A5015941282- Pituitary Gland Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Chronic Kidney Disease and Diabetes
- PARP inhibition in cancer therapy
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Circular RNAs in diseases
- Growth Hormone and Insulin-like Growth Factors
- Diabetes Management and Research
- Cancer, Hypoxia, and Metabolism
- Chemokine receptors and signaling
- Neuroendocrine Tumor Research Advances
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- TGF-β signaling in diseases
- Bone Metabolism and Diseases
- Cerebrovascular and Carotid Artery Diseases
- Adrenal and Paraganglionic Tumors
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Regulation of Appetite and Obesity
- Immunotherapy and Immune Responses
Beijing Institute of Neurosurgery
2013-2025
Capital Medical University
2014-2025
Beijing Tian Tan Hospital
2025
Beijing Shijitan Hospital
2024
Yuhuangding Hospital
2015-2023
Qilu Hospital of Shandong University
2011-2022
Shandong University
2011-2022
Nanchong Central Hospital
2018-2020
North Sichuan Medical University
2020
Hainan Medical University
2020
The tumor-promoting chemokine CCL5 has been implicated in malignant transformation of breast epithelial cells, with studies to date focusing mainly on basal-type cancers. In this study, we investigated the consequences deletion MMTV-PyMT transgenic mouse model luminal cancer. model, primary tumor burden and pulmonary metastases were reduced significantly CCL5-deficient subjects, an effect found be associated a deficit Th2 (IL4⁺CD4⁺ T) cells. Mechanistic investigations revealed that activates...
Pituitary neuroendocrine tumors (PitNETs) are one of the most common types intracranial tumors. Currently, cellular characteristics normal pituitary and various other PitNETs still not completely understood.
Plasmid-encoded toxin-antitoxin (TA) systems are known for their role in plasmid maintenance via post-segregational killing. Here, we identified an inactive type II TA system, MtvT/MtvA (MtvTA), encoded on the conjugative pPAD8 from clinical Pseudomonas aeruginosa strain PAD8. Despite its annotation as a toxin, MtvT exhibited no detectable toxicity our assays. Interestingly, deletion of MtvTA significantly increased transfer efficiency PAD8 to P. PAO1. Functional assays revealed that complex...
Glucagon-like peptide 1 (GLP-1), a gut-derived peptide, has been reported to have profound effects on metabolism and reduce insulin resistance. Adipocyte hyperplasia stimulated by preadipocyte differentiation positive effect adipose tissue sensitivity. However, it remains less clear whether GLP-1 plays role in adipogenesis. In this study, we examined the of investigated mechanisms that may be involved effect. our 3T3-L1 cell tested levels adipocyte-specific markers signaling pathways during...
Abstract The genetic basis and corresponding clinical relevance of prolactinomas remain poorly understood. Here, we perform whole genome sequencing (WGS) on 21 patients with to detect somatic mutations then validate the digital polymerase chain reaction (PCR) analysis tissue samples from 227 prolactinomas. We identify same hotspot mutation in splicing factor 3 subunit B1 ( SF3B1 R625H ) 19.8% These mutant display higher prolactin (PRL) levels p = 0.02) shorter progression-free survival (PFS)...
microRNA (miR)-92b is an oncogenic miRNA. F-box and WD-40 domain protein 7 (FBXW7/hCdc4) a tumor suppressor target of miR-92b-3p. This study was designed to investigate the effect miR-92b-3p on colorectal carcinoma (CRC) invasion. The expression levels in human HT29, HCT116, fetal colon (FHC) normal cells were detected. HT29 HCT116 transfected with either inhibitor or FBXW7 plasmids (pcDNA-FBXW7) combination siRNA-FBXW7. Cell viability, migration, invasion, colony formation, cell cycle,...
Inflammation plays an important role in atherosclerosis. Arginase I (Arg I) promotes the proliferation of vascular smooth muscle cells; however, effect Arg on inflammation remains unknown. The present study investigated vitro and vivo.Quantitative reverse transcription-polymerase chain reaction Western blot analysis demonstrated that inhibited tumor necrosis factor-α production induced by lipopolysaccharide human aortic cells. Inducible nitric oxide synthase substrate competition nuclear...
Abstract Atherosclerosis begins as local inflammation of arterial walls at sites disturbed flow, such vessel curvatures and bifurcations with low shear stress. c-Jun NH 2 -terminal kinase (JNK) is a major regulator flow-dependent gene expression in endothelial cells atherosclerosis. However, little known about the vivo role JNK stress We aimed to observe effect on stress-induced atherogenesis apolipoprotein E-deficient (ApoE −/− ) mice investigate potential mechanism human umbilical vein...
Objective . To investigate changes in the glycated hemoglobin A1c (A1c) level and those β cell function insulin resistance newly diagnosed drug naive type 2 diabetes patients to evaluate relationship between them. Design Methods A total of 818 diabetic individuals who were ≥40 years age recruited. The subjects grouped by values (<6.5%, 6.5–7%, 7-8%, 8-9%, ≥9%). homeostasis model assessment (HOMA) was used pancreatic (HOMA- ) (HOMA-IR). ANOVA,<mml:math...
Advances in the understanding of growth hormone-producing adenomas (GHomas) are ongoing, but current therapy is limited by moderate and variable efficacy need life-long treatment. In this study, molecular signaling pathway related to GHoma was investigated proteomics transcriptomics. The differentially expressed proteins genes were significantly enriched Extracellular Matrix-Receptor Interactions, Notch Signaling, Basal Cell Carcinoma JAK-STAT3, Wnt Signaling Glioblastoma Multiforme...
Pituitary adenomas exhibit a wide range of behaviors. The prediction invasion or malignant behavior in pituitary remains challenging. objective the present study was to identify genetic abnormalities associated with sporadic adenomas. In study, exomes six invasive (IPA) and non‑invasive (nIPA) were sequenced by whole‑exome sequencing. Variants confirmed dideoxynucleotide sequencing, candidate driver genes assessed an additional 28 A total 15 identified variants mainly angiogenesis,...
Abstract Aims The aims of this study were to evaluate the associations metabolic abnormalities with incident diabetic kidney disease (DKD) and explore whether dyslipidaemia, particularly high fasting triglyceride (TG), was associated development DKD. Methods In total, 11 142 patients new‐onset type 2 diabetes baseline estimated glomerular filtration rates (eGFR) ≥60 mL/min/1.73 m followed up during 2011‐2016. Incident DKD defined as eGFR <60 at follow‐up. Multiple logistic regression...
Pituitary tumors are monoclonal adenomas that account for about 10-15% of intracranial tumors.Cyclin-dependent kinase 5 (CDK5) regulates the activities various proteins and cellular processes in nervous system, but its potential roles pituitary poorly understood.The activity CDK5 requires association with an activating protein, p35 (also known as activator 1, p35).Here, we show functional CDK5, associated p35, is present normal human tumors.Furthermore, mRNA protein levels were higher than...
Circular RNAs (circRNAs), a group of covalently closed non-coding RNAs, serve critical regulatory roles in many human cancers, including oral squamous cell carcinoma (OSCC). The purpose this study was to investigate the functional role circular RNA ITCH (circ-ITCH) OSCC and underlying mechanisms.RT-qPCR analysis applied detect expression levels circ-ITCH tissues lines. MTT assay flow cytometer were used evaluate effects overexpression on proliferation apoptosis cells. Bioinformatics...
A bone-invasive pituitary adenoma exhibits aggressive behavior, leading to a worse prognosis. We have found that TNF-α promotes bone invasion by facilitating the differentiation of osteoclasts, however, before invades tissue, it needs penetrate dura mater, and this mechanism is not yet clear.
Background: Atherosclerosis begins as local inflammation of vessels at sites disturbed flow, where low shear stress (LSS) leads to mechanical irritation and plaque development progression. Nuclear enzyme poly(ADP-ribose) polymerase 1 (PARP-1) is associated with the response during atherosclerosis. We investigated role underlying mechanism PARP-1 in LSS-induced human umbilical vein endothelial cells (HUVECs). Methods results: HUVECs were simulated by LSS (0.4 Pa). expression was inhibited...
LncRNA MAFG-AS1 is predicted to interact with miR-146a, which can target Toll-like receptor 4 (TLR4), a key player in periodontitis. This study aimed investigate the roles of It was observed that downregulated human periodontal ligament stem cells (PDLSCs) derived from periodontitis-affected teeth. Dual-luciferase assay revealed co-transfection expression vector and miR-146a mimic showed significantly lower relative luciferase activity comparing negative control (NC) miRNA. However, failed...
Objective To investigate the relationship between lipid profiles [including total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C) and high-density (HDL-C)] a mild decline in estimated glomerular filtration rate (eGFR) subjects with normal serum levels. Design Methods In this study, we included 2647 participants who were ≥40 years old had The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was used to estimate GFR. A mildly reduced eGFR defined as...
Objective To investigate how the glucose variability between fasting and a 2-h postload state (2-h plasma [2hPG]-fasting [FPG]) is associated with chronic kidney disease (CKD) in middle-aged elderly Chinese patients previously diagnosed type 2 diabetes. Design Methods This cross-sectional study included 1054 diabetes who were 40 years of age older. First, subjects divided into two groups based on glycated hemoglobin (HbA1c) value 7%. Each group was subgroups, or without CKD. The Chronic...
Background Insulin resistance (IR) plays an important pathophysiological role in the development of diabetes, dyslipidemia, hypertension, and cardiovascular disease. Moreover, IR can occur even non-obese people without diabetes. However, direct detection is complicated. In order to find a simple surrogate marker early people, we investigate association commonly-used biochemical markers (liver enzymes lipid profiles) with urban middle-aged older Chinese Methods This cross-sectional study...