of both viral bacterial agents. Methods A multicentre, prospective study was conducted involving 10 hospitals located nine geographical regions from 2014 to 2019. Sputum or bronchoalveolar lavage fluid (BALF) samples were collected each recruited...
<title>Abstract</title> Background The aim of our study was to describe the characteristics oral microbiome in patients with chronic obstructive pulmonary disease (COPD) different function grades, and investigate impact smoking inhaled corticosteroids (ICS) on various lung impairments. Methods Pyrosequencing polymerase chain reaction-amplified 16s rDNA genes used microbiome. COPD diagnosed based Global Initiative for Chronic Obstructive Lung Disease (GOLD) Guidelines 2021. Results Bacterial...
The relation between metabolic and functional derangement in various cardiomyopathies has not been well characterized. This information was specifically sought a spontaneous cardiomyopathic model. Metabolic hemodynamic parameters were obtained glucose-perfused beating hearts of 180-200-day-old Syrian hamsters age-matched healthy animals. period the hamster lifetime is intermediary necrotic phase appearance heart failure. We used 31P nuclear magnetic resonance spectroscopy to analyze energy...
Purpose: To investigate the CT features of drug-resistant pulmonary tuberculosis (DR-PTB) and diagnostic value in DR-PTB diagnosis to provide imaging evidence for timely detection Mycobacterium . Materials Methods: A total 1546 cases (PTB) with complete clinical data, chest images defined drug sensitivity testing results were consecutively enrolled; 516 included group, 1030 drug-sensitive (DS-PTB) drug-sensitivity group. Comparative analyses symptoms findings conducted. Univariate logistic...
Abstract Background Little is known about whether the influence of glycemic variability on arrhythmia related to age in type 2 diabetes mellitus (T2DM). Therefore, we aimed compare association between and middle-aged elderly T2DM patients. Methods A total 107 patients were divided into two groups: group (EDM, n = 73) (MDM, 34). The main clinical data, continuous glucose monitoring (CGM) dynamic ECG reports collected. parameters including standard deviation blood (SDBG), largest amplitude...
Pulmonary rehabilitation (PR) is a widely recognized nonpharmacologic therapy for chronic obstructive pulmonary disease (COPD), but most of the current studies on whether PR can benefit COPD patients are based evaluation symptoms and function, which limited to certain extent. Because characterized by potential regional lung changes in morphology pathophysiology, this study was designed evaluate effects individualized function with stable COPD.In study, who met criteria were included, they...
Abstract Atherosclerosis, characterized by the accumulation of lipid plaques on inner walls arteries, is leading cause heart attack, stroke and severe ischemic injuries. Senescent cells have been found to accumulate within atherosclerotic lesions contribute progression atherosclerosis. In our previous study, we discovered that suppressing Larp7 accelerates senescence inhibiting Sirt1 activity, resulting in increased atherosclerosis high‐fat diet (HFD) fed ApoE deficient ( KO ) mice. However,...
Risk models integrating new biomarkers to predict cardiovascular events in acute coronary syndromes (ACS) are lacking. Therefore, we evaluated the prognostic value of addition clinical predictors and developed a biomarker-based risk model for major adverse (MACE) within 12 months after hospital admission with ACS.Patients (n = 4407) consecutively enrolled from November, 2017 October, 2019 three hospitals prospective Chinese registry (BIomarker-based Prognostic Assessment Patients Stable...
Homologous recombination deficiency (HRD) is a well-known biomarker which could predict poly-ADP ribose polymerase 1 (PARP) inhibitor and platinum drug response. As an aggressive cancer, small-cell lung cancer (SCLC) sensitive to drugs, but relapse occurs rapidly. Herein, we aim illustrate the genomic alteration patterns of homologous repair (HRR)-related genes in Chinese SCLC cohort further analyze relationship among HRR gene mutations known biomarkers immune checkpoint (ICI) response,...
Abstract Shortening the duration of viral shedding severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is critical to controlling transmission, alleviating burden on healthcare system, and ultimately mitigating impact pandemic. This randomized, single‐blind, placebo‐controlled clinical trial aimed investigate safety efficacy gargling with plasma‐activated water (PAW) prolonged in patients infected SARS‐CoV‐2 Delta Omicron variants. Sixty‐two subjects, aged 18–80 years SARS‐CoV‐2,...
Abstract Light plays a direct crucial role in the switch between sleep and arousal regulation of physiology behaviour, such as circadian rhythms emotional change. Artificial lights, which are different from natural light sources with continuous spectrum, composed three single-colour lights increasingly applied modern society. However, vivo research on mechanisms blue light-regulated is still insufficient. In this work, we detected effects inserting white or for 1 h during dark period...
Abstract Chest electrical impedance tomography (EIT) is a promising application which used to monitor the ventilation and perfusion of lung at bedside dynamically. The aim study was introduce first Chinese made chest EIT device for ICU (Pulmo EIT-100). system design hardware software briefly introduced. performance compared PulmoVista 500 (Dräger Medical) in healthy volunteers. Pulmo EIT-100 consists measurement module, power supply PC all-in-one machine, medical cart accessories. current...
The olfaction is related to flow in the olfactory cleft. However, There a lack of studies on relationship between characteristics cleft and function. In this study, anatomical structure was reconstructed three dimensions using raw data obtained from CT scans sinuses 32 enrolled volunteers. Sniffin' Sticks test used examine olfaction. We investigated correlation airflow parameters function healthy adults by computational fluid dynamics method. found that parameters, airflow, velocity, ratio,...
Abstract Background Triage decisions for chest pain patients receiving usual care are based on a dynamic and comprehensive strategy performed in the physician's mind. It remains controversial whether simple, structured risk tools can surpass real, complex judgments. Hypothesis The potentially used History, Electrocardiogram, Age, Risk factors, Troponin (HEART) score would help identify low‐risk discharge. Methods Patients with acute, non‐traumatic managed according to were consecutively...