A5004615488- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Inflammatory Biomarkers in Disease Prognosis
- Berberine and alkaloids research
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Sepsis Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Chemical synthesis and alkaloids
- Immune cells in cancer
- Caveolin-1 and cellular processes
- S100 Proteins and Annexins
- Blood Pressure and Hypertension Studies
- Bioactive Natural Diterpenoids Research
- Chronic Kidney Disease and Diabetes
- Extracellular vesicles in disease
- Hippo pathway signaling and YAP/TAZ
- Cancer, Lipids, and Metabolism
- Inflammatory mediators and NSAID effects
- Gastric Cancer Management and Outcomes
Chengdu University of Traditional Chinese Medicine
2024
Shandong University
2014-2023
Qilu Hospital of Shandong University
2014-2023
Shandong Provincial Hospital
2018
Currently, none of the available colorectal adenocarcinoma (CAC) testing has been established as a well-accepted diagnosis tool, particularly for early stage CAC. The recent discovery serum microRNA (miRNA) profile provided new auxiliary approach tumour diagnosis. Our study is involved in global analysis miRNAs during normal–colorectal adenoma (CA)–CAC sequence. Serum samples were collected from 307 CAC patients, 164 CA patients and 226 healthy controls. Differentially expressed screened...
microRNA-210 (miR-210), the master hypoxamir, is overexpressed and generally exhibits oncogenic properties in most human solid tumours, including colorectal cancer (CRC). However, status of circulating miR-210 CRC still unknown. This study aims to assess clinical significance CRC. Using (reverse transcription quantitative PCR) RT-qPCR analysis, we compared expression levels serum 268 patients 102 healthy controls, found that was significantly higher than controls (P < 0.001). The area under...
Our previous study indicates that leptin enhances gastric cancer (GC) invasion. However, the exact effect of on GC metastasis and its underlying mechanism remain unclear. Intercellular adhesion molecule-1 (ICAM-1), a major molecule in stabilising cell–cell cell–extracellular matrix interactions, is overexpressed has crucial roles tumour metastasis. Here, we investigated ICAM-1 expression tissues. Furthermore, characterised influence cells elucidated mechanism. Leptin were tissues, strong...
The objective of this study was to investigate the prognostic value peripheral blood monocytes in esophageal squamous cell carcinoma (ESCC) patients who underwent esophagectomy. Records from 218 consecutive with histologically diagnosed ESCC esophagectomy at Qilu Hospital Shandong University January 2007 December 2008 were retrospectively reviewed. median disease-free survival (DFS) cohort 29.0 months, and 5-year DFS rate 34.4%. overall (OS) 35.0 OS 37.6%. cut-off 0.42 × 109/L for absolute...
Introduction Isthmin-1 (Ism-1) is a novel adipokine. However, little known regarding the association between Ism-1 and type 2 diabetes mellitus (T2DM). This study aimed to investigate relationship serum levels glomerular filtration rate (GFR) in patients with T2DM. Research design methods A total of 209 T2DM were recruited into this retrospective study. Clinical data collected. Fasting blood samples collected for testing using ELISA kits. Based on estimated (eGFR), participants divided...
<h3>Background</h3> Immune checkpoint blockage (ICB) has become a standard-of-care treatment for various tumor types. While the clinical benefits of PD-1 inhibition are well established, combining it with CTLA-4 demonstrated enhanced efficacy. However, anti-CTLA-4 agents also induces significant immune-related adverse events (irAEs), thus restricting its anti-tumor effect. One strategy to overcome this problem is build bispecific molecules aiming 1) attenuate arm balance immune-toxicity and...
肿瘤微环境（tumor microenvironment，TME）与肿瘤的生存和发展密切相关。在TME中，巨噬细胞和中性粒细胞均具有促进肿瘤进展和转移的作用，且两者之间可能存在不同程度的相互作用。目前，越来越多的研究证实，肿瘤的发生与发展不仅是肿瘤细胞的基因突变所致，还与突变细胞对TME的适应过程有关。在临床实践中，开发出能同时靶向肿瘤细胞和TME的新治疗策略，将会为肿瘤的治疗指明新的方向。.