Violetta Rosiek
A5022666200- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Neuroblastoma Research and Treatments
- Pituitary Gland Disorders and Treatments
- Peptidase Inhibition and Analysis
- Growth Hormone and Insulin-like Growth Factors
- Medical Imaging and Pathology Studies
- Parathyroid Disorders and Treatments
- Hedgehog Signaling Pathway Studies
- Neurofibromatosis and Schwannoma Cases
- Cerebrovascular and genetic disorders
- Intraperitoneal and Appendiceal Malignancies
- Congenital Diaphragmatic Hernia Studies
- Ovarian cancer diagnosis and treatment
- Meningioma and schwannoma management
- Angiogenesis and VEGF in Cancer
- Healthcare during COVID-19 Pandemic
- Gestational Trophoblastic Disease Studies
- Metastasis and carcinoma case studies
- Gyrotron and Vacuum Electronics Research
- Glycogen Storage Diseases and Myoclonus
- TGF-β signaling in diseases
- Metabolism, Diabetes, and Cancer
- Gastrointestinal Tumor Research and Treatment
Medical University of Silesia
2012-2024
W ostatnim czasie obserwuje się większe zainteresowanie rzadkimi nowotworami neuroendokrynnymi żołądkowo-jelitowo-trzustkowymi (GEP NEN). Wykrywalność nowotworów neuroendokrynnych w ostatnich latach wzrosła. Ponad 50% GEP NEN stanowią rakowiaki, które najczęściej są znajdowane przypadkowo podczas zabiegu operacyjnego jelicie cienkim i wyrostku robaczkowym oraz momencie rozpoznania przerzutów odległych, głównie do wątroby. Istnieje konieczność współdziałania specjalistów różnych dziedzin...
Continuous progress in the diagnostics and treatment of neuroendocrine neoplasms (NENs), emerging results new clinical trials, guidelines issued by medical societies have prompted experts from Polish Network Neuroendocrine Tumours to update 2017 recommendations regarding management neoplasms. This article presents general for NENs, resulting findings participating Fourth Round Table Conference, entitled "Polish Guidelines Diagnostics Treatment Neoplasms gastrointestinal tract, Żelechów, June...
Progress in the diagnostics and therapy of gastro-entero-pancreatic (GEP) neuroendocrine neoplasms (NEN), published results new randomised clinical trials, guidelines issued by European Neuroendocrine Tumour Society (ENETS) have led Polish Network Tumours to update 2013 regarding management these neoplasms. We present general recommendations for NENs, developed experts during Third Round Table Conference - Diagnostics neoplasms: view current recommenda-tions, which took place December 2016...
Polish recommendations regarding management of patients suffering from neuroendocrine tumors small intestine and appendix are presented. Small intestine, especially ileum represent most common origin these tumors. Majority them well differentiated grow slowly. Rarely, they less with fast growth poor prognosis. Symptoms atypical, diagnosis could be often accidental. In 4-10% typical symptoms carcinoid syndrome present. Chromogranin A is useful in the laboratory diagnostics, urinary excretion...
In this paper, we present the current guidelines for diagnostics and management of pancreatic neuroendocrine neoplasms (PanNENs) developed by Polish experts providing care these patients in everyday clinical practice. oncological diagnostics, addition to biochemical tests, molecular identification with use NETest liquid biopsy circulating microRNAs is gaining importance. Both anatomical functional examinations (including new radiopharmaceuticals) are used imaging diagnostics....
W niniejszej pracy przedstawiono uaktualnione zalecenia grupy ekspertów Polskiej Sieci Guzów Neuroendokrynnych dotyczące zasad postępowania w nowotworach neuroendokrynnych żołądka i dwunastnicy z uwzględnieniem gastrinoma . Omówiono epidemiologię, patogenezę obraz kliniczny tych nowotworów. Przedstawiono diagnostycznego, uwzględnieniem diagnostyki biochemicznej, histopatologicznej oraz lokalizacyjnej. także zasady terapeutycznego, tym leczenie endoskopowe chirurgiczne, omówiono możliwości...
Neuroendocrine neoplasms/tumours (NENs/NETs) of the large intestine are detected increasingly often, especially rectal tumours, which is probably associated with widespread use screening colonoscopy. There a growing body evidence supporting thesis that NENs rectum and colon two different diseases. Rectal usually small lesions, low to moderate histological malignancy, good prognosis, most may be treated endoscopically. colon, however, often aggressive, poorly differentiated, poor or...
We present revised diagnostic and therapeutic guidelines for the management of pancreatic neuroendocrine neoplasms (PNENs) proposed by Polish Network Neuroendocrine Tumours.These refer to biochemical (determination specific nonspecific markers) imaging diagnostics (EUS, CT, MR, radioisotope examination with a 68Ga or 99Tc labelled somatostatin analogue).A histopathological diagnostic, which determines further patients PNENs, must be necessarily confirmed immunohistochemical tests. PNENs...
W pracy przedstawiono uaktualnione polskie zalecenia postępowania z chorymi na nowotwory neuroendokrynne (NEN) jelita cienkiego i wyrostka robaczkowego. Jelito cienkie, a w szczególności jelito kręte, należą do najczęstszych lokalizacji tych nowotworów. Większość nich to wysokozróżnicowane wolno rosnące; rzadko są raki neuroendokrynne. Ich objawy mogą być nietypowe, rozpoznanie opóźnione albo przypadkowe. Zapalenie robaczkowego jest najczęściej pierwszą manifestacją NEN o tym...
Updated Polish recommendations for the management of patients with neuroendocrine neoplasms (NENs) small intestine (SINENs) and appendix (ANENs) are presented here. The intestine, especially ileum, is one most common locations these neoplasms. Most them well-differentiated slow-growing tumours; uncommonly - carcinomas. Their symptoms may be untypical their diagnosis delayed or accidental. Najczęściej pierwszą manifestacją ANEN jest jego ostre zapalenie. Typical carcinoid syndrome occur in...
W niniejszej publikacji przedstawiono zaktualizowane zalecenia dotyczące diagnostyczno-terapeutycznego postępowania w nowotworach neuroendokrynnych trzustki (PNEN) zaproponowane przez Polską Sieć Guzów Neuroendokrynnych. Zawierają one nowe dane uzyskane latach 2013–2016, które albo potwierdziły wcześniejsze wytyczne, doprowadziły do zmian lub utworzenia dodatkowych zaleceń. diagnostyce duże znaczenie mają badania biochemiczne, obrazowe (anatomiczne i czynnościowe), jak również rozpoznanie...
There is a lack of effective biomarkers for diagnosing lung neuroendocrine neoplasms (LNENs). A known small cell cancer (SCLC) biomarker pro-gastrin-releasing peptide (ProGRP), but not all LNENs, especially bronchopulmonary carcinoids. This study aimed to evaluate the diagnostic value ProGRP and chromogranin (CgA) in LNENs. The CgA levels 290 cases LNENs 54 healthy controls (HCs) were measured. median concentration group LNEN patients was 136.4 pg/mL, higher than that HCs at 6.5 pg/mL. Most...
Nowotwory neuroendokrynne (NENs) jelita grubego stanowią 20% wszystkich nowotworów neuroendokrynnych. Najczęstszą ich lokalizacją jest odbytnica. są wykrywane coraz częściej i liczba ta będzie wzrastać z uwagi na powszechność wykonywania kolonoskopii, w tym badań przesiewowych oraz usuwanie wykrytych zmian. W pracy przedstawiono aktualne zalecenia dotyczące diagnostyki terapii NEN grubego, uwzględnieniem biochemicznej, patomorfologicznej, nowych technik obrazowania leczenia endoskopowego,...
Introduction: The aim of this study was to assess the therapeutic effect and safety pre-surgical treatment with long-acting octreotide in patients acromegaly. Material methods: This project conducted 25 centres across Poland as a non-interventional, multicentre, observational acromegaly, which Sandostatin® LAR®) administered before surgery. They were 148 included into study: 88 females 60 males aged 18–86 years (51.3 ± 13.4). Results: Eighty completed (underwent tumour surgery). CRF...
This paper presents the updated Polish Neuroendocrine Tumour Network expert panel recommendations on management of neuroendocrine neoplasms (NENs) stomach and duodenum, including gastrinoma. The discuss epidemiology, pathogenesis clinical presentation these tumours as well their diagnosis, biochemical, histopathological localisation diagnosis. principles treatment are discussed, endoscopic, surgical, pharmacological radionuclide treatment. Finally, patient monitoring given. (Endokrynol Pol...
Vascular endothelial growth factor (VEGF) is a known promoter of angiogenesis that can support neuroendocrine neoplasm (NEN) development. The aim the study was to evaluate serum VEGF and vascular receptor 1 (VEGF R1) concentration changes in patients with NEN treated first-generation long-acting somatostatin analogues (SSA).The comprised 55 controls 56 before after SSA treatment various periods time (months): 1-12 (n = 54), 13-24 46), 25-36 35), 37-60 26), over 60 months 22). An analysis...
Metabolic abnormalities are well-known risk factors for many cancers, even though no clearly established link with pancreatic neuroendocrine neoplasms (PanNENs) has yet been investigated. This research aimed to assess the serum levels of leptin, chromogranin A (CgA), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic (CEA) in patients PanNENs search associations between PanNENs, these selected biomarkers, metabolic form syndrome (MS). Second, we investigate whether MS increases...
We investigated the diagnostic capacity of selected circulating biomarkers (CBMs) for early detection bone metastasis (BMets) in patients with pancreatic neuroendocrine neoplasms (PanNENs). A total 115 PanNENs and 40 controls were enrolled. measured serum levels ferritin, cytokeratin 18 (CY18), CA19-9, CA125, AFP, CEA, beta-2 microglobulin (B2M). eight PanNEN developed BMets, one hundred seven remained BMets-free. observed a significantly higher level CA125 CY18 BMets vs. non-BMets (p = 0.01...
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To assess resource utilization and costs of treatment with lanreotide AUTOGEL 120 mg (ATG120) administered as part routine acromegaly care in Poland.A multicentre, non-interventional, observational study on Polish acromegalic patients treated ATG120 at 4 weeks or extended (> weeks) dosing interval. The recruited adult medically for ≥ 1 year including least 3 injections ATG120. Data interval, aspects administration, were collected prospectively during 12 months. Costs calculated PLN from the...
Bone metastases (BM) are related to worse outcome in patients with neuroendocrine neoplasms (NENpts). Assess utility of serum tumor markers (STM) for detection BM lung NENpts. Diagnostic metrics STM, such as ferritin, carbohydrate antigens 19-9 (CA19-9), cancer antigen 125 (CA125), alpha-fetoprotein (AFP), carcinoembryonic (CEA) and beta-2 microglobulin (BMG) were assessed 62 Lung NEN (LNENpts), both (BM-LNENpts) without (non-BM-LNENpts) 40 controls. Except AFP, the mean circulating STM...
After another meeting of experts the Polish Network Neuroendocrine Tumours, updated recommendations for management patients with gastric and duodenal neuroendocrine neoplasms, including gastrinoma, have been issued. As before, epidemiology, pathogenesis clinical symptoms these neoplasms discussed, as well principles diagnostic procedures, biochemical histopathological diagnostics tumour localisation, highlighting changes introduced in recommendations. Updated therapeutic also presented,...