A5100341633- Reconstructive Facial Surgery Techniques
- Ear Surgery and Otitis Media
- Spine and Intervertebral Disc Pathology
- Scoliosis diagnosis and treatment
- Osteoarthritis Treatment and Mechanisms
- Liver Disease Diagnosis and Treatment
- Musculoskeletal pain and rehabilitation
- Spinal Fractures and Fixation Techniques
- Reconstructive Surgery and Microvascular Techniques
- Insect symbiosis and bacterial influences
- Lymphoma Diagnosis and Treatment
- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Neuroinflammation and Neurodegeneration Mechanisms
- Spinal Cord Injury Research
- Natural product bioactivities and synthesis
- Mast cells and histamine
- Nematode management and characterization studies
- Influenza Virus Research Studies
- Sulfur Compounds in Biology
- Lung Cancer Treatments and Mutations
- Adipokines, Inflammation, and Metabolic Diseases
- Nerve injury and regeneration
- Autophagy in Disease and Therapy
- Hidradenitis Suppurativa and Treatments
The First Affiliated Hospital, Sun Yat-sen University
2025
Zhongshan Hospital
2022-2025
Fudan University
2025
Sun Yat-sen University
2025
Wenzhou Medical University
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Affiliated Hospital of North Sichuan Medical College
2024-2025
Peking Union Medical College Hospital
2025
Jilin Agricultural Science and Technology University
2022
Shaanxi Provincial People's Hospital
2022
The combination of photosensitizers (PSs) and nanomaterials is a widely used strategy to enhance PS efficacy broaden their applicability. However, the current nanocarrier-based delivery strategies focus on conventional PSs, neglecting critical issue phototoxicity. In this study, DHUOCl-25, an activatable (aPS) activated by hypochlorous acid, synthesized combining silicon source structure activation unit. DHUOCl-25 functions as silica for synthesizing mesoporous nanostrctures (MSNs) using...
The view that parasites can develop cooperative symbiotic relationships with their hosts is both appealing and widely held; however, there no molecular genetic evidence of such a transition. Here we demonstrate mutualistic bacterial endosymbiont grain weevils maintains expresses inv / spa genes encoding type III secretion system homologous to used for invasion by pathogens. Phylogenetic analyses indicate were present in presymbiotic ancestors the weevil endosymbionts, occurring at least 50...
The pathophysiology of spinal cord injury (SCI) involves primary and secondary injury. For the irreversibility injury, therapies SCI mainly focus on whereas inflammation is considered to be a major target for injury; however regulation in unclear targeted are still lacking. In this study, we found that expression BRD4 was correlated with pro-inflammatory cytokines after rats; vitro study microglia showed inhibition either by lentivirus or JQ1 may both suppress MAPK NF-κB signalling pathways,...
Many obligate intracellular pathogens and symbionts undergo genome degeneration during long-term association with eukaryotic hosts; however, very little is known about changes that occur in the initial stages of such associations. By focusing on a clade bacteria have recently established symbiotic associations insect hosts, we identified events may contribute to reduction symbiont genomes. Unlike virtually all other bacteria, maize rice weevils each display substantial sequence divergence...
Abstract Inflammation and neuronal apoptosis contribute to the progression of secondary injury after spinal cord (SCI) are targets for SCI therapy; autophagy is reported suppress in cells M2 polarization may attenuate inflammatory response microglia, while both negatively regulated by mTORC1 signalling. We hypothesize that suppression have dual effects on inflammation be a feasible approach therapy. In this study, we evaluate novel inhibitor signalling, Astragaloside IV (AS‐IV), vitro vivo....
Osteoarthritis (OA), a degenerative disorder, is considered to be one of the most common forms arthritis. Limonin (Lim) extracted from lemons and other citrus fruits. has been reported have anti-inflammatory effects, while inflammation major cause OA; thus, we propose that limonin may therapeutic effect on OA. In this study, OA was assessed in chondrocytes vitro IL-1β induced destabilization medial meniscus (DMM) mice vivo. The Nrf2/HO-1/NF-κB signaling pathway evaluated illustrate working...
The study aimed to evaluate the effect of GeLMA/bFGF hydrogel loaded with dental pulp stem cells (DPSCs) on repair and regeneration traumatic optic nerve injury. was photo-cross-linked by LED light. physical-chemical properties cytocompatibility after being squeezed (GeLMA/bFGF-SQ) were evaluated SEM degradation analyses, as well live/dead CCK-8 assays, respectively. axon growth PC12 MAP2 staining. GeLMA/bFGF/DPSCs-SQ injected in situ into lesion site observe number retinal ganglion (RGCs)...
Effect of Aspirin on the Expression Hepatocyte NF-κB and Serum TNF-α in Streptozotocin-Induced Type 2 Diabetic RatsAspirin is a kind anti-inflammatory drug may be used to reverse hyperglycemia, hyperinsulinemia, dyslipidemia by improving insulin resistance.We hypothesized that aspirin improves resistance type diabetes inhibiting hepatic nuclear factor kappa-β (NF-κB) activation serum tumor necrosis factor-α (TNF-α).Adult male Wistar rats were randomly divided into four groups: control,...
Abstract Diabetes (DB) is a risk factor for osteoarthritis progression. High glucose (HG) one of the key pathological features DB and has been demonstrated to induce apoptosis senescence in chondrocytes. Autophagy an endogenous mechanism that can protect cells against senescence. The effects HG on autophagy including chondrocytes have studied; however, results inconsistent. current study aimed elucidate underlying mechanisms, which could be associated with contrasting outcomes. present...
Pulp regeneration with bioactive dentin-pulp complex has been a research hotspot in recent years. Stem cell therapy provided an interest strategy to regenerate the dental-pulp complex. Hence, this study aimed evaluate effects of photosensitive gelatin methacrylate (GelMA) hydrogel encapsulating dental pulp stem cells (DPSCs) and silver nanoparticles (AgNPs) for vitro. First, AgNPs@GelMA hydrogels were prepared by lithium phenyl-2,4,6-trimethyl-benzoyl phosphinate (LAP) initiation via...
Abstract Oxidative stress has been reported to be closely associated with the development of intervertebral disc degeneration (IDD). IDD is one major causes low back pain. Genistein (GES), main isoflavones soybean, shown exert multiple biological functions on different diseases. Here, we tested therapeutic potential GES for IDD. In vitro experiments, confirmed was nontoxic rat nucleus pulposus cells (NPCs) within concentration 100 μM. Furthermore, able suppress apoptosis in tert‐butyl...
Abstract The inflammatory environment and excessive chondrocyte apoptosis have been demonstrated to play crucial roles in the onset of osteoarthritis (OA). Hydrogen sulfide (H 2 S), a gaseous signalling molecule, exerts an inhibitory effect on inflammation several degenerative diseases. However, protective H S against OA has not fully clarified, its underlying mechanism should be examined further. In current study, role endogenous pathogenesis effects interleukin (IL)‐1β‐induced chondrocytes...
IL-1β promotes inflammatory response and extracellular matrix (ECM) degradation through NF-κB signaling pathway; while cardamonin attenuates the ECM by suppressing pathway<italic>via</italic>Nrf2/HO-1 axis.
Abstract Previous research has produced inconsistent findings concerning the connection between metabolic syndrome and prostate cancer. It is challenging for observational studies to establish a conclusive causal relationship two. However, Mendelian randomization can provide stronger evidence of causality in this context. To examine link composite its components with cancer, we performed two-sample (MR) study utilizing aggregated data from genome-wide association studies, followed by...
To analyse the homogeneous and heterogeneous risk factors for occurrence prognosis in lung cancer patients diagnosed with bone metastasis (BM) by using Surveillance, Epidemiology, End Results (SEER) database.The medical records of or without were identified SEER database between 2010 2015. A multivariate logistic regression analysis was performed to identify factors, a Cox used determine prognostic effects every variable on survival.In total, 34,585 eligible from included analysis. Male...
To prospectively evaluate the effect of local wound infiltration with ropivacaine on postoperative pain relief and stress response reduction after open hepatectomy.A total 56 patients undergoing hepatectomy were randomly divided into two groups: a group (wound solution) control (infiltration isotonic saline solution). A visual analog scale (VAS) at rest movement was used to measure for first 48 h surgery. Mean arterial pressure (MAP), heart rate (HR), time bowel recovery, length...