A5100332285- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Diet and metabolism studies
- Electrospun Nanofibers in Biomedical Applications
- Microbial Community Ecology and Physiology
- Cancer-related molecular mechanisms research
- Bone health and treatments
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- Geotechnical Engineering and Soil Mechanics
- Metabolism, Diabetes, and Cancer
- Nutrition and Health in Aging
- Circular RNAs in diseases
- RNA modifications and cancer
- Gut microbiota and health
- Genomics and Phylogenetic Studies
- Adipose Tissue and Metabolism
- Parathyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Thyroid Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- S100 Proteins and Annexins
- Vitamin D Research Studies
- Advanced Vision and Imaging
- Optical measurement and interference techniques
Qilu Hospital of Shandong University
2013-2024
Southeast University
2023
Shandong University
2015-2023
First Affiliated Hospital of Zhengzhou University
2017-2023
Zhengzhou University
2020-2023
East China University of Science and Technology
2022-2023
State Key Laboratory of Chemical Engineering
2023
Xi'an Jiaotong University
2022
Affiliated Hospital of Southwest Medical University
2022
Northwest A&F University
2021-2022
Reactive oxygen species (ROS) play key roles in soil biogeochemical processes, yet the occurrence and accumulation of ROS rhizosphere are poorly documented. Herein, we first developed a ROS-trapping membrane to situ determine ryegrass then quantified temporal spatial variations representative (i.e., O2•─, H2O2, •OH). Fluorescence imaging clearly visualized production rhizosphere. Both O2•─ H2O2 content increased declined throughout life cycle ryegrass, while •OH concentration decreased...
Objective . To investigate changes in the glycated hemoglobin A1c (A1c) level and those β cell function insulin resistance newly diagnosed drug naive type 2 diabetes patients to evaluate relationship between them. Design Methods A total of 818 diabetic individuals who were ≥40 years age recruited. The subjects grouped by values (<6.5%, 6.5–7%, 7-8%, 8-9%, ≥9%). homeostasis model assessment (HOMA) was used pancreatic (HOMA- ) (HOMA-IR). ANOVA,<mml:math...
Overweight or obesity in post-menopausal women is known to induce metabolic disorders associated with neuroinflammation. α-lipoic acid (α-LA), which has been clinically used treat diabetic peripheral neuropathy, found exert anti-inflammatory and neuroprotective effects patients Alzheimer's disease (AD). In this study, investigate the of α-LA on neuroinflammatory factors levels hippocampal brain-derived neurotrophic factor (BDNF) ovariectomized rats fed a high-fat diet (HFD), Wistar were HFD...
Isthmin-1 (Ism-1), as a novel adipokine, plays role in glucose homeostasis and lipid metabolism. However, the relationship between Ism-1 type 2 diabetes mellitus (T2DM) remains unclear. This study aims to investigate association of serum levels with albuminuria insulin resistance patients T2DM preserved renal function.A total 150 were recruited. The presence was evaluated by urinary albumin:creatinine ratio (UACR) first morning urine sample. Serum tested ELISA. Homeostasis model assessments...
Isthmin-1 (Ism-1) is a newly identified insulin-like adipokine that increases glucose uptake by adipocytes and inhibits hepatic lipid synthesis. Recent studies have shown Ism-1 can improve the metabolic disorders associated with type 2 diabetes mellitus (T2DM) metabolism. The classic function of high-density lipoprotein cholesterol (HDL-C) to transport from extra-hepatic tissues liver for In contrast, metabolism inflammation are leading causes atherosclerosis (As). Atherosclerosis often...
Abstract Glucagon receptor (GCGR) agonism offers potentially greater effects on the mitigation of hepatic steatosis. However, its underlying mechanism is not fully understood. Here, it screened tetraspanin CD9 might medicate GCGR agonist. decreased in fatty livers patients and upregulated upon activation. Deficiency liver exacerbated diet‐induced steatosis via complement factor D (CFD) regulated acid metabolism. Specifically, modulated synthesis oxidation genes through regulating CFD...
To investigate the effects of exenatide on renal injury in streptozotocin-induced diabetic rats.Fifty SD rats were randomly divided into normal control, model, exenatide-1, exenatide-2 and exenatide-3 groups, 10 each group. The nephropathy model was constructed later 4 groups. Then, 3 groups treated with 2, 8 μg/kg for weeks, respectively. serum urine biochemical indexes oxidative stress inflammatory tissue determined.Compared to group, group fasting plasma glucose hemoglobin A1c levels...
Abstract Osteoporosis is a systemic metabolic bone disorder for which inflammatory cytokines play an important role. To develop new osteoporosis treatments, strategies improving the microenvironment osteoblast and osteoclast balance are needed. Tumor necrosis factor-α (TNF-α) plays role in initiation development of osteoporosis. Atsttrin engineered protein derived from growth factor, progranulin (PGRN). The present study investigates whether affects formation formation. Here we show inhibits...
Metabolic diseases such as obesity and diabetes induce lipotoxic cardiomyopathy, which is characterized by myocardial lipid accumulation, dysfunction, hypertrophy, fibrosis mitochondrial dysfunction. Here, we identify that glycerol 3-phosphate dehydrogenase (mGPDH) a pivotal regulator of cardiac fatty acid metabolism function in the setting cardiomyopathy. Cardiomyocyte-specific deletion mGPDH promotes high-fat diet induced pathological fibrosis, accumulation. Mechanically, deficiency...
Introduction Isthmin-1 (Ism-1) is a novel adipokine. However, little known regarding the association between Ism-1 and type 2 diabetes mellitus (T2DM). This study aimed to investigate relationship serum levels glomerular filtration rate (GFR) in patients with T2DM. Research design methods A total of 209 T2DM were recruited into this retrospective study. Clinical data collected. Fasting blood samples collected for testing using ELISA kits. Based on estimated (eGFR), participants divided...
SHORT syndrome (short stature, hyperextensibility, ocular depression [deeply set eyes], Rieger anomaly and teething delay) is very rare, with a few cases reported in the literature. We report case of novel PIK3R1 mutation (c.2008delT) complicated severe insulin resistance. Although no treatment guidelines are available to relieve resistance syndrome, our plans, including lifestyle intervention combined metformin pioglitazone, were carried out for this patient. After intervention,...
The clinical presentation of primary hyperparathyroidism (PHPT) differs between patients from developed and developing countries. In China, the pattern has changed over past few decades. Our aim was to elucidate general changes in characteristics PHPT 2010 2021. We enrolled 343 with at Qilu Hospital Shandong University, Jinan, January May 2021, including both surgical non-surgical patients. Patients were divided into two subgroups, 2010-2016 (group A, n = 152) 2017-2021 B, 191), based on...
This paper is aimed to solve the overlearning problem of neural network algorithm used calculate asphalt concrete pavement structural modulus in reverse. The firefly was adapted optimize selection support vector machine (SVM) parameters. Based on optimized SVM model, a new method for dynamic inversion semirigid base layer presented. results show that absolute value relative error each not more than 3.73% by using proposed method. Then, influences temperature and humidity seasonal frozen area...