A5020238644- Bone Tissue Engineering Materials
- Pharmaceutical and Antibiotic Environmental Impacts
- Liver physiology and pathology
- Pluripotent Stem Cells Research
- Meromorphic and Entire Functions
- Graphene and Nanomaterials Applications
- Advanced Differential Equations and Dynamical Systems
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Supercapacitor Materials and Fabrication
- Cancer Immunotherapy and Biomarkers
- Advanced Photocatalysis Techniques
- Pancreatic function and diabetes
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticles: synthesis and applications
- Forest Insect Ecology and Management
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Marine Sponges and Natural Products
- Chronic Lymphocytic Leukemia Research
- Ferroptosis and cancer prognosis
- Composting and Vermicomposting Techniques
- Conducting polymers and applications
- Invertebrate Immune Response Mechanisms
Capital Medical University
2015-2025
Rutgers, The State University of New Jersey
2007-2025
Beijing Tongren Hospital
2023-2025
Cincinnati Children's Hospital Medical Center
2018-2025
West China Medical Center of Sichuan University
2025
Linyi University
2023-2025
WuXi AppTec (China)
2023-2025
Hebei North University
2024-2025
Environmental and Occupational Health Sciences Institute
2021-2025
Qingdao University
2019-2024
Modern life sciences research increasingly relies on computational solutions, from large scale data analyses to theoretical modeling. Within the models Boolean networks occupy an increasing role as they are eminently suited at mapping biological observations and hypotheses into a mathematical formalism. The conceptual underpinnings of modeling very accessible even without background in quantitative sciences, yet it allows scientists describe explore wide range surprisingly complex phenomena....
Background & AimsPreclinical identification of compounds at risk causing drug induced liver injury (DILI) remains a significant challenge in development, highlighting need for predictive human system to study complicated DILI mechanism and susceptibility individual drug. Here, we established organoid (HLO)–based screening model analyzing pathology resolution.MethodsWe first developed reproducible method generate HLO from storable foregut progenitors pluripotent stem cell (PSC) lines with...
Therapies against hepatitis B virus (HBV) have improved in recent decades; however, the development of individualized treatments has been limited by lack infection models. In this study, we used human induced pluripotent stem cell (hiPSC) to generate a functional liver organoid (LO) that inherited genetic background donor, and evaluated its application modeling HBV exploring virus–host interactions. To establish hiPSC-LO, cultured hiPSC-derived endodermal, mesenchymal, endothelial cells with...
Abstract Great efforts have been devoted so far to combine nano‐magnetic hyperthermia and nano‐photothermal therapy achieve encouraging additive therapeutic performance in vitro vivo with limitation direct intratumoral injection no guidance of multimodality molecular imaging. In this study, a novel multifunctional theranostic nanoplatform (MNP@PES‐Cy7/2‐DG) consisting magnetic nanoparticles (MNPs), poly(3,4‐ethylenedioxythiophene):poly(4‐styrenesulfonate) (PES), Cyanine7 (Cy7),...
There have been many applications in biomedical fields based on hydroxyapatite nanoparticles (HA NPs) over the past decades. However, biocompatibility of HANPs is affected by exposure dose, particle size, and way contact with cells. The objective this study to investigate effect HA NPs different sizes osteogenesis using human mesenchymal stem cells (hMSCs). Three different-sized (~50, ~100, ~150 nm, resp.) were synthesized cytotoxicity, cellular uptake, osteogenic differentiation hMSCs....
Cadmium (Cd) contamination of agricultural soils represents a serious risk to crop safety. A new strategy using abscisic acid (ABA)-generating bacteria, Bacillus subtilis or Azospirillum brasilense, was developed reduce the Cd accumulation in plants grown Cd-contaminated soil. Inoculation with either bacterium resulted pronounced increase ABA level wild-type Arabidopsis Col-0 plants, accompanied by decrease levels plant tissues, which mitigated toxicity. As consequence, growth exposed...
Binge alcohol consumption is a serious health concern. Ferroptosis an iron-dependent lipid peroxidation mediated cell death. Activation of the Kelch-like ECH-associated protein 1 (Keap1)–nuclear factor erythroid 2-related 2 (Nrf2) pathway has been shown to exert protective effect by blunting responses ferroptosis inducers. The autophagy substrate p62 was demonstrated modulate Nrf2 and contribute suppression ferroptosis. Furthermore, inhibition resulted in accumulation p62, which specific for...