Robert Król
A5008391401- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Liver Disease and Transplantation
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Adrenal and Paraganglionic Tumors
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Pituitary Gland Disorders and Treatments
- Lung Cancer Research Studies
- Spine and Intervertebral Disc Pathology
- Genetic and Kidney Cyst Diseases
- Neurological Complications and Syndromes
- Dialysis and Renal Disease Management
- Ovarian cancer diagnosis and treatment
- Transplantation: Methods and Outcomes
- Cancer, Hypoxia, and Metabolism
- Hedgehog Signaling Pathway Studies
- Liver Diseases and Immunity
- Pancreatic function and diabetes
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Neuroblastoma Research and Treatments
Medical University of Silesia
2015-2024
University of Szczecin
2022
University of Silesia in Katowice
2002-2021
Górnośląskie Centrum Medyczne
2003-2004
Silesian Center for Heart Disease
2004
W ostatnim czasie obserwuje się większe zainteresowanie rzadkimi nowotworami neuroendokrynnymi żołądkowo-jelitowo-trzustkowymi (GEP NEN). Wykrywalność nowotworów neuroendokrynnych w ostatnich latach wzrosła. Ponad 50% GEP NEN stanowią rakowiaki, które najczęściej są znajdowane przypadkowo podczas zabiegu operacyjnego jelicie cienkim i wyrostku robaczkowym oraz momencie rozpoznania przerzutów odległych, głównie do wątroby. Istnieje konieczność współdziałania specjalistów różnych dziedzin...
Abstract Aims Angiotensin-converting enzyme 2 (ACE2) is the cellular entry point for severe acute respiratory syndrome coronavirus (SARS-CoV-2)—the cause of disease 2019 (COVID-19). However, effect renin-angiotensin system (RAS)-inhibition on ACE2 expression in human tissues key relevance to blood pressure regulation and COVID-19 infection has not previously been reported. Methods results We examined how hypertension, its major metabolic co-phenotypes, antihypertensive medications relate...
Abstract Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-specific epigenomic annotations and 3D genome information we generated validated gene expression prediction models for the purpose transcriptome-wide association studies in 700 human kidneys. We identified 889 kidney genes associated with BP which 399 were prioritised as contributors to regulation. Imputation proteome microRNAome uncovered 97 renal proteins 11 miRNAs BP. Integration plasma...
Progress in the diagnostics and therapy of gastro-entero-pancreatic (GEP) neuroendocrine neoplasms (NEN), published results new randomised clinical trials, guidelines issued by European Neuroendocrine Tumour Society (ENETS) have led Polish Network Tumours to update 2013 regarding management these neoplasms. We present general recommendations for NENs, developed experts during Third Round Table Conference - Diagnostics neoplasms: view current recommenda-tions, which took place December 2016...
The aim of the study was to analyze gene expression profile pancreatic cancer derive novel molecular markers this malignancy. snap-frozen or RNA-later preserved samples 18 adenocarcinomas, 5 chronic pancreatitis cases and 6 specimens grossly normal pancreas were used for microarray analysis by HG-U133 Plus 2.0 oligonucleotide Affymetrix arrays. Validation carried out real-time quantitative PCR (Q-PCR) in set 66 samples: 31 cancer, 14 21 macroscopically unchanged pancreas. By Principal...
Polish recommendations regarding management of patients suffering from neuroendocrine tumors small intestine and appendix are presented. Small intestine, especially ileum represent most common origin these tumors. Majority them well differentiated grow slowly. Rarely, they less with fast growth poor prognosis. Symptoms atypical, diagnosis could be often accidental. In 4-10% typical symptoms carcinoid syndrome present. Chromogranin A is useful in the laboratory diagnostics, urinary excretion...
Abstract In our transplant center, infection with SARS‐CoV‐2 virus was confirmed in 4 organ recipients (3 kidney and 1 liver recipients) during their early post‐transplant hospital stay. this paper, we report the basic characteristics, management, clinical course, outcomes of these patients.
W niniejszej pracy przedstawiono uaktualnione zalecenia grupy ekspertów Polskiej Sieci Guzów Neuroendokrynnych dotyczące zasad postępowania w nowotworach neuroendokrynnych żołądka i dwunastnicy z uwzględnieniem gastrinoma . Omówiono epidemiologię, patogenezę obraz kliniczny tych nowotworów. Przedstawiono diagnostycznego, uwzględnieniem diagnostyki biochemicznej, histopatologicznej oraz lokalizacyjnej. także zasady terapeutycznego, tym leczenie endoskopowe chirurgiczne, omówiono możliwości...
Neuroendocrine neoplasms/tumours (NENs/NETs) of the large intestine are detected increasingly often, especially rectal tumours, which is probably associated with widespread use screening colonoscopy. There a growing body evidence supporting thesis that NENs rectum and colon two different diseases. Rectal usually small lesions, low to moderate histological malignancy, good prognosis, most may be treated endoscopically. colon, however, often aggressive, poorly differentiated, poor or...
Biliary cancer, comprising cholangio- and gallbladder carcinomas, is associated with high mortality due to asymptomatic disease onset resulting late diagnosis. Currently, no robust diagnostic biomarker clinically available. Therefore, we explored the feasibility of extracellular vesicles (EVs) as a liquid biopsy tool for biliary cancer screening hepatobiliary differentiation.Serum EVs hepatocellular carcinoma, colorectal non-small cell lung patients, well from healthy individuals, were...
We present revised diagnostic and therapeutic guidelines for the management of pancreatic neuroendocrine neoplasms (PNENs) proposed by Polish Network Neuroendocrine Tumours.These refer to biochemical (determination specific nonspecific markers) imaging diagnostics (EUS, CT, MR, radioisotope examination with a 68Ga or 99Tc labelled somatostatin analogue).A histopathological diagnostic, which determines further patients PNENs, must be necessarily confirmed immunohistochemical tests. PNENs...
W pracy przedstawiono uaktualnione polskie zalecenia postępowania z chorymi na nowotwory neuroendokrynne (NEN) jelita cienkiego i wyrostka robaczkowego. Jelito cienkie, a w szczególności jelito kręte, należą do najczęstszych lokalizacji tych nowotworów. Większość nich to wysokozróżnicowane wolno rosnące; rzadko są raki neuroendokrynne. Ich objawy mogą być nietypowe, rozpoznanie opóźnione albo przypadkowe. Zapalenie robaczkowego jest najczęściej pierwszą manifestacją NEN o tym...
W niniejszej publikacji przedstawiono zaktualizowane zalecenia dotyczące diagnostyczno-terapeutycznego postępowania w nowotworach neuroendokrynnych trzustki (PNEN) zaproponowane przez Polską Sieć Guzów Neuroendokrynnych. Zawierają one nowe dane uzyskane latach 2013–2016, które albo potwierdziły wcześniejsze wytyczne, doprowadziły do zmian lub utworzenia dodatkowych zaleceń. diagnostyce duże znaczenie mają badania biochemiczne, obrazowe (anatomiczne i czynnościowe), jak również rozpoznanie...
BACKGROUND Pre-procurement pancreas suitability score (P-PASS) and donor risk (PDRI) index are scoring systems believed to predict of pancreatic grafts. Most European countries the United States apply PDRI, while Poltransplant keeps using P-PASS: more than 16 points raises a red flag for graft use. Recent data discourage use PDRI survival. The aim present study was assess P-PASS as predictors transplanted survival in Polish population. MATERIAL AND METHODS From February 1998 September 2015,...
Background The nerve root sedimentation sign is a magnetic resonance (MR) sign, shown to be present in central lumbar spinal stenosis. lack of the roots dorsal part dural sac consistent with positive sign. Purpose To validate reliability diagnosis different grades canal Material and Methods This study was retrospective review 101 consecutive MR imaging (MRI) studies obtained on patients clinically suspected Based minimum anteroposterior (AP) diameter sample classified into two groups: group...