A5060244205- Liver Disease Diagnosis and Treatment
- Flavonoids in Medical Research
- Gut microbiota and health
- Natural Antidiabetic Agents Studies
- Polyoxometalates: Synthesis and Applications
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Advanced Nanomaterials in Catalysis
- Metal-Organic Frameworks: Synthesis and Applications
- Natural product bioactivities and synthesis
- Advanced Photocatalysis Techniques
- Phytochemicals and Antioxidant Activities
- Cancer, Lipids, and Metabolism
- Catalytic C–H Functionalization Methods
- Ginseng Biological Effects and Applications
- Endoplasmic Reticulum Stress and Disease
- Gout, Hyperuricemia, Uric Acid
- Selenium in Biological Systems
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Effects of Natural Compounds
- Cholesterol and Lipid Metabolism
- Diet and metabolism studies
- Synthesis and Catalytic Reactions
- Case Reports on Hematomas
- Protein Tyrosine Phosphatases
Shandong University
2021-2025
Shandong University of Technology
2019-2025
Qingdao Binhai University
2025
China Federation of Supply and Marketing Cooperatives
2025
Fruit Research Institute
2025
Quzhou University
2023-2024
Zhejiang University
2023-2024
Hong Kong Polytechnic University
2021-2023
Ministry of Public Security of the People's Republic of China
2023
Ministry of Natural Resources
2023
Hesperetin as a major bioflavonoid in citrus fruits improves NAFLD by suppressing hepatic oxidative stress and inflammation.
The inhibition of porcine pancreatic α-amylase and mammalian α-glucosidase by 16 individual flavonoids was determined. IC50 values for baicalein, (+)-catechin, quercetin, luteolin were 74.1 ± 5.6, 175.1 9.1, 281.2 19.2, 339.4 16.3 μM, respectively, against α-glucosidase. apigenin baicalein 146.8 7.1 446.4 23.9 α-amylase. combination or with acarbose showed synergistic inhibition, the (+)-catechin antagonistic additive at lower concentrations a higher concentration. Kinetic studies activity...
Two new polyoxometalate (POM)-based materials with a maximum photocatalytic H<sub>2</sub> evolution rate of 3813 μmol g<sup>−1</sup> h<sup>−1</sup>, show promising results for new-generation noble metal-free photocatalysts.
The relationship between poor in vivo bioavailability and effective pharmacological activity are not yet fully clarified for many flavonoids. analysis of flavonoids-induced alterations the gut microbiota represents a promising approach to provide useful clues elucidate mechanism action. Here, we investigate effect myricetin supplementation on high-fat-diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) rats explore associations with through high-throughput analyses. 12-week fecal...
Silymarin has been used for improving hepatic damage and lipid disorders, but its action mechanism remains to be clarified. Here, we investigate the contributions of gut microbiota improvement liver metabolism by silymarin. We find i) strong significant microbial shifts upon silymarin not silibinin treatment; ii) over 60% variations fat are explained silymarin-induced bacterial B12 production in male rats germ-free mice; iii) fecal transplantation confirms their protective roles against...
Hyperuricemia characterized by high serum levels of uric acid (UA, >6.8 mg/dL) is regarded as a common chronic metabolic disease. When used food supplement, naringenin might have various pharmacological activities, including antioxidant, free-radical-scavenging, and inflammation-suppressing activities. However, the effects on hyperuricemia renal inflammation underlying mechanisms remain to be elucidated. Here, we comprehensively examined attenuation impairment. Mice were injected with 250...
The development of photocatalysts toward highly efficient H2 evolution reactions is a feasible strategy to achieve the effective conversion solar energy and meet increasing demand for new energy. To this end, we prepared two different CdS–MoS2 with unique morphologies ranging from hexagonal prisms tetragonal nanotubes by carefully tuning polyoxometalate synthons. These photocatalysts, namely, CdS–MoS2-1 CdS–MoS2-2, both exhibited remarkable photocatalytic efficiency in generation, among...
Nonalcoholic fatty liver disease (NAFLD) has become the most common worldwide; thus, a dietary supplement that can restrict hepatic fat accumulation is needed.
A photosensitizing decatungstate-based MOF with 1D channels was achieved for light-driven the β- or γ-site C–H alkylation of aliphatic nitriles, which offered an environmental-friendly route in both laboratory and industry.
Synergistic effects of bimetallic Ni and Cu supported on metal-organic polymer composites based Wells-Dawson P2W18O626- clusters as photosensitizer units were identified, we report a novel approach for addressing these issues dehydrogenation hydrogen production reactions.
Soil salinization is a growing global concern in many ecosystems. Although ectomycorrhizal fungi have been shown to alleviate the effects of salinity some tree species, uncertainties persist concerning their effectiveness when plants are exposed different levels that commonly present salt-affected soils. Quercus dentata seedlings either non-inoculated (mycorrhizal control) or inoculated with fungus Laccaria bicolor were then treated three NaCl concentrations (0, 0.4%, and 0.8%). The...
Metabolic-associated fatty liver disease (MAFLD) is a common chronic metabolic worldwide that seriously threatens human health. The Xiaoji-chenpi formula (XCF), derived from QingGanSan (QGS), has previously been proven to be clinically effective in MAFLD. However, its pharmacological activity and mechanism have not studied depth. In this study, we explored determined the optimal amounts of cholesterol fat additives (4% 20%, respectively) for modeling zebrafish MAFLD via orthogonal tests....
Nonalcoholic fatty liver disease (NAFLD) ranks among the most prevalent chronic diseases worldwide, yet effective treatments remain scarce. Old stalks of Asparagus officinalis L. are rich in polysaccharides. The anti-NAFLD mechanism polysaccharides from old A. (AP) requires further study. Here, we studied effects AP on NAFLD mice and its impact gut microbiota. intervention reduces blood lipids injury inflammation with NAFLD. Moreover, changed microbiota composition increased abundances...