A5071755945- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Renal cell carcinoma treatment
- Smart Agriculture and AI
- Spondyloarthritis Studies and Treatments
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Spine and Intervertebral Disc Pathology
- Genetics and Plant Breeding
- Renal and related cancers
- Radiomics and Machine Learning in Medical Imaging
- Seaweed-derived Bioactive Compounds
- Remote Sensing in Agriculture
- Medical Imaging and Analysis
- Gastric Cancer Management and Outcomes
- Brain Tumor Detection and Classification
- Colorectal Cancer Screening and Detection
- Biofuel production and bioconversion
- Sexual function and dysfunction studies
- Rheumatoid Arthritis Research and Therapies
- Leaf Properties and Growth Measurement
- Infectious Diseases and Tuberculosis
Peking University Shenzhen Hospital
2022-2025
Shantou University
2022-2025
Shantou University Medical College
2022-2025
China Agricultural University
2021-2025
University of Hong Kong - Shenzhen Hospital
2024-2025
Guangxi University
2024-2025
Hong Kong University of Science and Technology
2024
University of Hong Kong
2024
China Three Gorges University
2024
University of South China
2017-2024
A better understanding of the extent convergent selection among crops could greatly improve breeding programs. We found that quantitative trait locus KRN2 in maize and its rice ortholog, OsKRN2, experienced selection. These orthologs encode WD40 proteins interact with a gene unknown function, DUF1644, to negatively regulate grain number both crops. Knockout or OsKRN2 increased yield by ~10% ~8%, respectively, no apparent trade-offs other agronomic traits. Furthermore, genome-wide scans...
Background Cancer is a serious threat to the whole of humanity. The Multi-Cancer Early Detection (MCED) test expected solve problem “Universal cancer screening”. purpose this study evaluate MCED value two tests, YiDiXie™-HS and YiDiXie™-SS, in multiple types. Patients methods 11094 subjects were finally included (the malignant tumor group, n = 4405; normal control 6689). group all major solid hematological sensitivity specificity YiDiXie™-SS evaluated, respectively. Results overall for...
Summary Starch is the most abundant storage carbohydrate in maize kernels and provides calories for humans other animals as well raw materials various industrial applications. Decoding genetic basis of natural variation kernel starch content needed to manipulate quantity quality via molecular breeding meet future needs. Here, we identified 50 unique single quantitative trait loci (QTLs) with 18 novel QTLs linkage mapping, joint mapping a genome‐wide association study multi‐parent population...
Ankylosing spondylitis (AS) is a chronic progressive inflammatory disease of the spine and its affiliated tissues. AS mainly affects axial bone, sacroiliac joint, hip spinal facet, adjacent ligaments. We used machine learning (ML) methods to construct diagnostic models based on blood routine examination, liver function test, kidney test patients with AS. This method will help clinicians enhance efficiency allow receive systematic treatment as soon possible.We consecutively screened 348...
Due to a lack of studies on immune-related pathogenesis and clinical diagnostic model, the diagnosis Spinal Tuberculosis (STB) remains uncertain. Our study aimed investigate possible STB develop model for based immune cell infiltration.Label-free quantification protein analysis five pairs specimens was used determine expression intervertebral disc in non-STB. GO enrichment analysis, KEGG pathway were STB. The Hub proteins then eliminated. Four datasets downloaded from GEO database analyze...
Bladder cancer (BC) is one of the ten most common cancers worldwide with late detection and early age diagnosis. There abundant evidence that timely intervention can lead to a better prognosis BC. Substantial has indicated microRNAs (miRNAs) are specific different tumour types remarkably stable, indicating serum miRNAs may serve as potential diagnostic markers. This study aimed identify suitable create panel be used diagnose primary
Increasing planting density is one of the most important strategies for generating higher maize yields. Moderate leaf rolling decreases mutual shading leaves and increases photosynthesis population hence tolerance high-density planting. Few genes that control in have been identified, however, their applicability breeding programs remains unclear. Here we identified a abaxially rolled leaf1 (arl1) mutant with extreme found size bulliform cells within adaxial blade surface increased arl1...
The WD40 repeat proteins are crucial components of eukaryotic genomes and contribute to a wide array plant developmental processes environmental interactions. However, the true extent intraspecific diversity in plants is unclear. We defined nearly complete species-wide pan-WD40ome maize based on published genome sequences 26 nested association mapping (NAM) population founders. largely saturated with inclusion approximately 20 inbred lines, about 95% being present at least two architectural...
Alginate, an important acidic polysaccharide in marine multicellular algae, has attracted attention as a promising biomass resource for the production of medical and agricultural chemicals. Alginate lyase is critical saccharification utilization alginate. Discovering appropriate efficient enzymes depolymerizing alginate into fermentable fractions plays vital role commercial exploitation. Herein, unique lyase, AlgSH7, belonging to 7 family purified characterized from alginate-utilizing...
The accuracy detection of individual citrus fruits in a orchard environments is one the key steps realizing precision agriculture applications such as yield estimation, fruit thinning, and mechanical harvesting. This study proposes an improved object YOLOv5 model to achieve accurate identification counting environment. First, latest visual attention mechanism coordinated module (CA) was inserted into backbone network focus on fruit-dense regions recognize small target fruits. Second,...
Prostate cancer (PCa) remains a worldwide public health problem that poses serious threat to the of men worldwide. Many studies have found microRNA (miRNA) in serum has potential be biomarker for screening. Our study was conducted investigate value miRNAs PCa We selected 12 from past its association with PCa. checked expression levels these 112 patients and healthy controls two-stage experiment. plotted receiver operating characteristic curve validation stage constructed four-miRNA panel...
Introduction The relationship between intervertebral disc degeneration (IVDD) and osteoporosis (OP), diagnosed primarily using bone mineral density (BMD), remains unclear so far. present study, therefore, aimed to investigate the potential Mendelian randomization genome-wide association analyses. Specifically, impact of on development was evaluated. Materials methods studies (GWAS) summary data OP/BMDs IVDD were collected from FinnGen consortium, GEFOS MRC-IEU. OP then explored TSMR....
Maize (Zea mays L. ssp. mays) was domesticated from teosinte parviglumis) about 9000 years ago in southwestern Mexico and adapted to a range of environments worldwide. Researchers have depicted the maize domestication adaptation processes over past two decades, but efforts been limited either sample size or genetic diversity. To better understand these processes, we conducted genome-wide survey 982 inbred lines 190 accessions using 40,000 single-nucleotide polymorphism markers.Population...
Background: Bladder cancer is one of the most prevalent malignancies. Due to disadvantage existing bladder diagnostic tools, miRNAs hold promise as new markers. Materials & methods: A total 224 participants were involved in this three-cohort trial. 15 candidate selected, and with ability screened out quantitative reverse transcription PCR. Diagnostic capability was ascertained by receiver operating characteristic curve area under curve. Bioinformatics analysis constructed for target gene...
Renal cell carcinoma (RCC) is one out of the most universal malignant tumors globally, and its incidence increasing annually. MicroRNA (miRNA) in serum could be considered as a non-invasive detecting biomarker for RCC diagnosis.A total 224 participants (112 patients (RCCs) 112 normal controls (NCs)) were enrolled three-phrase study. Reverse transcription quantitative PCR (RT-qPCR) was applied to reveal miRNA expression levels RCCs NCs. Receiver operating characteristic (ROC) curves area...
Abstract Background Although non-invasive radiological techniques are widely applied in kidney renal clear cell carcinoma (KIRC) diagnosis, more than 50% of KIRCs detected incidentally during the diagnostic procedures to identify (RCC). Thus, sensitive and accurate KIRC methods required. Therefore, this study, we aimed KIRC-associated microRNAs (miRNAs). Methods This three-phase study included 224 participants (112 each patients with healthy controls (NCs)). RT-qPCR was used evaluate miRNA...
Background: Prostate cancer (PCa) is one of the most prevalent malignancies affecting male life cycle. The incidence and mortality prostate are also increasing every year. Detection MicroRNA expression in serum to diagnose determine prognosis a very promising non-invasive modality. Materials method: A total 224 study participants were included our study, including 112 patients healthy adults. experiment consisted three main phases, namely, screening phase, testing validation phase. levels...