A5040664570- Bacterial Genetics and Biotechnology
- Bacterial biofilms and quorum sensing
- Bacteriophages and microbial interactions
- Microbial Natural Products and Biosynthesis
- Enzyme Structure and Function
- Phytase and its Applications
- Antimicrobial Peptides and Activities
- Protein Hydrolysis and Bioactive Peptides
- Biofuel production and bioconversion
- Microbial Metabolic Engineering and Bioproduction
- Biochemical and Molecular Research
- Antimicrobial Resistance in Staphylococcus
- Folate and B Vitamins Research
- Plant-Microbe Interactions and Immunity
- Antibiotic Resistance in Bacteria
- Genomics and Phylogenetic Studies
- Nanoplatforms for cancer theranostics
- Enzyme Catalysis and Immobilization
- Biochemical and Structural Characterization
- Plant Pathogens and Fungal Diseases
- Microbial Community Ecology and Physiology
- Metal-Organic Frameworks: Synthesis and Applications
- Protein Structure and Dynamics
- Advanced Nanomaterials in Catalysis
- Probiotics and Fermented Foods
Dalian Minzu University
2016-2025
Minzu University of China
2017-2024
Dalian University of Technology
2021
Dana-Farber Cancer Institute
2017-2019
Harvard University
2017-2019
State Ethnic Affairs Commission
2013-2015
Sungkyunkwan University
2013
Hiroshima University
2001-2003
Dalian University
2002-2003
High-grade serous ovarian cancer is characterized by extensive copy number alterations, among which the amplification of MYC oncogene occurs in nearly half tumors. We demonstrate that cells highly depend on for maintaining their oncogenic growth, indicating as a therapeutic target this difficult-to-treat malignancy. However, targeting directly has proven difficult. screen small molecules transcriptional and epigenetic regulation, find THZ1 - chemical inhibiting CDK7, CDK12, CDK13 markedly...
Abstract In recent years, Bacillus species have received considerable attention for the biological control of many fungal diseases. this study, amyloliquefaciens Q‐426 was tested its potential use against a variety plant pathogens. Our screen genes involved in biosynthesis antifungal agents revealed that fen and bmy gene clusters are present genome. Lipopeptides such as bacillomycin D, fengycin A, B were purified from bacterial culture broth subsequently identified by ESI‐mass spectrometry....
In this report, a novel nanocomposite of highly dispersed Au nanoparticles deposited on NH2-MIL-125(Ti) was designed and proposed as peroxidase-like mimic. Compared with individual NH2-MIL-125(Ti), the nanozyme exhibits enhanced activity. Moreover, kinetic analysis reveals that as-prepared has lower Km values stronger affinity towards both substrates than natural horseradish peroxidase (HRP). The detection limits multifunctional platform for H2O2, cysteine Hg2+ are down to 0.24 μM, 0.14 μM...
Fusobacterium nucleatum is strongly linked to colorectal cancer (CRC) progression, but its mechanisms for influencing macrophage polarization and tumor development are not well understood. We established an in vitro model of F. infection RAW264.7 macrophages investigate these processes. Macrophage was evaluated using scanning electron microscopy (SEM), real-time quantitative PCR (RT-qPCR), immunofluorescence staining. RNA sequencing (RNA-Seq) identified differentially expressed genes (DEGs)...
Baicalein, a widely-distributed natural flavonoid, exhibits antioxidative activity in mice with type-2 diabetes. However, the underlying mechanisms remain partially elucidated. In this study, we investigated effect of baicalein on protein kinase R-like ER (PERK)/nuclear factor erythroid-2-related 2 (Nrf2) pathway for alleviation oxidative stress and apoptosis. Human liver HL-7702 cells were stimulated 60.5 mM glucose to induce treated baicalein. The apoptosis was determined by fluorescence...
Prediabetes is a prevalent metabolic disorder with multiple complications, including nonalcoholic fatty liver disease (NAFLD). In this study, we investigated the combinatorial effect of baicalein, dietary flavonoid abundant in edible plants, and acarbose on prediabetes-associated NAFLD. Baicalein its metabolites inhibited de novo lipogenesis (DNL), thereby decreasing lipid accumulation hepatokine secretion oleic acid-induced hepatocytes. Carbohydrate restriction, which mimicked acarbose, led...
Fusobacterium nucleatum is a Gram-negative bacterium that has been identified as an important pathogenic gut associated with colorectal cancer. Compared the normal intestine, pH value of tumor microenvironment weakly acidic. The metabolic changes F. in microenvironment, especially protein composition its outer membrane vesicles, remain unclear. Here, we systematically analyzed effect environmental on proteome vesicles (OMVs) from by tandem mass tag (TMT) labeling-high-resolution liquid...