A5038299644- Advancements in Transdermal Drug Delivery
- Nanoparticles: synthesis and applications
- Contact Dermatitis and Allergies
- Pesticide Exposure and Toxicity
- Animal testing and alternatives
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Immunotoxicology and immune responses
- Dermatology and Skin Diseases
- Bee Products Chemical Analysis
- Skin Protection and Aging
- Carcinogens and Genotoxicity Assessment
- Quantum Dots Synthesis And Properties
- Gold and Silver Nanoparticles Synthesis and Applications
- Essential Oils and Antimicrobial Activity
- Microplastics and Plastic Pollution
- Effects and risks of endocrine disrupting chemicals
- Microfluidic and Bio-sensing Technologies
- Skin and Cellular Biology Research
- 3D Printing in Biomedical Research
- Anodic Oxide Films and Nanostructures
- Fullerene Chemistry and Applications
- Computational Drug Discovery Methods
- Wound Healing and Treatments
- Anesthesia and Neurotoxicity Research
Kansas State University
2014-2024
North Carolina State University
2009-2024
ORCID
2020
Institució Catalana de Recerca i Estudis Avançats
2019-2020
United States Department of State
2015-2016
University of North Carolina at Chapel Hill
2007-2014
UNC/NCSU Joint Department of Biomedical Engineering
2011-2013
University of North Carolina Wilmington
2009
Rice University
2006-2007
North Central State College
2005
Abstract The rapid proliferation of many different engineered nanomaterials (defined as materials designed and produced to have structural features with at least one dimension 100 nanometers or less) presents a dilemma regulators regarding hazard identification. International Life Sciences Institute Research Foundation/Risk Science convened an expert working group develop screening strategy for the identification nanomaterials. report elements rather than detailed testing protocol. Based on...
Skin is the largest organ of body and a potential route exposure to engineered nanomaterials, but permeability skin these nanomaterials unknown. We selected commercially available quantum dots (QD) two core/shell sizes shapes three different surface coatings determine if QD could penetrate intact in size- or coating-dependent manner. Spherical 4.6 nm diameter 565 ellipsoid 12 (major axis) by 6 (minor 655 with neutral (polyethylene glycol), anionic (carboxylic acids) cationic glycol-amine)...
Due to the superior photoemission and photostability characteristics, quantum dots (QD) are novel tools in biological medical applications. However, toxicity mechanism of QD uptake poorly understood. nanoparticles with an emission wavelength 655 nm ellipsoid shape consist a cadmium/selenide core zinc sulfide shell. We have shown that carboxylic acid surface coating were recognized by lipid rafts but not clathrin or caveolae human epidermal keratinocytes (HEKs). internalized into early...
Products using the antimicrobial properties of silver nanoparticles (Ag-nps) may be found in health and consumer products that routinely contact skin.This study was designed to assess potential cytotoxicity Ag-nps human epidermal keratinocytes (HEKs) their inflammatory penetrating into porcine skin vivo.We used eight different this [unwashed/uncoated (20, 50, 80 nm particle diameter), washed/uncoated nm), carbon-coated (25 35 nm)]. Skin dosed topically for 14 consecutive days. HEK viability...
Sunscreens containing titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles (NP) are effective barriers against ultraviolet B (UVB) damage to skin, although little is known about their disposition in UVB-damaged skin. Pigs were exposed UVB that resulted moderate sunburn. For vitro studies, skin flow-through diffusion cells treated 24 h with four sunscreen formulations as follows: 10% coated TiO2 oil/water (o/w), water/oil (w/o), 5% ZnO o/w, uncoated o/w. (rutile, crystallite) primary...
Dermatomed porcine skin was fixed to a flexing device and topically dosed with 33.5 mg·mL-1 of an aqueous solution fullerene-substituted phenylalanine (Baa) derivative nuclear localization peptide sequence (Baa-Lys(FITC)-NLS). Skin flexed for 60 or 90 min left unflexed (control). Confocal microscopy depicted dermal penetration the nanoparticles at 8 h in min, whereas Baa-Lys(FITC)-NLS did not penetrate into dermis until 24 h. TEM analysis revealed fullerene-peptide within intercellular...
The critical barrier for clinical translation of cancer nanomedicine stems from the inefficient delivery nanoparticles (NPs) to target solid tumors. Rapid growth computational power, new machine learning and artificial intelligence (AI) approaches provide tools address this challenge. In study, we established an AI-assisted physiologically based pharmacokinetic (PBPK) model by integrating AI-based quantitative structure-activity relationship (QSAR) with a PBPK simulate tumor-targeted...
In this report we present the findings from a nanotoxicology workshop held 6-7 April 2006 at Woodrow Wilson International Center for Scholars in Washington, DC. Over 2 days, 26 scientists government, academia, industry, and nonprofit organizations addressed two specific questions: what information is needed to understand human health impact of engineered nanoparticles how best obtained? To assess hazards near-term, most participants noted need use existing vivo toxicologic tests because...
This article summarizes a roundtable discussion held at the 2005 Society of Toxicology Annual Meeting in New Orleans, LA. The purpose was to review current challenges and data needs for conducting toxicological safety evaluations nanomaterials, with goals presenting state-of-the science on nanomaterials bringing together scientists representing government, academia, industry identify priorities developing facilitate risk assessments these materials. In this summary, unique physicochemical...
Three‐dimensional microneedle devices were created by femtosecond laser two photon polymerization (2PP) of organically modified ceramic (Ormocer®) hybrid materials. Arrays in‐plane and out‐of‐plane hollow microneedles (microneedle length=800 μm, base diameter=150–300 μm) with various aspect ratios fabricated. The fracture penetration properties the arrays examined using compression load testing. In these studies, penetrated cadaveric porcine adipose tissue without fracture. Human epidermal...
Reactive oxygen species generated by ultraviolet light result in photocarcinogenic and photoaging changes the skin. Antioxidants protect skin from these insults.This study defines formulation characteristics for delivering L-ascorbic acid into to supplement skin's natural antioxidant reservoir.L-ascorbic or its derivatives were applied pig Skin levels of measured determine percutaneous delivery.L-ascorbic must be formulated at pH less than 3.5 enter Maximal concentration optimal absorption...
Carbon nanotube–based nanovectors, especially functionalized nanotubes, have shown potential for therapeutic drug delivery. 6-Aminohexanoic acid–derivatized single-wall carbon nanotubes (AHA-SWNTs) are soluble in aqueous stock solutions over a wide range of physiologically relevant conditions; however, their interactions with cells and biological compatibility has not been explored. Human epidermal keratinocytes (HEKs) were dosed AHA-SWNTs ranging concentration from 0.00000005 to 0.05 mg/ml....