A5108971751- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Cancer-related gene regulation
- Zeolite Catalysis and Synthesis
- IL-33, ST2, and ILC Pathways
- Infection Control in Healthcare
- Atherosclerosis and Cardiovascular Diseases
- Reproductive System and Pregnancy
- Wnt/β-catenin signaling in development and cancer
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Hair Growth and Disorders
- Bioactive Compounds in Plants
- Obstructive Sleep Apnea Research
- Angiogenesis and VEGF in Cancer
- Medical Device Sterilization and Disinfection
- Infection Control and Ventilation
- Skin Protection and Aging
- Antibiotic Use and Resistance
- Urinary Bladder and Prostate Research
- Shoulder and Clavicle Injuries
- Effects of Radiation Exposure
- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
Tianjin Hospital
2024
Daping Hospital
2024
Army Medical University
2024
Hebei General Hospital
2024
Affiliated Hospital of North Sichuan Medical College
2024
Sichuan University of Science and Engineering
2024
Shanghai Medical College of Fudan University
2009-2023
Fudan University Shanghai Cancer Center
2020-2023
Fujian Agriculture and Forestry University
2023
Guangxi University of Chinese Medicine
2021
Prostate cancer (PCa) is the second cause of deaths in men USA. When recurs, early stages can be controlled with hormone ablation therapy to delay rate progression but, over time, overcomes its dependence, becomes highly aggressive and metastasizes. Clinical trials have shown that pomegranate juice (PJ) inhibits PCa progression. We previously PJ components luteolin (L), ellagic acid (E) punicic (P) together inhibit growth hormone-dependent -independent cells their migration chemotaxis...
Abstract Background/aims Liver sinusoidal endothelial cells (SECs), hepatic stellate (HSCs) and Kupffer (KCs) are involved in the development of liver fibrosis represent a potential therapeutic target. The effects on sorafenib, multiple tyrosine kinase inhibitor, gadolinium chloride (GdCl3), which depletes KCs, were evaluated rats. Methods was induced rats with dimethylnitrosamine, sorafenib and/or GdCl3 these monitored. Interactions among ECs, HSCs KCs assessed by laser confocal microscopy....
Wnt signaling is involved in embryo development and cancer. The binding between the DIX domains of Axin1/2, Dishevelled1/2/3, Coiled-coil-DIX1 essential for Wnt/β-catenin signaling. Structural biological studies have revealed that are polymerized through head-to-tail interface interactions, which indispensable activating β-catenin Although different isoforms Dvl Axin proteins display both redundant specific functions signaling, specificity DIX-mediated interactions remains unclear due to...
To explore the regulatory effects of microRNA (miRNA)-224 and its potential target gene, cyclin dependent kinase 9 (CDK9), in pathological process allergic rhinitis (AR).To investigate role miR-224 CDK9, it was screened by bioinformatics prediction software verified dual-luciferase reporter assay. The mouse model AR established ovalbumin (OVA).The animal models were intervened with agomir, negative control saline respectively. symptoms sneezing nasal rubbing recorded. expressions miR224,...
RAD54 homolog B is a central motor protein of homologous recombination (HR), which plays an important role in the development and evolution human cancer. Recent studies have indicated that RAD54B aberrantly expressed variety cancers exhibits numerous biological functions, including participating repair DNA double strand breaks. However, expression function liver cancer not yet been reported. The aim present study was to investigate elucidate its cell lines by inhibiting using...
The prevalence of Obstructive Sleep Apnea (OSA) is high, and there are many complications. Few studies have reported the relationship between OSA kidney stones. purpose this study to explore whether people at risk will increase
Neoadjuvant immunochemotherapy (NAIC) markedly induces pathologic regression in locally advanced gastric adenocarcinoma. However, specific biomarkers are still lacking to effectively identify the beneficiary patients for NAIC.
GCNT4 is a member of the glucosaminyl (N-acetyl) transferases family that has been implicated in multiple human malignancies. However, role gastric cancer (GC) unknown. In this present study, we aimed to explore and clinicopathological correlation GC.We first evaluated dysregulation The Cancer Genome Atlas (TCGA) then performed RT-qPCR immunohistochemistry validate results cohort in-house patients. function GC were also analysed.GCNT4 was found be significantly downregulated GC. addition,...
The role and significance of liver-derived cytokines in cancer-associated cachexia syndrome remain elusive. Here we report that combinatorial counterbalances the leptin Igf1 signaling pathways hepatocellular carcinoma (HCC) models significantly relieves cachexia. Double transgenic zebrafish HCC stably displayed focal lesions, anorexia, wasting adipose muscle tissues were first generated. Knockout lepr or mc4r from these partially restored appetite exerted moderate no effect on tissue...
Objective To observe the effect of simvastatin on expression high mobility group box-1 protein (HMGB1) and morphology atherosclerotic plaques in rats, to ascertain whether HMGB1 plays a role preventive mechanism from atherosclerosis (AS). Methods Sixty Wistar rats were divided randomly into three groups: control group, model treatment group. Gastric gavage vitamin D3 with fat food was used reproduce atherosclerotie rat model. The treated 2.5 mg·kg-1· d-1 (gatric perfusion) 8 weeks after...