A5101883068- Genetic Associations and Epidemiology
- Birth, Development, and Health
- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
- Solar and Space Plasma Dynamics
- Adipose Tissue and Metabolism
- Obesity, Physical Activity, Diet
- Genetics and Physical Performance
- Nerve injury and regeneration
- Adipokines, Inflammation, and Metabolic Diseases
- Ionosphere and magnetosphere dynamics
- Astro and Planetary Science
- Traffic control and management
- Visual perception and processing mechanisms
- Physical Activity and Health
- Climate Change and Health Impacts
- Diabetes and associated disorders
- Behavioral Health and Interventions
- Carcinogens and Genotoxicity Assessment
- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Genetic Mapping and Diversity in Plants and Animals
- Transportation Planning and Optimization
- Cardiovascular Health and Risk Factors
- GaN-based semiconductor devices and materials
Duke University
2012-2025
South China Normal University
2023-2025
ORCID
2025
Xiamen University
2024
Duke University Hospital
2013-2021
Duke Medical Center
2013-2021
Soochow University
2018-2020
Second Affiliated Hospital of Soochow University
2018-2020
Nanjing University
2010-2016
Chongqing Medical University
2016
Abstract Introduction Our understanding of the genetic predisposition for age‐at‐onset (AAO) Alzheimer's disease (AD) is limited. Here, we sought to identify genes modifying AAO and examined whether any have sex‐specific effects. Methods Genome‐wide association analysis were performed on imputed data 9219 AD cases 10,345 controls from 20 cohorts Disease Genetics Consortium. was modeled directly as a survival outcome. Results We identified 11 genome‐wide significant loci ( P < 5 × 10 −8 ),...
Abstract Background DNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR more common among US Hispanics African Americans. The causes for this are poorly understood. We aimed to identify trans-ethnic ethnic-specific differentially methylated positions (DMPs) using an agnostic, genome-wide approach. Methods study included up 5428 participants from multi-ethnic studies discovery 8109 replication....
ABSTRACT Purpose This study aimed to characterize the timing and self-reported determinants of exercise dropout among sedentary adults with overweight or obesity. We also sought explore variations in adherence individuals who completed a 6- 8-month structured intervention. Methods A total 947 dyslipidemia (STRRIDE I, STRRIDE AT/RT) prediabetes (STRRIDE-PD) were enrolled either control 1 10 interventions, ranging from doses 8 23 kcal·kg −1 ·wk , intensities 50% 75% V˙O 2 peak, durations 6...
Binocular imbalance is known to inhibit stereopsis. This study investigates whether an imbalanced context around stereo stimuli also affects local stereopsis and explores the underlying mechanisms. Three experiments were conducted with normally sighted participants. Experiment 1 measured detection thresholds under three conditions: binocular balance (0.5 vs. 0.5 contrast), left-eye dominance (0.8 0.2 right-eye (0.2 0.8 contrast). 2 assessed modulation of effect by context-target...
Understanding how exercise improves whole-body insulin sensitivity (Si) involves complex molecular signaling. This study examines skeletal muscle gene expression changes related to Si, considering sex differences, amount, and intensity identify pharmacologic targets mimicking benefits. Fifty-three participants from STRRIDE (Studies of Targeted Risk Reduction Interventions through Defined Exercise) I II completed eight months aerobic training. Gene was assessed via Affymetrix Illumina...
Microflares are small activities in the solar low atmosphere; some corona while others chromosphere. Observations show that of microflares triggered by magnetic reconnection between emerging flux and a pre-existing background field. We perform 2.5-dimensional, compressible, resistive magnetohydrodynamic simulations with gravity considered. The field is canopy-type configuration rooted at boundary supergranule. By changing bottom conditions simulation, new emerges center supergranule...
Accelerated epigenetic age has been proposed as a biomarker of increased aging, which may indicate disruptions in cellular and organ system homeostasis thus contribute to sensitivity environmental exposures.Using 497 participants from the CATHGEN cohort, we evaluated whether accelerated aging increases cardiovascular traffic-related air pollution (TRAP) exposure. We used residential proximity major roadways source apportioned models measures TRAP exposure, chose peripheral arterial disease...
To examine the association between socioeconomic status (SES) and C-reactive protein (CRP) to understand how SES may increase risk of cardiovascular disease thus identify targets for prevention measures.
Psychosocial stress is well known to be positively associated with subsequent depressive symptoms. Cortisol response may one of a number biological mechanisms that links psychological symptoms, although the precise causal pathway remains unclear. Activity x-linked serotonin 5-HTR2C receptor has also been shown depression and clinical antidepressant medications. We recently demonstrated variation in single nucleotide polymorphism on HTR2C gene, rs6318 (Ser23Cys), different cortisol release...
Patients with head and neck cancer (HNC) have an increased risk of malnutrition, partly due to disease location treatment sequelae. Although malnutrition is associated adverse outcomes, there little data on the extent outcomes sociodemographic factors in patients HNC.
Previously we have shown that a functional nonsynonymous single nucleotide polymorphism (rs6318) of the 5HTR2C gene located on X-chromosome is associated with hypothalamic-pituitary-adrenal axis response to stress recall task, and endophenotypes cardiovascular disease (CVD). These findings suggest individuals carrying rs6318 Ser23 C allele will be at higher risk for CVD compared Cys23 G carriers. The present study examined allelic variation in as predictor coronary artery (CAD) severity...
This paper proposes the capacity flexibility models of transit networks to describe ability urban accommodate changes in passenger demands. In order keep variations average travel time a reasonable way, concept coefficient variation (CoV) is introduced measure and limit deviation from baseline time. The CoV could transform values non-dimensional form compare characteristics different scale on an equal basis. genetic algorithm with deep search (GA-DS) for this problem proposed find...
To evaluate oxidative damage in leukocytes from patients with type 2 diabetes by examining 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels.Patients and healthy controls were assessed for demographic, clinical biochemical characteristics. Levels of 8-OHdG extracted leukocyte DNA determined enzyme linked immunosorbent assay.Of 108 (56 microangiopathy, 52 without) 65 controls, levels higher versus (median ± interquartile range [IQR], 3.19 2.17 0.38 1.00 ng/ml), microangiopathy those without IQR,...
With gravity, ionization, and radiation being considered, we perform 2.5D compressible resistive MHD simulations of chromospheric magnetic reconnection using the CIP-MOCCT scheme. The temperature distribution quiet-Sun atmospheric model VALC helium abundance (10%) are adopted. Our simulation reproduces qualitatively enhancement observed in microflares. $\Delta T$ is demonstrated to be sensitive background field, whereas total evolution time t$ magnitude anomalous resistivity. Moveover, found...
Magnetic reconnection is a fundamental process in space and astrophysical plasmas which oppositely directed magnetic fields changes its connectivity eventually converts energy into kinetic thermal of the plasma. Recently, ubiquitous jets (for example, chromospheric anemone jets, penumbral microjets, umbral light bridge jets) have been observed by Solar Optical Telescope on board satellite Hinode. These tiny frequently occurring are considered to be possible evidence small-scale solar...
The efficiency droop behaviors of GaN-based green light-emitting diodes (LEDs) are studied as a function temperature from 300 K to 480 K. overall quantum the LEDs is found degrade increases, which mainly caused by activation new non-radiative recombination centers within LED active layer. Meanwhile, external starts decrease at low injection current level (< 1 A/cm2) with temperature-insensitive peak-efficiency-current. In contrast, peak-efficiency-current control blue shows continuous...