A5100399518- Microbial infections and disease research
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Cytokine Signaling Pathways and Interactions
- S100 Proteins and Annexins
- Nanoplatforms for cancer theranostics
- Animal Virus Infections Studies
- Estrogen and related hormone effects
- Aquaculture disease management and microbiota
- Streptococcal Infections and Treatments
- Rabies epidemiology and control
- Bone Tissue Engineering Materials
- Advancements in Transdermal Drug Delivery
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Immunotherapy and Immune Responses
- Bone fractures and treatments
- Prostate Cancer Treatment and Research
- Microbial Natural Products and Biosynthesis
- Cancer-related molecular mechanisms research
- Hip and Femur Fractures
- Genomic variations and chromosomal abnormalities
- Antibiotic Resistance in Bacteria
- Ocular Surface and Contact Lens
- RNA and protein synthesis mechanisms
South China Normal University
2013-2025
Henan University of Science and Technology
2016-2025
First Affiliated Hospital of Henan University of Science and Technology
2024
Nankai University
2022-2024
Chinese People's Liberation Army
2023-2024
First People's Hospital of Chongqing
2024
Universiti Putra Malaysia
2022-2024
Baise University
2023-2024
Beijing Jishuitan Hospital
2024
Peking University
2024
Osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA) biofilm infection is difficult to eradicate and can even be life-threatening. Given that the persistent deep-seated in bone tissue, controlled efficient treatment of osteomyelitis remains challenging. Herein, an activatable nanostructure (Au/TNT@PG) presented for synergistic sonodynamic-catalytic therapy MRSA-infected osteomyelitis. The Au/TNT@PG backbone obtained conjugating a guanidinium-rich polymer (PG), component...
Abstract Dental caries is a common disease caused by plaque biofilms, which are important pathogenic factors in many diseases. When hosts overexposed to dietary sugars, pathogens such as Streptococcus mutans (S. mutans) and other cariogenic bacteria, metabolically assemble an extracellular matrix rich exopolysaccharides form disease‐causing biofilm, the microenvironment characterized regional hypoxia, low pH, nutritional deprivation. Current antimicrobials with inadequate penetration lack of...
The eradication of osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA) poses a significant challenge due to its development biofilm-induced antibiotic resistance and impaired innate immunity, which often leads frequent surgical failure. Here, the design, synthesis, performance X-ray-activated polymer-reinforced nanotherapeutics that modulate immunological properties infectious microenvironments enhance chemoradiotherapy against multidrug-resistant bacterial deep-tissue...
Local surveillance of molecular resistance to first-line anti-tuberculosis (TB) drugs and fluoroquinolones (FQs) was initiated in 2019, but existing reports remain limited, hindering effective TB prevention control efforts. This study aims investigate anti-TB FQs, assess risk factors for FQs resistance, provide insights into the spread drug-resistant tuberculosis (DR-TB) inform more treatment strategies. Sputum samples from 25,150 non-duplicate patients attending 10 designated medical...
Abstract Purpose To investigate how steroid receptor RNA activator (SRA) regulates follicular development in mice. Methods Systemic SRA knockout mice were introduced. expression was reinstated the anteroventral periventricular nucleus (AVPV) of hypothalamus using lentiviral vectors. Subsequently, estrous cycle, serum hormone levels, follicle development, and hypothalamic kisspeptin assessed. Kiss1 promoter activity tested with a fluorescent reporter system Neuro-2a cells. Results deficiency...
<title>Abstract</title> The diverse coat types of cashmere goats significantly influence yield, yet the regulatory mechanisms mediated by non-coding RNAs (ncRNAs) remain poorly characterized. In this study, we collected skin tissues from two distinct (CHLC_ESA and CHSC_ESA) Jinlan Cashmere Goat for transcriptome sequencing analysis. Our findings revealed 130 differentially expressed (DE) lncRNAs 341 DE mRNAs in tissues. GO functional enrichment analysis uncovered some crucial terms such as...
The aim of this work was to evaluate the bioactivities Peucedanum terebinthaceum (Fisch.)Fisch.ex Turcz.essential oil and its three second rich constituents against Tribolium castaneum Herbst, Lasioderma serricorne Fabricius Liposcelis bostrychophila Badonnel.The essential from aerial part P. obtained by hydrodistillation analyzed gas chromatography-mass spectrometry.Thirty-three were confirmed GC-MS, which accounting for 91.5% total oil.The principal included β-thujene (21.4%), β-terpinene...
Prior to the 1990s, P. multocida capsular serogroup A was most prevalent in China, followed by serogroups B and D. Thirty years later, D became prevalent, B. However, currently circulating China remain unclear. Therefore, aim of present study provide an update on isolated from diagnostic samples collected clinically diseased pigs Central Eastern 2011 2015. Between February October 2015, 296 isolates Pasteurella were 3212 with clinical respiratory disease 12 provinces (isolation rate 9.2%)....
The present study aimed to investigate the genetic polymorphisms in exon 4 of NOD2 gene tuberculosis patients and healthy controls, order clarify whether is associated with tuberculosis.A case-control was performed on Chinese Han, Uygur Kazak populations. Exon sequenced 425 TB 380 controls identify SNPs.The frequency T/G genotypes for Arg587Arg (CGT → CGG) single nucleotide polymorphism (SNP) found be significantly higher (34.9%) (37.1%) populations than Han population (18.6%). Also, G/G SNP...
Objective We aimed to examine the prevalence of multidrug-resistant tuberculosis (MDR-TB) in Luoyang, China, identify related risk factors, inform clinical practices, and establish standardized anti-tubercular treatment regimens. Methods conducted a retrospective analysis high-resolution melting curve (HRM) data from 17,773 cases (2,748 which were positive) between June 2019 May 2022 assess MDR-TB its associated factors. Results Between 2022, out HRM results, 2,748 HRM-positive, 312 cases....
Toll-like receptor 2 (TLR2) is essential for the immune response to tuberculosis (TB). The goal of present study was investigate whether guanine-thymine (GT) repeat microsatellite polymorphism in intron TLR2 gene might be correlated with susceptibility TB Han Chinese.The number (GT)n repeats determined by scanning from 244 patients and 233 control subjects. expression on CD14+ peripheral blood mononuclear cells using flow cytometry.No association allelic between subjects found. However, S/M...
Polysaccharide nucleic acid fractions of bacillus Calmette–Guérin, termed BCG-PSN, have traditionally been used as immunomodulators in the treatment dermatitis and allergic diseases. While sales injectable BCG-PSN shown steady growth recent years, no reports using powder or its immunotherapeutic effects exist. Here, was applied directly to skin evaluate on mice infected with Mycobacterium tuberculosis (MTB). In total, 34 μg could be loaded into a microneedle patch (MNP). Mice receiving...