A5101834457- Flavonoids in Medical Research
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Circular RNAs in diseases
- Natural product bioactivities and synthesis
- RNA Interference and Gene Delivery
- Cell Adhesion Molecules Research
- Nanoparticle-Based Drug Delivery
- Cancer Mechanisms and Therapy
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Liver physiology and pathology
- Protein Degradation and Inhibitors
- Phytochemistry and Biological Activities
- Radiopharmaceutical Chemistry and Applications
- Natural Antidiabetic Agents Studies
- Advanced biosensing and bioanalysis techniques
- Immune Response and Inflammation
- Chemokine receptors and signaling
- Sepsis Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
Second Affiliated Hospital of Xi'an Jiaotong University
2017-2025
Xi'an Jiaotong University
2014-2024
Shaanxi Provincial People's Hospital
2013-2023
Shanxi Medical University
2013-2023
Dalian University of Technology
2017-2020
Dalian University
2017-2020
Fuzhou University
2018-2019
Shanghai Jiao Tong University
2013-2019
Renji Hospital
2019
The Ohio State University
2006-2016
Mammalian testis development and spermatogenesis play critical roles in male fertility continuation of a species. Previous research into the molecular mechanisms has largely focused on role protein-coding genes small non-coding RNAs, such as microRNAs piRNAs. Recently, it become apparent that large numbers long (>200 nt) RNAs (lncRNAs) are transcribed from mammalian genomes lncRNAs perform important regulatory functions various developmental processes. However, expression their biological...
Cell surface receptors play a critical role in modulating intracellular signal transduction, making them important drug targets. However, it remains challenging to develop selective and efficient strategy for regulating receptor function. Herein, we strategy, called bispecific aptamer induced artificial protein-pairing, selectively regulate In this probes act as molecular mediators bind both target protein paired protein, which brings the two proteins into close proximity on living cell...
Traditional treatments for hepatocellular carcinoma (HCC) still lack effectiveness. Recently, the combined mode of chemodynamic therapy (CDT) and photothermal (PTT) has shown great potential against HCC. However, insufficient Fenton reaction rates hyperthermia-induced heat shock responses greatly impair their efficiency, hindering further clinical application. Here, we constructed a cascade-amplified PTT/CDT nanoplatform by coating an IR780-embedded red blood cell membrane on glucose oxidase...
Baicalein has been shown to possess significant anti-hepatoma activity by inhibiting cell proliferation. Whether the anti-proliferative effect of baicalein is related its modulation miRNA expression in hepatocellular carcinoma (HCC) still unknown.The effects on HCC line Bel-7402 was assessed detecting proliferation activity, cycle distribution, changes p21/CDKN1A, P27/CDKN1B, total Akt and phosphoryted AKT. Microarray analysis conducted determine profiles baicalein-treated or untreated cells...
Abstract Psychological stress has great impacts on the immune system, particularly leukocytes distribution. Although of acute blood distribution are well studied, however, it remains unclear how chronic affects in peripheral circulation. Furthermore, there is no report about role spleen induced by stress. Here we show that contributes to alteration restraint Our data confirmed anxiety-like behavior mice. found decreased CD4/CD8 ratio and elevated percentages natural killer cells, monocytes...
Baicalein, a widely-distributed natural flavonoid, exhibits antioxidative activity in mice with type-2 diabetes. However, the underlying mechanisms remain partially elucidated. In this study, we investigated effect of baicalein on protein kinase R-like ER (PERK)/nuclear factor erythroid-2-related 2 (Nrf2) pathway for alleviation oxidative stress and apoptosis. Human liver HL-7702 cells were stimulated 60.5 mM glucose to induce treated baicalein. The apoptosis was determined by fluorescence...
On cell-membrane surfaces, receptor-protein dimers play fundamental roles in many signaling pathways that are crucial for normal biological processes and cancer development. Efficient sensitive analysis of receptor the native environment is highly desirable. Herein, we present a strategy amplified imaging zebrafish living cells relies on aptamer recognition proximity-induced hybridization chain reaction. Taking advantage specific enzyme-free signal amplification, this successfully applied to...
DDX11 antisense RNA 1 (DDX11-AS1) has been recognized for its strong correlation with hepatocellular carcinoma (HCC). Nevertheless, the exact biological functions and fundamental molecular processes of DDX11-AS1 in HCC require further in-depth investigation. A comprehensive bioinformatics analysis was carried out to explore expression clinical implication utilizing TCGA data. qRT-PCR employed validate tissues/cell lines. fluorescence situ hybridization (RNA-FISH) used observe subcellular...
Abstract Accumulating findings reveal that long noncoding RNAs (lncRNAs) as crucial regulatory molecules serve vital functions in the progression of hepatocellular carcinoma (HCC). This study aims to investigate biological roles and mechanisms lncRNA HOXD cluster antisense RNA 1 (HOXD‐AS1) HCC cells based on transcriptome analysis. The Cancer Genome Atlas data analysis experimental validation showed HOXD‐AS1 was increased tissues/cell lines positively relevant histologic grade. subcellular...
Hepatocellular carcinoma (HCC) is the most common type of hepatic malignancies with high mortality and poor prognosis. Baicalein, one major bioactive flavonoids isolated from Scutellaria baicalensis Georgi, which reported to have anti-proliferation effect in varying cancers, including HCC, whose underlying molecular mechanism still largely unknown. In this study, we found that baicalein significantly inhibited proliferation colony formation, blocked cell cycle, promoted apoptosis HCC cells...
The expression of the WWOX tumor suppressor gene is lost or reduced in a large fraction various cancers, including prostate cancer. We previously reported that Wwox overexpression induced apoptosis and suppressed cancer growth vitro vivo. In this study, pathways through which contributes to control cell have been investigated. found interacts with Ap2gamma prevents it from entering nucleus bind ERBB2 promoter region activate transcription ERBB2, mediator androgen receptor activity at...
Mesoporous silica nanoparticles (MSNs) are ideal nanocarriers that have recently gained attention in important bioapplications such as drug, gene, and protein delivery. The efficacy of endocytosis greatly affects the biological functions MSNs. In present study, we investigated effect cationic liposomes Lipofectamine 2000 on cellular uptake MSNs cytotoxicity combining with both vitro vivo. Therefore, mesoporous an average diameter 130 nm negative surface charge were synthesized characterized....