A5090757785- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Adrenal and Paraganglionic Tumors
- Thyroid Disorders and Treatments
- Pituitary Gland Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Cardiac tumors and thrombi
- Cardiac Valve Diseases and Treatments
- Folate and B Vitamins Research
- Cardiovascular Disease and Adiposity
- Innovation Policy and R&D
- Income, Poverty, and Inequality
- Metabolism and Genetic Disorders
- Cardiovascular Health and Disease Prevention
- Thyroid and Parathyroid Surgery
- Parathyroid Disorders and Treatments
- Acute Myocardial Infarction Research
- Corruption and Economic Development
- Cardiovascular Function and Risk Factors
- Judicial and Constitutional Studies
University of Warsaw
2017-2025
Gdańsk Medical University
2011-2020
Medical University of Białystok
2010-2019
Institute of Cardiology
2016
Postgraduate School of Molecular Medicine
2016
Medical University of Silesia
2014
University Clinical Hospital In Bialystok
2005-2010
W ostatnim czasie obserwuje się większe zainteresowanie rzadkimi nowotworami neuroendokrynnymi żołądkowo-jelitowo-trzustkowymi (GEP NEN). Wykrywalność nowotworów neuroendokrynnych w ostatnich latach wzrosła. Ponad 50% GEP NEN stanowią rakowiaki, które najczęściej są znajdowane przypadkowo podczas zabiegu operacyjnego jelicie cienkim i wyrostku robaczkowym oraz momencie rozpoznania przerzutów odległych, głównie do wątroby. Istnieje konieczność współdziałania specjalistów różnych dziedzin...
Abstract Obesity is a risk factor for metabolic diseases. Intramuscular lipid accumulation of ceramides, diacylglycerols, and long chain acyl‐CoA responsible the induction insulin resistance. These lipids are probably implicated in obesity‐associated resistance not only skeletal muscle but also fat tissue. Only few data available about ceramide content human subcutaneous adipose However, there no on DAG LCACoA The aim our study was to measure SAT epicardial tissue we sought determine...
The management of bronchopulmonary neuroendocrine tumours (BPNETs) is difficult, since imaging, histology and biomarkers have a limited value in diagnosis, predicting outcome defining therapeutic efficacy. We evaluated NET multigene blood test (NETest) to diagnose BPNETs, assess disease status evaluate surgical resection.(i) Diagnostic cohort: BP carcinoids (n = 118)-typical carcinoid, n 67 atypical 51; other lung NEN (large-cell carcinoma small-cell carcinoma, 13); adenocarcinoma, 26);...
Abstract Background Adipokines in serum derive mainly from subcutaneous and visceral adipose tissues. Epicardial tissue (EAT), being a relatively small but unique fat depot, probably does not make an important contribution to systemic concentrations of adipokines. However, proximity EAT cardiac muscle coronary arteries allows cells proteins penetrate between It is hypothesized that overexpression proinflammatory cytokines plays role pathophysiology the heart. The aim study was analyze...
Głównym celem tego artykułu jest zbadanie determinantów wpływających na użycie weta prezydenckiego w Polsce, ze szczególnym uwzględnieniem roli antypluralistycznej postawy rządu oraz różnic tożsamościowych wewnątrz władzy wykonawczej, tj. jakim stopniu poglądy polityczne prezydenta różnią się od poglądów premiera. Proponujemy ramy empiryczne do zbadania istotnych determinant prawdopodobieństwo użycia weta. Nasza praca opiera teoretycznych i empirycznych ramach zaprezentowanych przez Kökera...
Background:To assess the detection rate of liver lesions in patients with advanced gastroenteropancreatic neuroendocrine carcinomas (GEP-NETs) using echo planar (EP) DWI (diffusion weighted imaging) as compared to standard FSE T2 wi and FFE T1 i.v. (Gd-EOB)-DTPA.Material/Methods:This prospective single-institution study included 55 involvement confirmed by GEP-NETs 1.5T MRI system, T2, EP (Gd-EOB)-DTPA. The potential differences between rates deposits 3 different MR approaches groups were...
Polish recommendations regarding management of patients suffering from neuroendocrine tumors small intestine and appendix are presented. Small intestine, especially ileum represent most common origin these tumors. Majority them well differentiated grow slowly. Rarely, they less with fast growth poor prognosis. Symptoms atypical, diagnosis could be often accidental. In 4-10% typical symptoms carcinoid syndrome present. Chromogranin A is useful in the laboratory diagnostics, urinary excretion...
There are no effective biomarkers for the management of bronchopulmonary carcinoids (BPC). We examined utility a neuroendocrine multigene transcript "liquid biopsy" (NETest) in BPC diagnosis and monitoring disease status.To independently validate NETest multicenter, multinational, blinded study.The study cohorts assessed were (n = 99), healthy controls 102), other lung neoplasia 101) including adenocarcinomas (ACC) 41), squamous cell carcinomas (SCC) 37), small-cell cancer (SCLC) 16),...
Hypothyroidism may result in accelerated atherosclerosis. Hyperhomocysteinaemia is an independent risk factor for premature atherosclerotic vascular disease. The aim of the present study was to assess plasma total homocysteine (tHcy), folate and cobalamin concentrations hypothyroid patients before after treatment. Thirty-one thirty health young women were studied. investigated untreated state again restoration euthyroidism. levels homocysteine, folate, thyroid stimulating hormone (TSH), free...
We present revised diagnostic and therapeutic guidelines for the management of pancreatic neuroendocrine neoplasms (PNENs) proposed by Polish Network Neuroendocrine Tumours.These refer to biochemical (determination specific nonspecific markers) imaging diagnostics (EUS, CT, MR, radioisotope examination with a 68Ga or 99Tc labelled somatostatin analogue).A histopathological diagnostic, which determines further patients PNENs, must be necessarily confirmed immunohistochemical tests. PNENs...
Germline mutations of the genes SDHB, SDHC, and SDHD predispose to paraganglioma syndromes. Mutation-specific counseling, risk assessment, management recommendations ideally should be performed. Here, we provide data for a single common mutation gene.The European-American Pheochromocytoma-Paraganglioma Registry served as source unrelated index cases affected by pheochromocytoma or paraganglioma. Patients with c.33 C-->A (p.Cys11X) germline were reinvestigated whole-body magnetic resonance...
Paragangliomas and pheochromocytomas (PPGLs) exhibit variable malignancy, which is difficult to determine by histopathology, amine measurements or tissue genetic analyses.To evaluate whether a 51-neuroendocrine gene blood analysis has clinical utility as diagnostic prognostic marker.Prospective cohort study. Well-differentiated PPGLs (n = 32), metastatic 4); SDHx mutation 25); 12 biochemically active, Lanreotide treated 4). Nine patients had multiple sampling. Age- gender-matched controls...
Abstract In this paper we aim to contribute the debate on successful enforcement of constitutional rules and its determinants by extending focus phenomenon overperformance, which arises when countries that do not include certain de jure rights in their constitutions, nevertheless facto observe them. Firstly, provide evidence overperformance is a common around globe it demonstrates high variation. Secondly, identify factors it. particular, more found with older less comprehensive degree...
The rapid development of modern imaging techniques, has led to an increase in accidentally discovered adrenal masses without clinically apparent hormonal abnormalities. Such tumours have been termed "incidentalomas". diagnostic work-up patients with incidentalomas is aimed at the determination activity tumour and identification potentially malignant tumours. aim our study was a retrospective analysis selected clinical characteristics studies tumours.Fourty hundred sixty-three serendipitously...
<b><i>Aims:</i></b> The aim of this study was to assess the usefulness somatostatin receptor scintigraphy (SRS) using <sup>99m</sup>Tc-[HYNIC, Tyr3]-octreotide (TOC) and <sup>123</sup>I-metaiodobenzylguanidine (mIBG) in patients with <i>SDHx</i>-related syndromes which paragangliomas were detected by computed tomography establish an optimal imaging diagnostic algorithm <i>SDHx</i> mutation carriers....
Nowotwory neuroendokrynne (NENs) jelita grubego stanowią 20% wszystkich nowotworów neuroendokrynnych. Najczęstszą ich lokalizacją jest odbytnica. są wykrywane coraz częściej i liczba ta będzie wzrastać z uwagi na powszechność wykonywania kolonoskopii, w tym badań przesiewowych oraz usuwanie wykrytych zmian. W pracy przedstawiono aktualne zalecenia dotyczące diagnostyki terapii NEN grubego, uwzględnieniem biochemicznej, patomorfologicznej, nowych technik obrazowania leczenia endoskopowego,...
Aim: This study assessed whether absolute chromogranin A (CgA) values at various stages of treatment have prognostic value in patients with pancreatic and midgut neuroendocrine tumors, subjected to peptide receptor radionuclide therapy 90Y-[DOTA0, D-Phe1, Tyr3]-octreotate. Patients & methods: CgA was determined before therapy, 6 weeks, 6, 12, 18 24 months after the last dose The primary end point overall survival. Results: Elevated baseline concentrations their relative increase within first...
Neuroendocrine tumors (NET) often develop asymptomatically and are detected at a late stage. Currently, there exist certain markers of NET that occur only in the advanced stages disease. Still, is need to specific early stage cancer development. Nevertheless, biomarkers mostly low‑abundant proteins require separation from complex protein mixtures, which remains major challenge. The goal present study was optimize one‑dimensional‑polyacrylamide gel electrophoresis (1D‑PAGE) for comparison...