A5012968988- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- MicroRNA in disease regulation
- Uterine Myomas and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Reproductive Health and Contraception
- Radiomics and Machine Learning in Medical Imaging
- Occupational and environmental lung diseases
- Esophageal and GI Pathology
- Erythrocyte Function and Pathophysiology
- Gynecological conditions and treatments
- Circular RNAs in diseases
- Thyroid Disorders and Treatments
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- DNA Repair Mechanisms
- Thyroid Cancer Diagnosis and Treatment
- Iron Metabolism and Disorders
- Cancer-related gene regulation
- Human Health and Disease
- Carcinogens and Genotoxicity Assessment
- Cancer, Lipids, and Metabolism
- Acute Lymphoblastic Leukemia research
- Air Quality and Health Impacts
- Ovarian function and disorders
Qilu Hospital of Shandong University
2015-2023
Shandong University
2015
Jiangsu Province Hospital
2010
Beijing Obstetrics and Gynecology Hospital
1986-2003
Beijing United Family Hospital
1986
Background: The interaction between tumor cells and inflammatory has not been systematically investigated in esophageal squamous cell carcinoma (ESCC).The aim of the present study was to evaluate whether preoperative lymphocyte-monocyte ratio (LMR), neutrophil-lymphocyte (NLR), platelet-lymphocyte (PLR) could predict prognosis ESCC patients undergoing esophagectomy.Materials Methods: Records from 218 with histologically diagnosed who underwent attempted curative surgery January 2007 December...
Accumulating evidence indicates that dysregulated microRNA-146a (miR-146a) is involved in tumour genesis and cancer progression. We aimed to evaluate its expression level the potential for diagnosis prognosis oesophageal squamous cell (ESCC). examined miR-146a 62 pairs of ESCC cancerous matched paracancerous tissue, 115 formalin-fixed paraffin-embedded (FFPE) tissue samples serum from 154 patients healthy volunteers using quantitative reverse transcription–PCR (qRT–PCR). Kaplan–Meier method,...
The objective of this study was to investigate the clinical significance systemic inflammation score (SIS) and prognostic nutritional index (PNI) in esophageal squamous cell carcinoma (ESCC) patients who underwent esophagectomy. Records from 206 with histologically diagnosed ESCC esophagectomy at Qilu Hospital Shandong University January 2007 December 2008 were retrospectively reviewed. median disease-free survival (DFS) cohort 32.3 months 5-year DFS 34.5 %. overall (OS) 39.5 OS 40.8 We...
MicroRNA-613 (miR-613) plays important roles in tumorigenesis and cancer progression. We aimed to evaluate its expression level potential for diagnosis prognosis esophageal squamous cell (ESCC). examined miR-613 60 pairs of ESCC cancerous matched paracancerous tissues, serum samples from 75 patients healthy volunteers, 105 formalin-fixed paraffin-embedded (FFPE) tissue using quantitative reverse transcription polymerase chain reaction. Receiver-operating characteristic (ROC) curve analysis,...
This study was to evaluate the prognostic significance of serum lipids in esophageal squamous cell carcinoma patients who underwent esophagectomy. Preoperative were collected from 214 diagnosed with carcinoma. All received esophagectomy Qilu Hospital Shandong University January 2007 December 2008. The records and data analyzed retrospectively. We found that low total cholesterol (for T stage, p = 0.006; for TNM 0.039) low-density lipoprotein 0.031; 0.035) associated advanced stage stage....
Abstract We aimed to examine Notch2 expression in oesophageal squamous cell carcinoma (ESCC) patients and evaluate its prognostic potential. Immunohistochemical (IHC) staining, quantitative real-time polymerase chain reaction (qRT-PCR) western blot analysis were utilized investigate the status value. Furtherly, CCK8 clonogenic assays conducted determine if inhibition by shRNA could lead a decrease proliferation survival of ESCC cells. A notably higher level was found tissues at mRNA ( P <...
The objective of this study was to investigate the prognostic value peripheral blood monocytes in esophageal squamous cell carcinoma (ESCC) patients who underwent esophagectomy. Records from 218 consecutive with histologically diagnosed ESCC esophagectomy at Qilu Hospital Shandong University January 2007 December 2008 were retrospectively reviewed. median disease-free survival (DFS) cohort 29.0 months, and 5-year DFS rate 34.4%. overall (OS) 35.0 OS 37.6%. cut-off 0.42 × 109/L for absolute...
We aimed to value the diagnostic potential of serum miR-1297 in esophageal squamous cell cancer (ESCC). Its expression level was detected 156 pairs patients with ESCC and healthy volunteers using quantitative real-time polymerase chain reaction (qRT-PCR) method. It statistically decreased compared controls. AUC based on 0.840 ± 0.035 discovery group 0.837 0.034 validation group. Further analysis early-stage revealed that 0.819 0.053 0.814 0.044 sensitivity specificity were promising. In...
We aimed to investigate the pattern of expression and clinical significance isocitrate dehydrogenase 1(IDH1) in esophageal squamous cell carcinoma (ESCC). The IDH1 was determined by quantitative real-time polymerase chain reaction, immunohistochemistry, Western blot analysis using 38 pairs frozen tissues. Enzyme-linked immunosorbent assay employed measure 67 serum samples from patients their controls evaluate its diagnostic value. Immunohistochemistry 111 formalin-fixed paraffin embedded...
// Xiaochen Huang 1, * , Shanghui Guan Jiangfeng Wang 1 Linli Zhao Yibin Jia Zilong Lu 2 Cuiping Yin 3 Shengsi Yang Qingxu Song Lihui Han Cong Jingyi Li Wei Zhou Xiaolei Guo and Yufeng Cheng Department of Radiation Oncology, Qilu Hospital Shandong University, Jinan 250012, Shandong, China Noncommunicable Disease Control Prevention, Center for 250014, Rehabilitation, These authors have contributed equally to this work should be considered as co-first Correspondence to: Cheng, email:...
Glioblastoma multiforme (GBM) is one of the most common and aggressive brain tumors. The microenvironment GBM characterized by its highly immunosuppressive nature with infiltration cells expression levels cytokines. Efferocytosis a biological process in which phagocytes remove apoptotic vesicles from tissues. plays noticeable function formation environment. This study aimed to develop an efferocytosis-related prognostic model for GBM. bioinformatic methods were utilized analyze...