A5058691051- Genetic Associations and Epidemiology
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Renin-Angiotensin System Studies
- Liver Disease Diagnosis and Treatment
- Nutrition, Genetics, and Disease
- Multiple Myeloma Research and Treatments
- Renal Transplantation Outcomes and Treatments
- Hormonal Regulation and Hypertension
- Bioinformatics and Genomic Networks
- Organ Transplantation Techniques and Outcomes
- Protein Degradation and Inhibitors
- Renal and Vascular Pathologies
- Reproductive System and Pregnancy
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Renal and related cancers
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Renal cell carcinoma treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pregnancy and preeclampsia studies
- Phytochemical compounds biological activities
- Statistical Methods and Bayesian Inference
- SARS-CoV-2 detection and testing
Shanghai Jiao Tong University
2019-2025
Shanghai Institute of Hematology
2020-2025
University of Manchester
2016-2025
Ruijin Hospital
2019-2025
Xuzhou Medical College
2025
Shenzhen Academy of Inspection and Quarantine
2024
Jilin Medical University
2020-2023
Beijing Chao-Yang Hospital
2023
Capital Medical University
2023
Tibet Autonomous Region People's Hospital
2022-2023
High blood pressure (BP) is a risk factor for cardiovascular morbidity and mortality. While BP regulated by the function of kidney, vasculature, sympathetic nervous system, recent experimental data suggest that immune cells may play role in hypertension.We studied relationship between major white cell types UK Biobank population used Mendelian randomization (MR) analyses using ≈750 000 UK-Biobank/International Consortium Blood Pressure-Genome-Wide Association Studies to examine which...
Abstract Background and aims Observational studies have linked elevated blood pressure (BP) to impaired cognitive function. However, the functional structural changes in brain that mediate relationship between BP elevation impairment remain unknown. Using observational genetic data from large consortia, this study aimed identify structures potentially associated with values Methods results Data on were integrated 3935 magnetic resonance imaging-derived phenotypes (IDPs) function defined by...
Plant microRNAs (miRNAs) are vital components of the translation control system that regulates plant development and reproduction. The biological function sly-miR156 was investigated by over-expression in tomato plants. Transgenic plants exhibited a drastically altered phenotype, with reduced height, smaller but more numerous leaves, fruit. inflorescence structure over-expressing phenocopied sft mutant. putative targets were identified data base search included six SQUAMOSA PROMOTER BINDING...
Abstract Mitochondrial fusion is linked to heart and liver ischemia‐reperfusion (IR) insult. Unfortunately, there no report elucidate the detailed influence of mitochondrial in renal IR injury. This study principally investigated mechanism by which protected kidney against Our results indicated that sirtuin 3 (Sirt3) was inhibited after injury vivo vitro. Overexpression Sirt3 improved function, modulated oxidative injury, repressed inflammatory damage, reduced tubular epithelial cell...
The ongoing pandemic of Coronavirus disease 19 (COVID-19) is caused by a newly discovered β named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). How long the adaptive immunity triggered SARS-CoV-2 can last critical clinical relevance in assessing probability second infection and efficacy vaccination. Here we examined, using ELISA, IgG antibodies serum specimens collected from 17 COVID-19 patients at 6-7 months after diagnosis results were compared to those cases investigated...
Genome-wide association studies (GWAS) have identified >100 loci of chronic kidney disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations remain elusive. Using 280 transcriptomes and 9958 gene expression profiles from 44 non-renal tissues we uncover partners (eGenes) for 88.9% CKD-dt GWAS loci. Through epigenomic chromatin segmentation analysis variant effect prediction annotate functional consequences to 74% Our colocalisation Mendelian randomisation in...
Multiple myeloma is a malignant plasma-cell disease, which highly dependent on the hypoxic bone marrow microenvironment. However, underlying mechanisms of hypoxia contributing to genesis are not fully understood. Here, we show that long non-coding RNA DARS-AS1 in directly upregulated by inducible factor (HIF)-1. Importantly, required for survival and tumorigenesis cells both vitro vivo. exerts its function binding RNA-binding motif protein 39 (RBM39), impedes interaction between RBM39 E3...
Abstract Aims Angiotensin-converting enzyme 2 (ACE2) is the cellular entry point for severe acute respiratory syndrome coronavirus (SARS-CoV-2)—the cause of disease 2019 (COVID-19). However, effect renin-angiotensin system (RAS)-inhibition on ACE2 expression in human tissues key relevance to blood pressure regulation and COVID-19 infection has not previously been reported. Methods results We examined how hypertension, its major metabolic co-phenotypes, antihypertensive medications relate...
Abstract Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-specific epigenomic annotations and 3D genome information we generated validated gene expression prediction models for the purpose transcriptome-wide association studies in 700 human kidneys. We identified 889 kidney genes associated with BP which 399 were prioritised as contributors to regulation. Imputation proteome microRNAome uncovered 97 renal proteins 11 miRNAs BP. Integration plasma...
Objective: The male-specific region of the Y chromosome (MSY) remains one most unexplored regions genome. We sought to examine how genetic variants MSY influence male susceptibility coronary artery disease (CAD) and atherosclerosis. Approach Results: Analysis 129 133 men from UK Biobank revealed that only 7 common haplogroups (haplogroup I1) was associated with CAD—carriers haplogroup I1 had ≈11% increase in risk CAD when compared all other combined (odds ratio, 1.11; 95% CI, 1.04–1.18; P...
Nephrons scar and involute during aging, increasing the risk of chronic kidney disease. Little is known, however, about genetic mechanisms aging. We sought to define signatures age on renal transcriptome using 563 human kidneys. The initial discovery analysis 260 transcriptomes from TRANScriptome renaL humAn TissuE Study (TRANSLATE) Cancer Genome Atlas identified 37 age-associated genes. For 19 those genes, association with was replicated in 303 Nephroseq resource. Surveying 42 nonrenal...
Abstract Background DNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR more common among US Hispanics African Americans. The causes for this are poorly understood. We aimed to identify trans-ethnic ethnic-specific differentially methylated positions (DMPs) using an agnostic, genome-wide approach. Methods study included up 5428 participants from multi-ethnic studies discovery 8109 replication....
Studies on the relationship between renal function and human plasma proteome have identified several potential biomarkers. However, investigations been conducted largely in European populations, causality of associations proteins kidney has never addressed.A cross-sectional study 993 among 2882 participants four studies admixed ancestries (KORA, INTERVAL, HUNT, QMDiab) transethnic eGFR/CKD proteomic For replicated associations, two-sample bidirectional Mendelian randomization (MR) was used...
The pathophysiology of coronavirus disease 19 (COVID-19) involves a multitude host responses, yet how they unfold during the course progression remains unclear. Here, through integrative analysis clinical laboratory tests, targeted proteomes, and transcriptomes 963 patients in Shanghai, we delineate dynamics multiple circulatory factors within first 30 days post-illness onset convalescence. We show that hypercortisolemia represents one probable causes acute lymphocytopenia at severe/critical...
Aberrant alternative splicing is one of the hallmarks cancer and potentially based on upregulated expression factors in some types cancer. Our previous study suggested that factor RBM39 significantly multiple myeloma (MM) its upregulation positively associated with poor prognosis. Here, we further demonstrate survival proliferation MM cells rely knockdown inhibits malignant growth MM. Indisulam, a "molecular glue" mediates proteasomal degradation RBM39, has potent suppressive effects both...
This paper considers novel Bayesian non-parametric methods for stochastic epidemic models. Many standard modeling and data analysis use underlying assumptions (e.g. concerning the rate at which new cases of disease will occur) are rarely challenged or tested in practice. To relax these assumptions, we develop a approach using Gaussian Processes, specifically to estimate infection process. The illustrated with both simulated real sets, former illustrating that can recover true process quite...