A5100384325- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Pelvic floor disorders treatments
- Drug-Induced Hepatotoxicity and Protection
- Pregnancy-related medical research
- Pharmacological Effects of Natural Compounds
- Organ Transplantation Techniques and Outcomes
- Endoplasmic Reticulum Stress and Disease
- Macrophage Migration Inhibitory Factor
- Hepatitis B Virus Studies
- Pelvic and Acetabular Injuries
- Pediatric Hepatobiliary Diseases and Treatments
- Anorectal Disease Treatments and Outcomes
- Protease and Inhibitor Mechanisms
- Intensive Care Unit Cognitive Disorders
- Proteoglycans and glycosaminoglycans research
- Animal Virus Infections Studies
- Hepatitis C virus research
- Anesthesia and Neurotoxicity Research
- Autophagy in Disease and Therapy
- Acupuncture Treatment Research Studies
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Fibroblast Growth Factor Research
Shanghai University of Traditional Chinese Medicine
2015-2025
Tongji Hospital
2012-2023
Huazhong University of Science and Technology
2012-2023
Xinqiao Hospital
2023
Army Medical University
2023
Sun Yat-sen Memorial Hospital
2023
Sun Yat-sen University
2023
Wuhan University
2015-2022
Renmin Hospital of Wuhan University
2015-2022
Nantong Tumor Hospital
2022
Hyaluronan (HA), a major extracellular matrix glycosaminoglycan, is biomarker for cirrhosis. However, little known about the regulatory and downstream mechanisms of HA overproduction in liver fibrosis. Hepatic synthase 2 (HAS2) expression was elevated both human murine production fibrosis were reduced mice lacking HAS2 hepatic stellate cells (HSCs), whereas overexpressing had exacerbated transcriptionally up-regulated by transforming growth factor-β through Wilms tumor 1 to promote...
TLR4 signaling induces down-regulation of the bone morphogenic protein (BMP) and activin membrane-bound inhibitor (BAMBI), which enhances TGF-β during hepatic stellate cell (HSC) activation. We investigated mechanism by down-regulates BAMBI expression in HSCs found that TLR4- TNF-α-mediated is dependent on regulation promoter activity through interaction with NF-κBp50 HDAC1 HSCs. Bambi was predominantly expressed HSCs, at high levels quiescent but low vivo-activated LPS-stimulated In human...
Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) plays a central role in the pathogenesis of diabetes. This protein has been recognized as potential target for diabetic therapy. In this study, we identified astragaloside IV (AS-IV) potent modulator SERCA inhibiting renal injury status. Increasing doses AS-IV (2, 6, and 18 mg kg-1 day-1) were administered intragastrically to db/db mice 8 weeks. Biochemical histopathological approaches conducted evaluate therapeutic effects AS-IV. Cultured...
Abstract Electrical stimulation (ES) therapy has good effects in patients with nervous system injury-related diseases. ES promotes nerve cell regeneration and stimulates Schwann cells to express neurotrophic factors. The incidence of stress urinary incontinence (SUI) among elderly people is increasing. Some studies suggest that damage the pudendal closely related pathogenesis SUI. It also been found pelvic can reduce SUI symptoms a rat model caused by injury. Clinically, floor electrical...
Pelvic organ prolapse (POP) is a global health problem, for which the pathophysiological mechanism remains to be fully elucidated. The loss of extracellular matrix protein has been considered most important molecular basis facilitating development POP. Oxidative stress (OS) well‑recognized involved in fiber metabolic disorders. present study aimed clarify whether OS exists uterosacral ligament (USL) with POP, and investigate precise role collagen metabolism human USL fibroblasts (hUSLFs). In...
Surgical trauma can induce an inflammatory response in the central nervous system. Neuroinflammation is a crucial pathological mechanism of perioperative neurocognitive disorders (PND). Dexmedetomidine (Dex) alpha (α)-2 adrenoceptor agonist that widely used period. Previous studies have shown Dex has neuroprotection various nerve injury models, but its role PND remains unclear. Our study aimed to observe neuroprotective effect pretreatment on postoperative cognitive change and explore...
Objective Although glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor-β superfamily, its function in liver fibrosis has rarely been studied. Here, we investigated role GDNF hepatic stellate (HSC) activation and humans mice. Design expression was examined biopsies sera from patients with fibrosis. The functional mice adenoviral delivery gene, sgRNA CRISPR/Cas9 administration GDNF-blocking antibodies. on HSC using human mouse primary HSCs. binding...
Gastric cancer (GC) is the most prevalent in Asia. Shikonin, one of ingredients extracted from roots Lithospermum erythrorhizon, has been proven to be a necrosis inducer and an antitumour effect on many cancers. We explored mechanism shikonin GC. CCK8 clonogenic assays were used determine proliferation GC cell lines. Shikonin could induce reactive oxygen species (ROS), lipid ROS, intracellular ferrous iron (Fe2+), malondialdehyde (MDA) also found that decreased expression GPX4 by suppressing...
The aim of the present study was to explore underlying mechanisms roles mechanical factors in pathogenesis pelvic organ prolapse (POP). experiments were performed on fibroblasts derived from uterosacral ligaments and cardinal patients who received total hysterectomy due benign disease excluding POP. Fibroblasts cultured after collagenase digestion identified by morphological observation immunocytochemical methods. A four‑point bending device used subject at passage 4‑6 strains 0, 1,333 µ (1...
Severe acute pancreatitis (SAP) is a sudden inflammation of the pancreas. The traditional Chinese medicine formula Dachengqi decoction (DCQD) proven to be beneficial in comprehensive treatment for patients clinical practice. However, molecular mechanism DCQD on SAP remains unclear. High mobility group box 1(HMGB1) that functions as damage-associated pattern molecule (DAMP) has attracted much interest.In this study, we used lipopolysaccharide (LPS) and cerulein induce severe C57BL/6 mice with...
Telomerase activity and telomerase reverse transcriptase (hTERT), the key component of complex, are tightly proliferation regulated in normal malignant cells both vitro vivo; however, underlying mechanisms unclear. In present study, we identified mitogen-activated protein kinase (MAPK) cascade-mediated histone H3 ser10 phosphorylation to be a molecular link between induction hTERT/telomerase activity. human T lymphocytes fibroblasts, growth or stress stimuli known drive through MAPK...
Abstract Background Huangqi decoction was first described in Prescriptions of the Bureau Taiping People's Welfare Pharmacy Song Dynasty (AD 1078), and it is an effective recipe that usually used to treat consumptive disease, anorexia, chronic liver diseases. Transforming growth factor beta 1 (TGFβ1) plays a key role progression fibrosis, its ingredients (IHQD) markedly ameliorated hepatic fibrotic lesions induced by ligation common bile duct (BDL). However, mechanism IHQD on not yet clear....
Macrophages in other organs (e.g. kidneys, lungs, and spleen, et. al) have rarely been reported the development of liver fibrosis. Therefore, it is important to investigate macrophage activation main We investigated potential antifibrogenic effects paeoniflorin (PF) a dimethylnitrosamine (DMN)-induced rat model with special focus on inhibiting organs. Rat hepatic fibrosis was induced by treatment DMN three times weekly over 4-week period. rats were treated water, PF, or gadolinium chloride...
Abstract Background/aims Liver sinusoidal endothelial cells (SECs), hepatic stellate (HSCs) and Kupffer (KCs) are involved in the development of liver fibrosis represent a potential therapeutic target. The effects on sorafenib, multiple tyrosine kinase inhibitor, gadolinium chloride (GdCl3), which depletes KCs, were evaluated rats. Methods was induced rats with dimethylnitrosamine, sorafenib and/or GdCl3 these monitored. Interactions among ECs, HSCs KCs assessed by laser confocal microscopy....
Objective: Intracranial aneurysm (IA) represents a devastating disease with high rates of disability and mortality, which is initiated by dysfunction endothelial cells (ECs).Evidence suggests the dysregulation E3 ubiquitin ligase family during EC injury.In this work, role an ligase, casitas B lymphoma-B (CBL-B), was explored in human brain microvascular (HBMEC) function through NLRP3 pathway.Methods: In vitro IA model induced treating HBMECs oxidized low-density lipoprotein (ox-LDL).The...
Notch signaling has been demonstrated to be involved in ductular reactions and fibrosis. Previous studies have shown that Huang Qi Decoction (HQD) can prevent the progression of cholestatic liver fibrosis (CLF). However, whether HQD affects pathway is unclear. In this study, CLF was established by common bile duct ligation (BDL) rats. At end first week, rats were randomly divided into a model group (i.e., BDL), an group, sorafenib positive control (SORA) treated for 3 weeks. Bile...
Pelvic organ prolapse (POP) is a global health problem that may seriously impact the quality of life sufferer. The present study aimed to investigate potential mechanisms underlying alterations in extracellular matrix (ECM) metabolism pathogenesis POP, by investigating expression ECM components human parametrial ligament fibroblasts (hPLFs) subject various mechanical strain loads. Fibroblasts derived from ligaments were cultured patients with POP and without malignant tumors, who underwent...
Abstract Liver fibrosis occurs during wound healing after repeated liver injury and is characterized by extensive extracellular matrix deposition. We previously identified hyaluronan synthase 2 (HAS2) as a driver of hepatic stellate cell (HSC) activation. Developing strategies to suppress HSC activation key alleviating fibrosis, HAS2 an attractive candidate for intervention. To gain insight into the molecular function HAS2, we investigated its posttranscriptional regulation. found that...