A5100384493- Flavonoids in Medical Research
- Natural product bioactivities and synthesis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular and exercise physiology
- Remote Sensing and Land Use
- Pulmonary Hypertension Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Toxin Mechanisms and Immunotoxins
- Environmental and Agricultural Sciences
- Cardiac Ischemia and Reperfusion
- Aeolian processes and effects
- Cardiovascular Conditions and Treatments
- Geology and Paleoclimatology Research
- Phytochemistry and Biological Activities
- Chromatography in Natural Products
- Congenital heart defects research
- Hemodynamic Monitoring and Therapy
- Advanced Image Fusion Techniques
- Biochemical and Structural Characterization
- Glaucoma and retinal disorders
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Lung Cancer Diagnosis and Treatment
Shandong University of Technology
2019-2024
Shanghai Jiao Tong University
2024
Ningxia University
2023
State Council of the People's Republic of China
2019
Ningbo Medical Center Lihuili Hospital
2015-2019
Shanghai Pulmonary Hospital
2011
Tongji University
2011
Introduction: Staphylococcus aureus ( S. ) is a common cause of mastitis in dairy cows, condition that has significant economic impact. displays quorum sensing (QS) system-controlled virulence characteristics, like biofilm formation, make therapy challenging. In order to effectively combat , one potential technique interfere with sensing. Methods: This study evaluated the effects different Baicalin (BAI) concentrations on growth and isolates, including formation mature clearance. The binding...
As a new vegetation monitoring index, the KNDVI has certain advantages in characterizing evolutionary process of regional desertification. However, there are few reports on desertification based and feature space models. In this study, seven parameters, including kernel normalized difference index (KNDVI) Albedo, were introduced to construct different models for remote-sensing monitoring. The optimal model was determined with measured data; then, spatiotemporal evolution pattern Gulang...
Nonalcoholic fatty liver disease (NAFLD) has become the most common worldwide; thus, a dietary supplement that can restrict hepatic fat accumulation is needed.
Introduction: This study aims to assess the long-term renal prognosis of patients with hypertensive nephropathy (HN) diagnosed through biopsy, utilizing random survival forest (RSF) algorithm. Methods: From December 2010 2022, HN by biopsy in Xijing Hospital were enrolled and randomly divided into training set testing at a ratio 7∶3. The study's composite endpoint was defined as ≥ 50% decline estimated glomerular filtration rate (eGFR), ESRD, or death. RSF Cox regression used establish...
The synthesis and accumulation of collagen play an important role in the formation progression hypoxic pulmonary hypertension. Baicalin has been reported to prevent bleomycin-induced fibrosis. However, baicalin treatment hypertension remains unknown. A disintegrin metalloprotease with thrombospondin type-1 motif (ADAMTS-1) is a secreted enzyme that acts on wide variety extracellular matrix (ECM) substrates associated vascular diseases. In this study, we aimed investigate effects I rats...
Baicalin has a protective effect on hypoxia‐induced pulmonary hypertension in rats, but the mechanism of this remains unclear. Thus, investigating potential was aim present study. Model rats that display hypoxic and cor pulmonale under control conditions were successfully generated. We measured series indicators to observe levels arterial hypertension, arteriole remodeling, right ventricular remodeling. assessed activation p38 mitogen‐activated protein kinase (MAPK) walls tissue homogenates...
Previous studies are mostly conducted based on sparse time series and often ignore the dramatic changes in desertification during year. Utilizing Landsat MODIS data sets from 2000 to 2020, this study applied spatio-temporal fusion algorithm obtain images of area taken at similar times August over past 20 years. The optimal remote sensing monitoring index Gulang County was constructed feature space model, then spatial temporal evolution patterns driving mechanism were revealed by using a...
Global changes have led to significant in soil erosion on the Loess Plateau. Soil leads degradation of land resources and a decline fertility, adversely affecting agricultural production socioeconomic situation. Therefore, revealing spatiotemporal evolution patterns Plateau region investigating influencing factors that contribute are crucial for its management restoration. In this study, RUSLE monthly model Geodetector were utilized reveal trends from 2000 2020 determine dominant different...
Mesenchymal stem cells (MSCs) have exhibited great potential in the therapy of cardiovascular disease. However, application MSCs is hampered by apoptosis, which reduces number host cardiac microenvironment. Ulinastatin (UTI), a broad‑spectrum protease inhibitor that can be purified from human urine, has attracted attention for its protective effects through immunomodulatory and anti‑inflammatory properties. The present study aimed to evaluate UTI on serum deprivation‑induced apoptosis...
Abstract Daptomycin, a lipopeptide comprising an N ‐decanoyl fatty acyl chain and peptide core, is used clinically as antimicrobial agent. The start condensation domain (dptC1) enzyme that catalyzes the lipoinitiation step of daptomycin synthesis. In this study, we integrated enzymology, protein engineering, computer simulation to study substrate selectivity screen mutants with improved activity for decanoyl loading. Through molecular docking simulation, channel protein–protein interaction...
We reported that alpha-ketoglutarate (α-KG) is indispensable for chronic hypoxia (CH)-induced cardiac remodeling, which builds the bridge between metabolic intermediates and remodeling.
Objective The aim of the current study was to determine if slowed exercise oxygen uptake (VO2) kinetics would be accompanied by delayed recovery VO2 in patients with severe chronic obstructive pulmonary disease (COPD). Methods We evaluated 37 COPD and 17 normal people, who had function test(PFT)and cycle ergo meter cardiopulmonary test (CPET) studies maximum tolerance. Gas exchange calculated breath breath.Results MRT τRec for were consistently found longer than controls ( P<0. 010),and...
Objective To better understand the oxygen uptake kinetics during 3 minutes of unloaded exercise cardiopulmonary test (CPET) in patients with severe chronic obstructive pulmonary disease(COPD), to investigate relationship between mean response time (MRT)for consumption(VO2)and capacity, and evaluate usage MRT as one parameters judge functions COPD. Methods We evaluated 41 COPD 30 normal peoples, who had function (PFT)and cycle ergometer CPET studies maximum tolerance. Gas exchange were...