A5100640071- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Hepatitis B Virus Studies
- Cancer, Hypoxia, and Metabolism
- Traditional Chinese Medicine Studies
- RNA modifications and cancer
- Liver physiology and pathology
- Hepatitis C virus research
- Gastric Cancer Management and Outcomes
- Pharmacological Effects of Natural Compounds
- Long-Term Effects of COVID-19
- Drug-Induced Hepatotoxicity and Protection
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Underwater Vehicles and Communication Systems
- Metastasis and carcinoma case studies
- Ubiquitin and proteasome pathways
- Tryptophan and brain disorders
- HIV/AIDS drug development and treatment
- Pancreatic and Hepatic Oncology Research
- Mechanical Circulatory Support Devices
- Advanced Chemical Sensor Technologies
Nanjing Medical University
2023-2025
Jiangsu Province Hospital
2023-2025
Wuhan University of Science and Technology
2022-2024
Shenzhen Institute of Information Technology
2023
Harbin Institute of Technology
2023
Guangzhou Experimental Station
2023
China University of Geosciences (Beijing)
2023
Shanghai Public Health Clinical Center
2012-2022
First Affiliated Hospital of GuangXi Medical University
2008-2021
Guangxi Medical University
2006-2021
Rationale: The coronavirus disease (COVID-19) pandemic is now a global health concern.Objectives: We compared the clinical characteristics, laboratory examinations, computed tomography images, and treatments of patients with COVID-19 from three different cities in China.Methods: A total 476 were recruited January 1, 2020, to February 15, at hospitals Wuhan, Shanghai, Anhui. divided into four groups according age (moderate, severe, critical) fifth edition Guidelines on Diagnosis Treatment...
Pneumonia associated with the 2019 novel coronavirus (2019-nCoV) is continuously and rapidly circulating at present. No effective antiviral treatment has been verified thus far. We report here clinical characteristics therapeutic procedure for four patients mild or severe 2019-nCoV pneumonia admitted to Shanghai Public Health Clinical Center. All were given including lopinavir/ritonavir (Kaletra®), arbidol, Shufeng Jiedu Capsule (SFJDC, a traditional Chinese medicine) other necessary support...
ABSTRACT Background Since mid-December 2019, a cluster of pneumonia-like diseases caused by novel coronavirus, now designated COVID-19 the WHO, emerged in Wuhan city and rapidly spread throughout China. Here we identify clinical characteristics cohort patients Shanghai. Methods Cases were confirmed real-time RT-PCR analysed for demographic, clinical, laboratory radiological features. Results Of 198 patients, median duration from disease onset to hospital admission was 4 days. The mean age...
Severe cases of coronavirus disease 2019 (COVID-19) cannot be adequately managed with mechanical ventilation alone. The role and outcome extracorporeal membrane oxygenation (ECMO) in the management COVID-19 is currently unclear. Eight patients have received ECMO support Shanghai seven venovenous (VV) one veno arterial (VA) during cardiopulmonary resuscitation. As March 25, 2020, four died (50% mortality), three (37.5%) were successfully weaned off after 22, 40, 47 days support, respectively,...
Background: Heat shock proteins (HSPs) are overexpressed in human hepatocellular carcinoma (HCC) tissue and correlate with aggressiveness prognosis of HCC.Methods: Using the GSE14520 microarray expression profile from Gene Expression Omnibus, we compared HSP gene between tumour non-tumour tissues correlated this outcomes HCC patients.Results: We analysed 220 hepatitis B virus (HBV)-related patients 25 HSPs study.With exception HSPA4L, HSPA12A HSPB8, members family, including HSPH1, HSPBP1,...
Objective: This study aimed to investigate the potential parameters associated with imaging progression on chest CT from coronavirus disease 19 (COVID-19) patients.Results: The average age of 273 COVID-19 patients enrolled were older than those without (p = 0.006). white blood cells, platelets, neutrophils and acid glycoprotein all decreased in (all p < 0.05), monocytes increased 0.025). including homocysteine, urea, creatinine serum cystatin C significantly higher while eGFR 0.001)....
Shufeng Jiedu capsules (SFJDC), a patented herbal drug composed of eight medicinal plants, is used for the treatment different viral respiratory tract infectious diseases. Based on its antiviral, anti-inflammatory and immunoregulatory activity in acute lung injury, SFJDC might be promising candidate COVID-19. To evaluate antiviral properties to discover mechanism action as potential Furthermore, study should determine clinical effectiveness We analyzed effects HCoV-229E mouse model index,...
Omicron variant of SARS-CoV-2 has become the predominant worldwide. VV116 is an oral drug with robust anti-SARS-CoV-2 efficacy in preclinical studies. We conducted open, prospective cohort study to evaluate its safety and effectiveness Chinese participants infected omicron from March 8th, 2022 24th, 2022. 136 hospitalized nonsevere patients confirmed COVID-19 were enrolled including 60 who received (300 mg, BID×5 days) treatment group 76 didn't receive control besides standard treatment....
Objective . This study aimed to evaluate the relationships between long noncoding RNAs (lncRNAs) in tumor tissues and hepatocellular carcinoma (HCC) aggressiveness survival. Methods We correlated lncRNAs with HCC survival clinicopathological features based on Gene Expression Omnibus expression profile GSE36376. Results Eight 240 patients were included. Cox regression analysis indicated that HULC was a positive factor for overall (HR = 0.885, 95% CI 0.797–0.983, and<mml:math...
// Zongguo Yang 1 , Jianliang Zhang Yunfei Lu Qingnian Xu Bozong Tang Qiang Wang Wensi Shishi Chen Lingqing Xiaorong Shanghai Public Health Clinical Center, Fudan University, 201508, China Correspondence to: Chen, e-mail: xiaorong3chen@163.com Yang, dr_yangzg@aliyun.com Keywords: lymphocyte cell, aspartate aminotransferase-lymphocyte ratio index, systemic immune-inflammation survival, hepatocellular carcinoma Received: August 03, 2015 Accepted: September 16, Published: October ABSTRACT It...
•Clinical features of child clusters infected with 2019-nCoV lack a typical pattern.•In mildly children, initial CT may be only negative or subtly abnormal.•Ground-glass opacity and patchy shadow are vital features. AIMTo identify summarise the common findings from 2019 novel coronavirus (2019-nCoV) infections in children.MATERIALS AND METHODSThe clinical characteristics radiological (chest radiography chest computed tomography [CT]) nine children were reviewed this retrospective case...
The gut microbiota system plays a vital role in liver diseases. This study aimed to address the diversity of and its correlations with clinical parameters healthy individuals, chronic disease (CLD), hepatocellular carcinoma (HCC) patients. Fecal specimens nine 11 CLD, 21 HCC were collected. was examined by PCR Illumina MiSeq sequencing analyzed using 16S rRNA gene database. between participants also addressed. Compared Firmicutes at phylum level decreased CLD patients Proteobacteria...
Cancer-associated fibroblasts (CAFs), known for facilitating the progression and metastasis of colorectal cancer (CRC), have become a promising therapeutic target. However, significant heterogeneity CAFs their intricate crosstalk with tumor cells present substantial challenges in development precise effective strategies. Single-cell RNA sequencing (scRNA-seq) technology was used to identify various cell subtypes. Spatial transcriptomics (ST) employed map spatial niches colocalization...
A near-real-time version of the blended sea surface wind (BSSW) data product from multiple satellites, as well processing method, and accuracy analysis is introduced in this paper. The BSSW used winds provided by virtual satellite constellation composed HY-2 series Metop satellites DMSP input. Error analysis, cross-calibration 2D-Var applied to blend these derived different platform. With methods, a with 6 hours interval spatial resolution 25 kilometers produced released operationally...
This study is aimed at investigating the predictive value of CENPA in hepatocellular carcinoma (HCC) development.Using integrated bioinformatic analysis, we evaluated mRNA expression tumor and adjacent tissues correlated it with HCC survival clinicopathological features. A Cox regression hazard model was also performed.CENPA significantly upregulated compared that tissues, which were validated The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) series (all P < 0.01). In Kaplan-Meier...
Abstract Background The course of disease in mild and moderate COVID-19 has many implications for mobile patients, such as the risk spread infection, precautions taken, investigations targeted at preventing transmission. Methods Three hundred thirty-one adults were hospitalized from January 21 to February 22, 2020, classified severe (10%) or critical (4.8%) cases; 1.5% died. Two eighty-two (85.2%) cases admitted regular wards. Epidemiological, demographic, clinical, chest computed tomography...
Abstract Background Long-term accumulation of misfolded proteins leads to endoplasmic reticulum (ER) stress in colorectal cancer (CRC). However, the precise pathways controlling decision between survival and apoptosis CRC are unclear. Therefore, this study, we investigated function molecular mechanism glucosidase I (GCS1) regulating ER CRC. Methods A public database was used confirm expression level GCS1 normal tissues. Clinical samples from our center were mRNA protein levels GCS1. Cell...
Tamoxifen and anastrozole are widely used as adjuvant treatment for early stage breast cancer, but their hepatotoxicity is not fully defined. We aimed to compare of with tamoxifen in the setting postmenopausal cancer patients. Three hundred fifty-three Chinese women hormone receptor-positive were randomized or after optimal primary therapy. The end-point was fatty liver disease, defined a liver-spleen ratio <0.9 determined using computed tomography scan. secondary end-points included...
Overexpression of AKR1B10 correlated with tumorigenesis many human malignancies; however, the prognostic value expression in patients hepatocellular carcinoma (HCC) still remains controversial. In this analysis, HCC tumors were evaluated GEO, TCGA and Oncomine databases, a survival analysis based on profile was performed. We found that significantly overexpressed compared nontumors 7 GEO series (GSE14520, GSE25097, GSE33006, GSE45436, GSE55092, GSE60502, GSE77314) (all P < 0.05)....