A5100621496- Circular RNAs in diseases
- Breast Cancer Treatment Studies
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Breast Lesions and Carcinomas
- Cancer Cells and Metastasis
- Global Cancer Incidence and Screening
- Air Quality and Health Impacts
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- Metastasis and carcinoma case studies
- High Altitude and Hypoxia
- RNA Interference and Gene Delivery
- Metabolomics and Mass Spectrometry Studies
- Signaling Pathways in Disease
- Phytochemical compounds biological activities
- Ginseng Biological Effects and Applications
- Bioactive Compounds and Antitumor Agents
- Toxic Organic Pollutants Impact
- Glycosylation and Glycoproteins Research
- Traditional Chinese Medicine Analysis
- Adipose Tissue and Metabolism
- Phytochemistry and Bioactive Compounds
- Cancer-related gene regulation
- Biological and pharmacological studies of plants
Beijing Institute of Technology
2023-2025
Zhejiang Cancer Hospital
2013-2023
University of Chinese Academy of Sciences
2020-2023
Shanghai Medical College of Fudan University
2020-2021
Fudan University Shanghai Cancer Center
2020-2021
Cancer Hospital of Chinese Academy of Medical Sciences
2020
Beijing Chao-Yang Hospital
2019
Capital Medical University
2019
Qilu Hospital of Shandong University
2017
Shandong University
2016
High-energy boron-based fuel aluminum-diboride (AlB2) has attracted much attention in the field of solid propellants. However, low reactivity AlB2 hindered its further application. In this study, highly reactive AlB2@hydroxyl-terminated perfluoropolyether alcohol (AlB2@HTPFA) composites with a core–shell structure were prepared by coating functionalized fluoropolymers using facile one-step situ polymerization method. AlB2@HTPFA varying polymer contents (0, 5, 10, and 15 wt%) obtained. The...
Ginsenoside Rd (Rd), one of the main active ingredients in Panax ginseng, has multifunctional activity via different mechanisms and neuroprotective effects that are exerted probably its antioxidant or free radical scavenger action. However, on spinal cord mitochondrial dysfunction underlying still obscure. In this study, we sought to investigate vitro integrity redox balance isolated mitochondria. We verified Ca2+ dissipated membrane potential, provoked swelling decreased NAD(P)H matrix...
Abstract Accumulating evidence suggests that noncoding RNAs play a vital role in cancer biology. Circular (circRNAs), newly defined class of endogenously widespread RNAs, have been intensively reported to influence cell function and development, even prognosis by sponging microRNAs various types cancer. Nevertheless, the circRNAs research hepatocellular carcinoma (HCC) still remains far insufficient. Herein, we investigated circRNAs, circ_0005075, HCC development. We found circ_0005075 was...
Abstract Esophageal cancer (ECa) remains a major cause of mortality across the globe. The expression EIF3J-AS1 is altered in plethora tumors, but its role ECa development and progression are undefined. Here, we show that up-regulated correlates with advanced TNM stage (P = 0.014), invasion depth 0.001), positive lymph node metastasis < 0.001) poor survival (OS: P 0.0059; DFS: 0.0037) ECa. Functional experiments showed knockdown inhibited growth through vitro vivo experiments. Regarding...
Abstract Aim To investigate the impact of biological subtypes in locoregional recurrence Chinese breast cancer patients receiving postmastectomy radiotherapy (PMRT). Methods and Materials About 583 who received radiation between 2010 2012 were retrospectively analyzed. According to immunohistochemical staining profile, classified into: Luminal A‐like, B‐like, HER2‐positive, triple‐negative (TNBC). Local regional (LRR) cumulative incidences calculated by competing risks methodology power...
Abstract Background Ductal carcinoma in situ with microinvasion (DCISM) represents ~1% of all breast cancer cases and is arguably a more aggressive subtype ductal (DCIS). Lacking studies large population, the survival outcomes DCISM are still poorly understood treatment recommendations remain controversial. This study aims to investigate long‐term outcome patients DCISM, potential risk factors for their prognosis, difference between treated breast‐conserving surgery plus radiotherapy (BCT +...
// Xiaochen Huang 1, * , Shanghui Guan Jiangfeng Wang 1 Linli Zhao Yibin Jia Zilong Lu 2 Cuiping Yin 3 Shengsi Yang Qingxu Song Lihui Han Cong Jingyi Li Wei Zhou Xiaolei Guo and Yufeng Cheng Department of Radiation Oncology, Qilu Hospital Shandong University, Jinan 250012, Shandong, China Noncommunicable Disease Control Prevention, Center for 250014, Rehabilitation, These authors have contributed equally to this work should be considered as co-first Correspondence to: Cheng, email:...
The aim of this study was to identify prognostic significance microRNA-100 (miR-100) in solid tumor.Literature search conducted databases such as PubMed, Embase, and Web Science, using the following words "(microRNA-100 OR miR-100 mir100) AND (tumor neoplasm cancer carcinoma malignancy)." updated up until July 10, 2016. Newcastle-Ottawa scale used evaluate quality studies. Pooled hazard ratio (HR) with 95% confidence interval (CI) for patients' survival calculated by a fixed-effects or...
Two new flavanols, (8S,9R)-9,10-dihydro-5,9-dihydroxy-8-(3,4,5-trimethoxyphenyl)-2H,8H-benzo[1,2-b:3,4-b′]dipyran-2-one (1) and (2S,3R)-3,4-dihydro-3,5-dihydroxy-2-(3,4,5-trimethoxyphenyl)-2H,8H-benzo[1,2-b:3,4-b′]dipyran-8-one (2), were isolated from the stems of Glycosmis pentaphylla. The structures these compounds determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D- 2D-NMR) analyses. cytotoxic activities evaluated using MTT method. results showed that 1 2 exhibited considerable...
Acute myocardial ischaemia is a common acute disease and cause of sudden death. However, it difficult to diagnose in patients who died within 6 hours after the onset ischaemia. The occurrence cardiac death often has pathological basis primary heart diseases, which may lead series changes metabolism gene expression.1 Recent research found that hypoxia inducible factor 1 alpha (HIF-1α) sensitive marker hypoxia; its expression upregulated several minutes ischaemia, followed by upregulation...
The role of adjuvant postmastectomy radiotherapy (PMRT) remains controversial for patients with pT3N0M0 breast cancer, especially when are treated the updated chemotherapy. Our study aimed to compare locoregional recurrence-free survival (LRFS), disease-free (DFS), and cancer-specific (BCSS) in without radiotherapy.Between October 2000 8 September 2016, database Breast Cancer Center Shanghai yielded 114 node-negative non-metastatic cancer larger than 5 cm. Univariate multivariate analyses...
Cluster of differentiation 147 (CD147) overexpression plays a key role in the proliferation, differentiation, invasion, metastasis, and prognosis hepatocellular carcinoma (HCC). The aim this study was to explore relationship between rs6757 HCC risk South Chinese population, functional significance by affecting efficacy microRNA-3976 (miR-3976) binding CD147 3'-UTR.We performed retrospective case-control analyze association HCC. We chose candidate microRNAs with potential interacting through...
Objective To detect the expressions of microRNA-126 (miR-126) and microRNA-7 (miR-7) in esophageal squamous cell carcinoma (ESCC) to analyze their correlations with clinicopathologic features prognosis ESCC.Methods The miR-126 miR-7 116 ESCC samples matched normal tissue were detected by real-time PCR.Statistical analysis was used find relationships among miR-7,pathological characteristics prognosis.Results Low expression,normal expression high found 73 (62.9％),35 (30.2％) 8 (6.9％)...
Abstract The two new flavonols exhibit significant cytotoxic activities against HL‐60 and A549 cell lines.
Studies investigating surgery for second primary non-small cell lung cancer (SP) patients are rare. The aim of this study was to explore the effects surgical methods and regional lymph node (LN) dissection on cancer-specific mortality (LCSM) in stage I SP following first (FP).Data diagnosed with after FP were extracted from Surveillance, Epidemiology, End Results (SEER) database. Cumulative incidence function (CIF) curves, a competing risk model propensity score matching (PSM) adopted...
Phenolic compounds and transition metals exist in wastewater having a large number of emissions due to the discharge polluted from explosive industry. And these two substances are important factors that affect generation persistent free radicals (PFR). However, more toxic harmful PFR is unclear In this study, dissociation reaction phenol on metal oxides ZnO form has been explored by density functional theory (DFT) calculation. The surface an exothermic barrierless process, which indicates...
Abstract Background The role of adjuvant postmastectomy radiotherapy (PMRT) remains controversial for patients with pT3N0M0 breast cancer after mastectomy, especially when were treated the updated chemotherapy and much more advanced radiation technology. present analysis compared locoregional recurrence-free survival (LRFS), disease-free (DFS), cancer-specific (BCSS) in stratified by PMRT use. Methods Between October 2000 8 September 2016, database Breast Cancer Center Shanghai yielded 114...