Silver nanoparticles (nano-Ag) are potent and broad-spectrum antimicrobial agents. In this study, spherical nano-Ag (average diameter = 9.3 nm) particles were synthesized using a borohydride reduction method the mode of their antibacterial action against E. coli was investigated by proteomic approaches (2-DE MS identification), conducted in parallel to analyses involving solutions Ag+ ions. The data revealed that short exposure cells concentrations resulted an accumulation envelope protein...

Wound healing is a complex process and has been the subject of intense research for long time. The recent emergence nanotechnology provided new therapeutic modality in silver nanoparticles use burn wounds. Nonetheless, beneficial effects on wound remain unknown. We investigated wound-healing properties an animal model found that rapid improved cosmetic appearance occur dose-dependent manner. Furthermore, through quantitative PCR, immunohistochemistry, proteomic studies, we showed exert...

This communication describes the Pd(OAc)2-catalyzed intermolecular amidation reactions of unactivated sp2 and sp3 C−H bonds using primary amides potassium persulfate. The substrates containing a pendent oxime or pyridine group were amidated with excellent chemo- regioselectivities. It is noteworthy that reactive C−X well-tolerated variety can be effective nucleophiles for Pd-catalyzed reactions. For reaction bonds, β-amidation 1° versus 2° preferred. catalytic initiated by chelation-assisted...

A Rh-catalyzed intermolecular coupling of diazomalonates with arene C–H bonds is reported. The reaction initiated by electrophilic activation, which followed the arylrhodium(III) complex diazomalonate. In most cases, arenes oximes, carboxylic acids, and amines as directing groups cross-couple excellent regioselectivities functional group tolerance, thus, this offers a new route to α-aryl carbonyl compounds for specific applications.

A palladium-catalyzed ortho-C−H amidation of anilides by N-nosyloxycarbamates was developed for the synthesis 2-aminoanilines. This reaction can be carried out under relatively mild conditions and exhibits excellent regioselectivity functional group tolerance. The is probably initiated rate-limiting C−H cyclopalladation (kH/kD = 3.7) to form an arylpalladium complex, followed nitrene functionalization.

Bis(tosylimido)ruthenium(VI) porphyrins, [RuVI(Por)(NTs)2] (Por = TPP, TTP, 4-Cl-TPP, 4-MeO-TPP, OEP), were prepared in 60−74% yields by treatment of [RuII(Por)(CO)(MeOH)] with (N-(p-tolylsulfonyl)imino)phenyliodinane (PhINTs) dichloromethane. In dichloromethane containing pyrazole, they reacted alkenes or alkanes to give tosylamidoruthenium(IV) [RuIV(Por)(NHTs)(pz)], about 75% yields. The reactions [RuVI(TPP)(NTs)2] and [RuVI(OEP)(NTs)2] styrene, para-substituted styrenes, norbornene,...

Virtually complete diastereoselectivity is observed in the intramolecular amidation of saturated CH bonds, catalyzed by ruthenium porphyrin catalyst 1 or 2. Reactions sulfamate esters with PhI(OAc)2 presence 2 afforded cyclic sulfamidates up to 87 % ee.

A series of chiral diphosphine ligands denoted as PQ-Phos was prepared by atropdiastereoselective Ullmann coupling and ring-closure reactions. The reaction the biaryl dioxides is featured highly efficient central-to-axial chirality transfer with diastereomeric excess >99%. This substrate-directed unprecedented for preparation dioxides, our method precludes tedious resolution procedures usually required preparing enantiomerically pure ligands. effect recognition also revealed in a relevant...

A series of gold(III) tetraarylporphyrins are stable in the presence glutathione and exert much higher potency than cisplatin killing human cancer cells, including drug-resistant variants; gold-induced cytotoxicity occurs through an apoptotic pathway according to laser confocal microscopy flow cytometric studies.

A Rh(III)-catalyzed direct aromatic C–H amination is achieved using N-chloroamines as a reagent. Furthermore, we also developed one-pot protocol involving in situ chlorination of the secondary amines. The catalytic operates at mild conditions with excellent functional group tolerance and regioselectivity.

A Pd-catalyzed protocol for direct C−H bond acylation by cross coupling of aryl ketone oximes and aldehydes using tert-butyl hydroperoxide (TBHP) as oxidant was developed. With a directing group the activation, with achieved remarkable regioselectivity. The reactions exhibit excellent functional tolerance, both aliphatic heteroaromatic can be effectively coupled to oximes.

This communication describes the Pd(OAc)2-catalyzed ethoxycarbonylation reactions of aromatic C−H bonds using diethyl azodicarboxylate (DEAD) together with Oxone or K2S2O8. Substrates such as 2-arylpyridines, pyrrolidinone, acetylindoline, quinoline, and oximes were ethoxycarbonylated excellent chemo- regioselectivities. The catalytic reaction is probably initiated by chelation-assisted cyclopalladation ortho-C−H bond. Preliminary studies suggested that reactive ethoxyacyl radicals generated...

A Pd(OAc)2-catalyzed protocol for decarboxylative arylation of aromatic C−H bond was developed using aryl acylperoxides as inexpensive sources. Substrates containing pyridyl, oxime, and oxazoline groups undergo effectively ortho-selective with excellent functional group tolerance. This should begin by directing-group-assisted cyclopalladation, followed the reaction palladacycle radicals generated in situ thermal decomposition peroxides.

Abstract An efficient palladium‐catalyzed CH acylation with aldehydes using tert ‐butyl hydroperoxide (TBHP) transforms various anilides into synthetically useful 2‐aminobenzophenone derivatives under mild conditions (40 °C, 3 h). The reaction exhibits excellent regioselectivity and functional group tolerance, simple aromatic aldehydes, functionalized aliphatic heteroaromatic are effective coupling partners. is probably initiated by a rate‐limiting electrophilic cyclopalladation ( k H / D...

We report the Ru-catalyzed enantioselective annulation of 1,4,2-dioxazol-5-ones to furnish γ-lactams in up 97% yield and 98% ee via intramolecular carbonylnitrene C—H insertion. By employing chiral diphenylethylene diamine (dpen) as ligands bearing electron-withdrawing arylsulfonyl substituents, reactions occur with remarkable chemo- enantioselectivities; competing Curtius-type rearrangement was largely suppressed. Enantioselective nitrene insertion allylic/propargylic bonds also achieved...

A Rh(III)-catalyzed oxidative [4 + 1] cycloaddition of benzohydroxamic acids and α-diazoesters is achieved to afford benzolactams in up 93% yields. With the N-OAc amido moiety as a directing group, ortho-C-H selectively functionalized catalytic reaction exhibits excellent tolerance different functional substituents. notable rhodacyclic complex isolated structurally characterized, suggesting that C-H/N-H cyclometallation key step cycle.

A NiH-catalyzed thioether-directed cyclometalation strategy is developed to enable remote methylene C–H bond amidation of unactivated alkenes. Due the preference for five-membered nickelacycle formation, chain-walking isomerization initiated by NiH insertion an alkene can be terminated at γ-methylene site from moiety. By employing 2,9-dibutyl-1,10-phenanthroline (L4) as ligand and dioxazolones reagent, occurs γ-C(sp3)–H bonds afford amide products in up 90% yield (>40 examples) with...

ConspectusCatalytic C–N bond cross-coupling reactions have been a subject of fundamental importance in synthetic organic and medicinal chemistry because amides amines are ubiquitous motifs natural products, functional materials, pharmaceuticals. Since the pioneering works Breslow Mansuy on metalloporphyrin-catalyzed direct hydrocarbon amidation using sulfonyliminoiodinane reagents, substantial development has achieved toward practical selective amination protocols. Notably, Du Bois's group...