A5089628148- 3D Surveying and Cultural Heritage
- Gut microbiota and health
- Bacteriophages and microbial interactions
- Optical measurement and interference techniques
- Machine Learning in Bioinformatics
- Genomics and Phylogenetic Studies
- Asthma and respiratory diseases
- Pneumonia and Respiratory Infections
- Respiratory and Cough-Related Research
- Computational Drug Discovery Methods
- Clostridium difficile and Clostridium perfringens research
- Industrial Vision Systems and Defect Detection
- Reproductive System and Pregnancy
- Systemic Sclerosis and Related Diseases
- Pharmacovigilance and Adverse Drug Reactions
- Bioinformatics and Genomic Networks
- Human Pose and Action Recognition
- Face recognition and analysis
- Multiple Sclerosis Research Studies
- Music Therapy and Health
- Long-Term Effects of COVID-19
- 3D Shape Modeling and Analysis
- Systemic Lupus Erythematosus Research
- Bayesian Methods and Mixture Models
- Immune Response and Inflammation
Central China Normal University
2021-2024
Shanghai University of Traditional Chinese Medicine
2017-2023
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2017-2023
Dalian Medical University
2021
HEC Pharm (China)
2021
Qingdao University
2021
Biogen (United States)
2018
Xi'an Jiaotong University
2010
ABSTRACT Background Since mid-December 2019, a cluster of pneumonia-like diseases caused by novel coronavirus, now designated COVID-19 the WHO, emerged in Wuhan city and rapidly spread throughout China. Here we identify clinical characteristics cohort patients Shanghai. Methods Cases were confirmed real-time RT-PCR analysed for demographic, clinical, laboratory radiological features. Results Of 198 patients, median duration from disease onset to hospital admission was 4 days. The mean age...
Controllable 3D scene generation has extensive applications in virtual reality and interior design, where the generated scenes should exhibit high levels of realism controllability terms geometry. Scene graphs provide a suitable data representation that facilitates these applications. However, current graph-based methods for are constrained to text-based inputs insufficient adaptability flexible user inputs, hindering ability precisely control object To address this issue, we propose...
Controllable 3D scene generation has extensive applications in virtual reality and interior design, where the generated scenes should exhibit high levels of realism controllability terms geometry. Scene graphs provide a suitable data representation that facilitates these applications. However, current graph-based methods for are constrained to text-based inputs insufficient adaptability flexible user inputs, hindering ability precisely control object To address this issue, we propose...
Subcutaneous (SC) peginterferon beta-1a and SC interferon (IFN beta-1a) have demonstrated efficacy in treating relapsing-remitting multiple sclerosis (RRMS) but never been compared direct head-to-head clinical trials, the gold-standard comparison. A well-balanced matching-adjusted comparison of weighted individual patient data on beta-1a, aggregate from published phase 3 trials IFN was conducted to provide additional information comparative these two agents.Individual a study 125 mcg every...
Detecting side effects of drugs is a fundamental task in drug development. With the expansion publicly available biomedical data, researchers have proposed many computational methods for predicting drug-side effect associations (DSAs), among which network-based attract wide attention field. However, problem data scarcity poses great challenge existing DSAs prediction models. Although several augmentation been to address this issue, most employ random way manipulate original networks, ignores...
Due to the abuse of antibiotics, some pathogenic bacteria have developed resistance most leading emergence antibiotic-resistant superbugs. Therefore, researchers resort phage therapy for bacterial infections. For therapy, fundamental step is accurately identify phage-host interactions. Although various methods been proposed, existing suffer from following two shortcomings: 1) they fail make full use genetic information including both genome and protein sequence phages; 2) host specificity...
Identifying phage-host interactions (PHIs) is a crucial step in developing phage therapy, which the promising solution to addressing issue of antibiotic resistance superbugs. However, lifestyle phages, strongly depends on their host for life activities, limits cultivability, making study predicting PHIs time-consuming and labor-intensive traditional wet lab experiments. Although many deep learning (DL) approaches have been applied prediction, most DL methods are predominantly based sequence...
Abstract Bacterial resistance has emerged as one of the greatest threats to human health, and phages have shown tremendous potential in addressing issue drug-resistant bacteria by lysing host. The identification phage–host interactions (PHI) is crucial for bacterial infections. Some existing computational methods predicting PHI are suboptimal terms prediction efficiency due limited types available information. Despite emergence some supporting information, generalizability models using this...
To solve the problem of measurement for welding deformation sheet metal, a non-contact three-dimension optical method is proposed. Firstly, photos moving objects from different observation points are taken by two high-resolution and high-speed digital cameras simultaneously. Secondly, three-dimensional coordinates targets calculated reconstruction technique including collinear equation, photo orientation based on coplanar direct linear transform, epipolar geometric constraint bundle...
Over the past two or three decades, prevalence of asthma has significantly increased worldwide; therefore, effective treatment without side effects is utmost importance. Traditional Chinese medicine (TCM) plays a vital role in reducing symptoms and improving quality life persistent-asthma patients. The aim this study to evaluate efficacy Jia Wei Yang He (JWYH) formula explore relationship between airway microbiome TCM This multicenter, parallel-arm, randomized, double-blinded,...
Computational drug repositioning can identify potential associations between drugs and diseases. This technology has been shown to be effective in accelerating development reducing experimental costs. Although there plenty of research for this task, existing methods are deficient utilizing complex relationships among biological entities, which may not conducive subsequent simulation treatment processes. In article, we propose a heterogeneous graph embedding method called HMLKGAT infer novel...
This paper presents an accurate calibration method of binocular 3D measurement systems for industrial on-site inspection, which uses a cross target with ring coded points. The can be used to calibrate large-scale field-of-view stereo and obtain higher precision conveniently. world coordinates these points are not required. initial value is computed by using the relative orientation Direct Linear Transform (DLT) photogrammetry. bundle adjustment algorithm optimize parameters as well...
Objective: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, and symptom-based diagnosis. Because of the unclear mechanisms, treatment available have not acquired satisfied effect. We performed meta-analysis to assess effectiveness safety herbal enema in treating IBS compared calcium channel blocker administration. Methods: searched for randomized controlled trials (RCTs) testing patients with which administration PubMed, EMMBASE, Chinese National Knowledge...
Single herbs and Chinese patent medicine preparations often have bad taste, such as bitterness astringency, which is one of the key factors affecting patients' medication compliance, would affect therapeutic effect restrict extensive application in clinical practice. Therefore, how to make use taste masking techniques improve traditional medicines has become an important project. Through collection summarization foreign journals papers recent years, this paper discussed generation mechanism...
This paper presents a new data reduction algorithm to reduce redundant in rang image or three dimension point cloud. Firstly, an automatic subdivision program is developed identify the most representative points among points. The employs standard k-means clustering procedure gather similar together spatial domain and uses max normal deviation minimize dissimilarity feature field. Secondly, boundary detection maintain integrity of border, which conducted before program. To avoid final...
Abstract Microbes can affect the metabolism and immunity of human body incessantly, dysbiosis microbiome drives not only occurrence but also progression disease (i.e. multiple statuses disease). Recently, microbiome-based association tests have been widely developed to detect between host phenotype. However, existing methods achieved satisfactory performance in testing ordinal/nominal multicategory phenotypes (e.g. severity tumor subtype). In this paper, we propose an optimal test for...
To solve the problem of deformation measurement for spatial complex tubular joints, a non-contact three-dimension optical method is proposed. Firstly, some artificial targets are pasted on area before loading. Then coordinates those calculated by reconstruction technique including collinear equation, image orientation based coplanar direct linear transform, epipolar geometric constraint and bundle adjustment. Finally, each single stage aligned to basic stage, tracking comparing homonymous...
April 23, 2018April 10, 2018Free AccessEffect of PD medication on disease progression as measured by rate change in MDS_UPDRS PPMI study (P2.042)Zhen Xiao, Jesse Cedarbaum, and Minhua YangAuthors Info & AffiliationsApril 2018 issue90 (15_supplement)https://doi.org/10.1212/WNL.90.15_supplement.P2.042 Letters to the Editor
Abstract Background Qingfei Tongluo formular (QT) is a homemade agent for the Mycoplasma pneumoniae pneumonia (MPP) treatment developed by pediatrics of Shanghai Longhua hospital, which combining with AZM(azithromycin) has better clinical curative effect. This study aims at exploring chemical components and clarifying possible mechanism involved in. Methods LC-MS was used analysis. The mycoplasma infected mice were treated AZM QT (46.25 92.5 mg/g) 3 days. Polymorphonuclear neutrophils (PMNs)...
Abstract Background Chronic cough is one of the most common and frequently-occurring diseases in children. We investigated etiologies clinical features children with chronic (CC), order to improve diagnostic treatment disease by pediatricians. Methods The data 420 cases children, aged 1–14 years old, from 5 hospitals’ Outpatient Department different regions Shanghai, who suffered between period September 2017 July 2019 were prospectively analyzed. Children enrolled identify specific cause...
Abstract Microbes affect the metabolism, immunity, digestion and other aspects of human body incessantly, dysbiosis microbiome drives not only occurrence but also development disease (i.e., multiple statuses disease). Recently, microbiome-based association tests have been widely developed to detect between host phenotype. However, existing methods achieved satisfactory performance in testing ordinal/nominal multicategory phenotypes (e.g., severity tumor subtype). In this paper, we propose an...