A5100446805- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- interferon and immune responses
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- RNA regulation and disease
- Kruppel-like factors research
- Ferroptosis and cancer prognosis
- RNA Interference and Gene Delivery
- Fibroblast Growth Factor Research
- Blood Coagulation and Thrombosis Mechanisms
- Selenium in Biological Systems
- Antimicrobial Peptides and Activities
- Beetle Biology and Toxicology Studies
- Cancer-related Molecular Pathways
- Toxin Mechanisms and Immunotoxins
- Prostate Cancer Treatment and Research
- Plant and Fungal Interactions Research
- Protease and Inhibitor Mechanisms
- Retinoids in leukemia and cellular processes
Qilu Hospital of Shandong University
2024
Shantou University Medical College
2020-2023
Peking University Shenzhen Hospital
2020-2023
Anhui Medical University
2022-2023
Affiliated Hospital of Southwest Medical University
2017-2023
Shantou University
2020-2023
Qingdao Agricultural University
2023
The First People's Hospital of Shunde
2022
Southern Medical University
2022
Lanzhou University
2020
Colon cancer is the most common digestive system malignancy, along with high mortality rate, familial transmissibility and hepatic metastasis. Our study investigated role of long non-coding RNA H19 in colon cancer. We found that was overexpressed tissues cell lines, interference by short hairpin (shRNA) effectively decreased migration invasion cells (HT-29 RKO). Besides, miR-138 predicted a target H19, low expression cells. The silence strongly increased miR-138. level elevated adding mimic...
Recent studies have shown that DNA methylation in the promoter of microRNA-375 (miR-375) downregulates its expression during tumorigenesis. However, it is not known if CpG miR-375 also has a role pathogenesis type 2 diabetes mellitus (T2DM). In this study, level and status patients with T2DM were analyzed. Plasma samples from 100 healthy controls normal glucose tolerance (NGT) collected. The plasma levels examined using quantitative polymerase chain reaction (qPCR) 17 sites determined...
α-Tomatine is a glycoalkaloid found in tomatoes and curcumin major yellow pigment of turmeric. In the present study, combined effect these two compounds on prostate cancer cells was studied. Treatment different with or α-tomatine alone resulted growth inhibition apoptosis concentration-dependent manner. Combinations synergistically inhibited induced PC-3 cells. Effects combination were associated synergistic NF-κB activity potent decrease expression its downstream gene Bcl-2 Moreover, strong...
MicroRNAs (miRNAs) are a class of small noncoding RNA that, through mediating posttranscriptional gene regulation, play critical role in nearly all biological processes. Over the last decade it has become apparent that plant miRNAs may serve as novel functional component food with therapeutic effects including anti-influenza and antitumor. Rapeseed bee pollen good properties enhancing immune function well preventing treating disease. In this study, we identified exogenous from rapeseed mice...
Circulating miRNAs have been proved to be promising biomarkers for disease detection in recent years. The present study aimed at exploring available serum miRNA the of colorectal cancer.A three-phase was performed select and validate candidate with significant dysregulation cancer using quantitative reverse transcription-polymerase chain reaction. This recruited 137 patients 145 healthy controls. diagnostic values were evaluated by receiver operating characteristic analysis. Bioinformatics...
Background: Bladder cancer is one of the most prevalent malignancies. Due to disadvantage existing bladder diagnostic tools, miRNAs hold promise as new markers. Materials & methods: A total 224 participants were involved in this three-cohort trial. 15 candidate selected, and with ability screened out quantitative reverse transcription PCR. Diagnostic capability was ascertained by receiver operating characteristic curve area under curve. Bioinformatics analysis constructed for target gene...
Renal cell carcinoma (RCC) is one out of the most universal malignant tumors globally, and its incidence increasing annually. MicroRNA (miRNA) in serum could be considered as a non-invasive detecting biomarker for RCC diagnosis.A total 224 participants (112 patients (RCCs) 112 normal controls (NCs)) were enrolled three-phrase study. Reverse transcription quantitative PCR (RT-qPCR) was applied to reveal miRNA expression levels RCCs NCs. Receiver operating characteristic (ROC) curves area...
Background: Previous studies have shown that P73 antisense RNA 1T (non-protein coding), also known as TP73-AS1, is a long non-coding (lncRNA) and involved in the development of medulloblastoma. However, regulatory mechanism lncRNA TP73-AS1 medulloblastoma was still unclear, present study aimed to investigate detailed functions regulation Materials methods: The levels miR-494-3p, Eukaryotic initiation factor 5A2 (EIF5A2) were determined using quantitative real-time PCR (qRT-PCR), situ...
The aim of the study was to identify serum microRNAs (miRNAs) as potential biomarkers for screening renal cell carcinoma.The divided into three stages, including stage, training and validation stage. In we examined expression 30 miRNAs from healthy controls (HCs) carcinoma (RCC) patients. We further studied dysregulated in (30 RCC 26 HCs) (73 80 stages. estimated diagnostic value by receiver operating characteristic (ROC) curves area under ROC curve (AUC). Finally, bioinformatics analysis...
Osteosarcoma (OS) is the most common primary bone tumor, with high morbidity in infants and adolescents. Long noncoding RNA LINC00313 has been found to modulate papillary thyroid cancer tumorigenesis be dysregulate lung cancer. However, role of OS not yet addressed.We evaluated mRNA protein expression using real-time quantitative PCR Western blotting. Cell proliferation was MTT; apoptosis autophagy were assessed flow cytometry, blotting, and/or GFP-LC3 assay. Transwell assay conducted...
Aim: Breast cancer, especially invasive ductal carcinoma (IDC), is the cause of a great clinical burden. miRNA could be considered as noninvasive biomarkers for IDC diagnosis. Materials & methods: Two hundred and sixty participants (135 patients 125 healthy controls) were enrolled in three-cohort study. The expression 28 miRNAs serum detected with quantitative reverse transcription-PCR. Bioinformatic analysis was used predicting target genes three selected miRNAs. Results: level seven...
Bladder cancer (BC) is the tenth most common in world. Serum microRNA (miRNA) profiles previously have been reported as non-invasive biomarkers screening. The and reliable diagnostic are urgently needed for detecting BC, while cystoscopy invasive. Our study aimed to identify candidate miRNAs serum potential BC detection.This was including screening stage, training validation stage with 137 patients 127 healthy controls (HCs). We identified expression of 28 from 5 pools 3 HC initial stage....
Abstract Background: Prostate cancer (PCa) is one of the leading causes cancer-related death. In present research, we adopted a comprehensive bioinformatics method to identify some biomarkers associated with tumor progression and prognosis PCa. Methods: Differentially expressed genes (DEGs) analysis weighted gene co-expression network (WGCNA) were applied for exploring modules correlative Clinically Significant Modules distinguished, Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG)...
Cancer stem cells (CSCs) have been characterized by several exclusive features that include differentiation, self-renew, and homeostatic control, which allows tumor maintenance spread. Recurrence therapeutic resistance of head neck squamous cell carcinomas (HNSCC) identified to be attributed CSCs. However, the biomarkers led development HNSCC remain less defined. In this study, we quantified cancer stemness mRNA expression-based index (mRNAsi), found mRNAsi indices were higher in tissues...
Nasopharyngeal carcinoma is cancer with unique epidemiological characteristics, showing obvious ethnicity, gender, and geographical prevalence. More more evidence shows that microRNAs are stable in serum specific to different tumor types. Therefore, miRNA a new non-invasive biomarker for detection.The experiment divided into three stages, namely, the screening stage, training verification stage. We took 54 patients nasopharyngeal 108 healthy controls as research objects. use...
Previous studies have shown that the miR-17-92 cluster is involved in occurrence and development of bladder cancer. However, role serum diagnosis cancer has not been studied. In present study, we evaluated expression members tissues by analyzing 428 cases from TCGA database. Next, collected sera 74 patients 90 controls, used qRT-PCR to detect relative cluster. The results showed were significantly higher than they positively correlated with clinical stage pathological grade patients. We...
Abstract Objective Aberrant activation of Wnt/β‐catenin signalling contributes significantly to the development human colorectal cancers and β‐catenin is key molecule transducing canonical signalling. Therefore, a promising therapeutic target for cancer treatment. This study demonstrates that oncogenic IKK ε kinase phosphorylates restrain its hyper activation, therefore promoting ( CRC ) cell proliferation. Materials methods expression levels in tissues lines were analysed by...
Background: Renal cell carcinoma (RCC) has been a major health problem and is one of the most malignant tumors around world. Serum microRNA (miRNA) profiles previously have reported as non-invasive biomarkers in cancer screening. The aim this study was to explore serum miRNAs potential for screening RCC. Methods: A three-phase conducted In phase, 12 candidate related RCC were selected further by ENCORI database with 517 patients 71 NCs. total 220 participants [108 112 normal controls (NCs)]...