A5100417459- Acute Myocardial Infarction Research
- Alcohol Consumption and Health Effects
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Ischemia and Reperfusion
- RNA Interference and Gene Delivery
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiac Arrest and Resuscitation
- Eicosanoids and Hypertension Pharmacology
- Autophagy in Disease and Therapy
- Cardiac Fibrosis and Remodeling
- Cancer therapeutics and mechanisms
- Extracellular vesicles in disease
- Ginseng Biological Effects and Applications
- Coronary Interventions and Diagnostics
- Insect symbiosis and bacterial influences
- Advanced biosensing and bioanalysis techniques
- Insect Resistance and Genetics
- Photodynamic Therapy Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- GDF15 and Related Biomarkers
- Acute Kidney Injury Research
- Emergency and Acute Care Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Tianjin University of Traditional Chinese Medicine
2025
Hebei North University
2025
Qilu Hospital of Shandong University
2015-2024
Nanchang University
2023
South China Agricultural University
2021-2023
First People's Hospital of Kunshan
2023
Second Affiliated Hospital of Shantou University Medical College
2022-2023
Shantou University
2022-2023
Southwest Jiaotong University
2023
Abstract Despite the development of advanced technologies for interventional coronary reperfusion after myocardial infarction, a substantial number patients experience high mortality due to ischemia‐reperfusion (MI/R) injury. An in‐depth understanding mechanisms underlying MI/R injury can provide crucial strategies mitigating damage and improving patient survival. Here, it is discovered that 4‐hydroxy‐2‐nonenal (4‐HNE) accumulates during MI/R, accompanied by rates ferroptosis. The...
Polymeric vectors have shown great promise in the development of safe and efficient gene delivery systems; however, only a few been developed clinical settings due to poor transport across multiple physiological barriers. To address this issue promote translocation polymeric vectors, new type vector, bioreducible fluorinated peptide dendrimers (BFPDs), was designed synthesized by reversible cross-linking low generation dendrimers. Through masterly integration all features cross-linking,...
Mitophagy, a selective form of autophagy, is excessively activated in myocardial ischemia/reperfusion (I/R). The study investigated whether aldehyde dehydrogenase 2 (ALDH2) exerted its cardioprotective effect by regulating mitophagy. Myocardial infarct size and apoptosis after I/R rats were ameliorated Alda-1, an ALDH2 activator, aggravated inhibition. Both hypoxia/reoxygenation H9C2 cells, activation suppressed phosphatase tensin homolog-induced putative kinase 1 (PINK1)/Parkin expression,...
Stubborn biofilm infections pose serious threats to human health due the persistence, recurrence, and dramatically magnified antibiotic resistance. Photodynamic therapy has emerged as a promising approach combat biofilm. Nevertheless, how inhibit bacterial signal transduction system efflux pump conquer recurrence resistance remains challenging unaddressed issue. Herein, boric acid-functionalized lipophilic cationic type I photosensitizer, ACR-DMP, is developed, which efficiently generates...
Abstract Risk prediction for subsequent cardiovascular events remains an unmet clinical issue in patients with coronary artery disease. We aimed to investigate prognostic metabolic biomarkers by considering both shared and distinct disturbance associated the composite individual events. Here, we conducted untargeted metabolomics analysis 333 incident matched controls. The were designated as death, myocardial infarction/stroke heart failure. A total of 23 differential metabolites majority...
BACKGROUND: Vascular calcification, which is characterized by calcium deposition in arterial walls and the osteochondrogenic differentiation of vascular smooth muscle cells, an actively regulated process that involves complex mechanisms. calcification associated with increased cardiovascular adverse events. The role 4-hydroxynonenal (4-HNE), most abundant stable product lipid peroxidation, has been poorly investigated. METHODS: Serum was collected from patients chronic kidney disease...
The mitochondrial enzyme aldehyde dehydrogenase 2 (ALDH2) catalyzes the detoxification of acetaldehyde and endogenous lipid aldehydes. Approximately 40% East Asians, accounting for 8% human population, carry E504K mutation in ALDH2 that leads to accumulation toxic reactive aldehydes increases risk cardiovascular disease, cancer, Alzheimer among others. However, role acute kidney injury (AKI) remains poorly defined is therefore subject present study using various cellular organismal sources....
Clinical studies show that the most common single-point mutation in humans, ALDH2 (aldehyde dehydrogenase 2) rs671 mutation, is a risk factor for development and poor prognosis of atherosclerotic cardiovascular diseases, but underlying mechanism remains unclear. Apoptotic cells are phagocytosed eliminated by macrophage efferocytosis during atherosclerosis, enhancement arterial reduces atherosclerosis development. Plaque areas, necrotic core size, apoptosis, aortic lesions were investigated...
Moderate alcohol consumption has beneficial effects on endothelial nitric‐oxide synthase (eNOS) activation, which can engender an array of anti‐atherogenic actions. Here we show that in human aortic cells (HAECs), rapid activation mitochondrial aldehyde dehydrogenase 2 (ALDH2) mediates ethanol‐induced eNOS by preventing reactive oxygen species (ROS) accumulation. Furthermore, ALDH2 ethanol is due to its hyperacetylation SIRT3 inactivation. These data suggest HAECs may be dependent
Previous studies demonstrated that aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, which eliminates ALDH2 activity down to 1%-6%, is a susceptibility gene for coronary disease. Here we investigated the underlying mechanisms based on our prior clinical and experimental studies. Male apoE-/- mice were transfected with GFP, ALDH2-overexpression ALDH2-RNAi lentivirus respectively (n=20 each) after constrictive collars placed around right common carotid arteries. Consequently, silencing led...
Ginsenoside Compound K (CK) has been recognized as a major functional component that is absorbed into the systemic circulation after oral administration of ginseng. CK demonstrates diverse bioactivities. A phase I clinical study indicated was potential candidate for arthritis therapy. However, II suspended because high cost associated with present manufacturing approach, which based on traditional planting-extracting-biotransforming process. We previously elucidated complete biosynthetic...
Abstract Background Handelin is a bioactive compound from Chrysanthemum indicum L . that improves motor function and muscle integrity during aging in Caenorhabditis elegans This study aimed to further evaluate the protective effects molecular mechanisms of handelin mouse atrophy model induced by cachexia aging. Methods A tumour necrosis factor (TNF)‐α‐induced was used examine activity cultured C2C12 myotubes vitro Lipopolysaccharide (LPS)‐treated 8‐week‐old mice 23‐month‐old (aged) were...
Cell survival or death is critical for cardiac function. Myocardial pyroptosis, as a newly recognized programmed cell death, remains poorly understood in sepsis. In this study, we evaluated the effect of aldehyde dehydrogenase (ALDH2) on myocardial pyroptosis and revealed underlying mechanisms We established septic shock mice model by intraperitoneal injection Lipopolysaccharide (LPS, 15 mg/kg) 12 h before sacrifice. It was found that significantly inhibited NOD-like receptor protein 3...
Previous studies highlighting the pivotal function of S100A8 protein have shown that inflammation and vascular endothelial harm play a major role in deep vein thrombosis (DVT) development, as evidenced by earlier S100 calcium-binding A8 (S100A8). Therefore, we aimed to establish connection between DVT investigate development. Blood specimens were taken from 23 patients with 31 controls. The fluctuation association for interleukin-1 beta (IL-1β) was assessed using enzyme-linked immunosorbent...
Objectives Early evaluation and treatment of patients with acute chest pain pose a massive challenge to the emergency care system worldwide. This study aims determine current burden early management presenting departments (EDs) in China. Design The Evaluation Management Patients Acute ChesT is prospective, multicentre provincially representative registry Chinese EDs. Setting A stratified random sampling design generated province sample 21 public hospitals independent EDs Shandong, Each...
Post-cardiac arrest myocardial dysfunction significantly contributes to early mortality after the return of spontaneous circulation. However, no effective therapy is available now. Aldehyde dehydrogenase 2 (ALDH2) enzyme has been shown protect heart from aldehyde toxicity such as 4-hydroxy-2-nonenal (4-HNE) and oxidative stress. In this study, we evaluated effect enhanced activity or expression ALDH2 on post-cardiac survival in a rat cardiac model. Furthermore, elucidated underlying...
Abstract The involvement of endothelial barrier function in abdominal aortic aneurysm (AAA) and its upstream regulators remains unknown. Single‐cell RNA sequencing shows that disrupted focal junction is an early (3 days) persistent (28 event during Angiotensin II (Ang II)‐induced AAA progression. Consistently, mRNA on human dissection tissues confirmed downregulated expression barrier‐related genes. Aldehyde dehydrogenase 2 (ALDH2), a negative regulator AAA, found to be upregulated the...
// Baoshan Liu 1, 2, 3, 4, * , Jiali Wang Minghua Li 4 Qiuhuan Yuan Mengyang Xue Feng Xu Yuguo Chen 1 Department of Emergency, Qilu Hospital, Shandong University, Jinan, China 2 Chest Pain Center, 3 Key Laboratory Emergency and Critical Care Medicine Province, Cardiovascular Remodeling & Function Research, Chinese Ministry Education Public Health, These authors have contributed equally to this work Correspondence to: Chen, email: chen919085@sdu.edu.cn Xu, xufengsdu@126.com Keywords:...
// Xuexiao Wang 1, * , Jiali Yunlong Jia 1 Yu Xiaonan Han Yuqing Duan Wei Lv Ming Ma 2 Lihua Liu Department of Biotherapy, Fourth Hospital Hebei Medical University and Cancer Institute, Shijiazhuang, China Research Center, These authors have contributed equally to this work Correspondence to: Liu, email: cdlihualiu@aliyun.com Keywords: bridging integrator-1 (Bin1), methylation, esophageal squamous cell carcinoma (ESCC), Decitabine, epithelial mesenchymal transition (EMT) Received: August 15,...