A5100393043- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Food composition and properties
- dental development and anomalies
- Cardiac Ischemia and Reperfusion
- Cancer, Hypoxia, and Metabolism
- Alcohol Consumption and Health Effects
- Phytase and its Applications
- RNA modifications and cancer
- Periodontal Regeneration and Treatments
- Cancer Genomics and Diagnostics
- Pomegranate: compositions and health benefits
- Heart Rate Variability and Autonomic Control
- Biochemical Analysis and Sensing Techniques
- Antioxidant Activity and Oxidative Stress
- Nutrition and Health in Aging
- Oral and Maxillofacial Pathology
- Aluminum toxicity and tolerance in plants and animals
- Signaling Pathways in Disease
- Cancer Risks and Factors
- Vagus Nerve Stimulation Research
- Metabolism, Diabetes, and Cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Nuts composition and effects
Zhejiang University
2020-2025
Qilu Hospital of Shandong University
2019-2025
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
Dongguan People’s Hospital
2024
Jilin University
2018-2023
First Hospital of Jilin University
2018-2023
Wenzhou Medical University
2023
VA Palo Alto Health Care System
2022-2023
Stanford University
2022-2023
Background The association between lung cancer and trace element levels, such as serum copper (Cu) zinc (Zn) levels the Cu:Zn ratio, vary among different demographic groups; however, it is unknown whether variations in Cu Zn ratios are related to prediction prognosis of cancer. We aimed clarify this relationship Han Chinese population Northeast China.Methods recruited 146 patients with age- resident area-matched cancer-free controls.Results Increased ratio were positively associated (OR:...
Abstract Background Among the most common forms of cancer worldwide, breast posed a serious threat to women. Recent research revealed lack oxygen, known as hypoxia, was crucial in forming cancer. This aimed create robust signature with hypoxia-related genes predict prognosis patients. The function hypoxia further studied through cell line experiments. Materials and methods In bioinformatic part, transcriptome clinical information were obtained from Cancer Genome Atlas(TCGA). Hypoxia-related...
The objectives of this study were to: (1) observe the effects drought stress (DS) on structural development endosperm starch granules; (2) investigate DS composition and physicochemical properties starches; (3) compare different responses to between soft hard wheat.DS resulted in large A-type granules at 12 d after anthesis (DAA) a high percentage B-type 18 DAA cells two wheat cultivars. decreased 1000-grain weight, total amylose contents, amylose-to-amylopectin ratio both starches. also...
The objective of this study was to analyze the latent categories fatigue in patients with chronic heart failure (CHF), explore their characteristic differences, and identify associated influencing factors. This cross-sectional included 289 CHF who were enrolled at 2 tertiary-level hospitals Shandong, China, from August December 2023. convenience sampling method used collect data. Furthermore, level fatigue, insomnia, anxiety, depression, social support evaluated using Chinese version...
Abstract Oesophageal squamous cell carcinoma (ESCC) is a common and aggressive malignancy. Although many molecular alterations have been observed in ESCC, the mechanisms underlying development progression of this disease remain unclear. In present study, miR-1224-5p was identified to be downregulated ESCC tissues compared normal tissues, its low expression correlated with shorter survival time patients. vitro experiments showed that inhibited proliferation, colony formation, migration...
Post-cardiac arrest myocardial dysfunction significantly contributes to early mortality after the return of spontaneous circulation. However, no effective therapy is available now. Aldehyde dehydrogenase 2 (ALDH2) enzyme has been shown protect heart from aldehyde toxicity such as 4-hydroxy-2-nonenal (4-HNE) and oxidative stress. In this study, we evaluated effect enhanced activity or expression ALDH2 on post-cardiac survival in a rat cardiac model. Furthermore, elucidated underlying...
Abstract Objective: We retrospectively analyzed the clinical prognostic value of 8th edition American Joint Committee on Cancer (AJCC) staging system for luminal A breast cancer. Methods: Using both anatomic and in AJCC cancer system, we restaged patients with treated at Breast Disease Center, Peking University First Hospital from 2008 to 2014. Follow-up data including 5-year disease free survival (DFS), overall (OS) other clinic-pathological were collected analyze differences between two...
Although wheat (Triticum aestivum L.) pericarp starch granule (PSG) has been well-studied, our knowledge of its features and mechanism accumulation degradation during growth is poor. In the present study, developing caryopses were collected granules extracted from their to investigate morphological structural characteristics PSGs using microscopy, X-ray diffraction Fourier transform infrared spectroscopy techniques. Relative gene expression levels ADP-glucose pyrophosphorylase (APGase),...
Radiotherapy is the primary and most important treatment for nasopharyngeal carcinoma (NPC). Cancer stem-like cells (CSCs) have been shown to be resistant radiation. The phosphatase tensin homolog deleted on chromosome 10 (PTEN) tumor suppressor gene has suggested play a role in stem cell self-renewal. In present study, we sorted PTEN-/+ using flow cytometer. clone formation assay showed that PTEN- were more radioresistant than PTEN+ NPC cells. We found demonstrated significant increase...
Radiotherapy is the most successful nonsurgical treatment for nasopharyngeal carcinoma (NCP). Although NPCs initially respond well to a full course of radiation, recurrence and metastasis are frequent. In this study, we found that down‐regulated c‐MYB expression was associated with increased radiation resistance DNA damage repair ability. Interestingly, over‐expressed in cancer tissues but not adjacent tissues. Down‐regulation inhibited cell proliferation, led cycle arrest at M phase NPC...
Periodontal diseases, which are characterized by destruction of the connective tissues responsible for restraining teeth within jaw, main cause tooth loss. regeneration mediated human periodontal ligament stem cells ( hPDLSC s) may offer an alternative strategy treatment disease. Dogs a widely used large‐animal model study periodontal‐disease progression, tissue regeneration, and dental implants, but little attention has been paid to identification involved in this species. This aimed...
Intervertebral disc degeneration (IDD) constitutes the pathological foundation of most musculoskeletal disorders spine. Previous studies have noted that cell proliferation is a common feature IDD. Bioinformatics indicated aberrantly expressed long non-coding RNAs (lncRNAs) were involved in development In this study, we aimed to investigate function lncRNA HOTAIR human nucleus pulposus (NP) cells IDD vitro and further clarified its mechanism. The expression miR-130b was quantified by qRT-PCR...