A5102912546- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- PARP inhibition in cancer therapy
- Autophagy in Disease and Therapy
- Antiplatelet Therapy and Cardiovascular Diseases
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Ethics in Clinical Research
- Cardiac Ischemia and Reperfusion
- Alcohol Consumption and Health Effects
- Cardiovascular Function and Risk Factors
- Sirtuins and Resveratrol in Medicine
- Diabetes Treatment and Management
- Clinical practice guidelines implementation
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- SARS-CoV-2 and COVID-19 Research
- Dermatological and Skeletal Disorders
- Atherosclerosis and Cardiovascular Diseases
- Cannabis and Cannabinoid Research
- Biomedical Ethics and Regulation
- Microbial metabolism and enzyme function
Qilu Hospital of Shandong University
2012-2024
National Medical Products Administration
2024
Shandong University
2011-2021
Abstract On the basis of Covid-19-induced pulmonary pathological and vascular changes, we hypothesize that anti-vascular endothelial growth factor (VEGF) drug bevacizumab might be beneficial for treating Covid-19 patients. From Feb 15 to April 5, 2020, conducted a single-arm trial (NCT04275414) recruited 26 patients from 2-centers (China Italy) with severe Covid-19, respiratory rate ≥30 times/min, oxygen saturation ≤93% ambient air, or partial arterial pressure fraction inspiration O 2 ratio...
BACKGROUND: Vascular calcification, which is characterized by calcium deposition in arterial walls and the osteochondrogenic differentiation of vascular smooth muscle cells, an actively regulated process that involves complex mechanisms. calcification associated with increased cardiovascular adverse events. The role 4-hydroxynonenal (4-HNE), most abundant stable product lipid peroxidation, has been poorly investigated. METHODS: Serum was collected from patients chronic kidney disease...
Hypoxia-induced pulmonary hypertension (HPH) increases lipid peroxidation with generation of toxic aldehydes that are metabolized by detoxifying enzymes, including ALDH2 (aldehyde dehydrogenase 2). However, the role and in HPH pathogenesis remain undefined. Approach Results: To determine HPH, C57BL/6 mice, transgenic knockout (ALDH2-/-) mice were exposed to chronic hypoxia, recombinant tissue-specific overexpression adeno-associated viruses introduced into arteries via tail vein injection...
Myocardial ischaemia/reperfusion (I/R) injury attenuates the beneficial effects of reperfusion therapy. Poly(ADP-ribose) polymerase (PARP) is overactivated during myocardial I/R injury. Mitophagy plays a critical role in development However, effect PARP activation on mitophagy cardiomyocytes unknown. In this study, we found that induced and mouse hearts. inhibition reduced infarct size suppressed after vitro, hypoxia/reoxygenation (H/R) activated PARP, promoted cell apoptosis cardiomyocytes....
Background: Inflammatory disorder and acinar cell death contribute to the initiation progression of severe acute pancreatitis (SAP). Adenosine kinase (ADK) has potential effects on both inflammation death. However, role ADK in SAP remains be explored. Methods: To establish an experimental model, male C57BL/6 mice were intraperitoneally injected with cerulein (50 μg/kg, seven doses at hourly intervals) LPS (10 mg/kg, last injection). For inhibition, ABT702 (1.5 mg/kg) was 1 h before...
Increased adenosine helps limit infarct size in ischaemia/reperfusion-injured hearts. In cardiomyocytes, 90% of is catalysed by kinase (ADK) and ADK inhibition leads to higher concentrations both intracellular extracellular adenosine. However, the role myocardial ischaemia/reperfusion (I/R) injury remains less obvious. We explored I/R using mouse left anterior ligation model. To inhibit ADK, inhibitor ABT-702 was intraperitoneally injected or AAV9 (adeno-associated virus)-ADK-shRNA...
Abstract Acute liver injury (ALI) is a common life-threatening condition with high mortality rate due to disease-related death. However, current therapeutic interventions for ALI remain ineffective, and the development of effective novel therapies urgently needed. Liver samples from patients drug-induced were collected detect adenosine kinase (ADK) expression. Male C57BL/6 J mice, hepatocyte-specific ADK knockout ( HKO ) their controls f/f exposed acetaminophen (APAP) other treatments...
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are now recommended for patients with heart failure, but the mechanisms that underlie protective role of SGLT2i in cardiac remodeling remain unclear. Aldehyde dehydrogenase 2 (ALDH2) effectively prevents remodeling. Here, key ALDH2 efficacy on was studied.
ABSTRACT On the basis of Covid-19-induced pulmonary pathological and vascular changes, we hypothesized that anti-VEGF drug bevacizumab might be beneficial for treating Covid-19 patients. We recruited 26 patients from 2-centers (China Italy) with confirmed severe Covid-19, respiratory rate ≥ 30 times/min, oxygen saturation ≤ 93% ambient air, or partial arterial pressure to fraction inspiration O 2 ratio (PaO /FiO ) >100mmHg 300 mmHg, diffuse pneumonia by chest radiological imaging. This...
Although subject recruitment for clinical trials in Shandong has been carried out with an awareness of international regulatory and ethical frameworks, there have some defects the process. The objective this study is to analyze current status Shandong. We conducted a survey among 198 principal investigators (PIs) 543 subjects. results were summarized calculated as percentage according responses each question by PIs This indicated that ethics committee should strengthen review enhance...
A 41-year-old woman with chest pain for 6 hours was admitted to our center, presenting acute myocardial infarction. Coronary angiography showed total occlusion in the proximal left anterior descending artery due late stent thrombosis. After thrombus aspiration and intracoronary administration of 0.5 mg tirofiban, repeated that no obvious residual stenosis remained. The patient underwent drug-coated balloon angioplasty 69 days ago then administered dual antiplatelet treatment (aspirin...
Background: Stent placement remains a challenge for coronary bifurcation lesions. While both simple and complex stenting strategies are available, it is unclear which one results in better clinical outcomes. This meta-analysis aims to explore the long-term prognosis following treatment with 2 strategies. Method: Randomized controlled trials found from searches of PubMed, EMBASE, Cochrane Central Register Controlled Trials were included this meta-analysis. The stent strategy was identified as...
Although an invasive strategy has been recommended within 24 h for patients with non-ST-segment elevation myocardial infarction (NSTEMI), the optimal timing of remains controversial. We sought to investigate association between different timings strategies and clinical outcomes in NSTEMI.Patients admitted NSTEMI from Evaluation Management Patients Acute ChesT pain China (EMPACT) registry January 2016 September 2017 were included. The primary major adverse cardiac events (MACEs) 30 days....
Acute myocardial infarction (AMI) causes a series of pathophysiological changes, including necrosis, edema, and microvascular damage. These changes eventually lead to severe cardiovascular events, such as ventricular remodeling, heart failure, papillary dysfunction. Impaired cardiac function after ST-segment elevation (STEMI) often manifests decrease in left ejection fraction (LVEF). Clinical trials have shown that angiotensin receptor-neprilysin inhibitor (ARNI) treatment has the potential...
The performance of CRA directly affects the quality clinical trials. In appraisal performance, satisfaction institutions plays a vital role. This article presents outcome survey on 16 research centers in Shandong province, and analysis 503 samples regarding their exploratory factor confirmatory respectively. purpose is to identify main factors for build model evaluate hospitals CRA. Key words: Clinical trails; CRA; Satisfaction