A5046978287- Pulmonary Hypertension Research and Treatments
- Medicinal Plants and Bioactive Compounds
- COVID-19 diagnosis using AI
- Immune Response and Inflammation
- Antifungal resistance and susceptibility
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Fungal Infections and Studies
- Diet, Metabolism, and Disease
- PI3K/AKT/mTOR signaling in cancer
- Dementia and Cognitive Impairment Research
- Adenosine and Purinergic Signaling
- Cancer, Hypoxia, and Metabolism
- Memory and Neural Mechanisms
- Peptidase Inhibition and Analysis
- Brain Tumor Detection and Classification
- Sarcoidosis and Beryllium Toxicity Research
- Flavonoids in Medical Research
- Machine Learning and ELM
- Hemodynamic Monitoring and Therapy
- Autophagy in Disease and Therapy
- Fibroblast Growth Factor Research
- COVID-19 epidemiological studies
- Inflammation biomarkers and pathways
- Immune Cell Function and Interaction
Wenzhou Medical University
2015-2023
First Affiliated Hospital of Wenzhou Medical University
2015-2023
Highlights•Salidroside improves chronic hypoxia-induced pulmonary arterial hypertension.•Salidroside reverses apoptosis resistance in PASMCs.•Salidroside modulates cell via mitochondria-dependent pathway upregulates adenosine A2a receptor expression under hypoxia conditionsAbstractPulmonary hypertension (PAH) is characterized by remodeling mainly due to excess cellular proliferation and of smooth muscle cells (PASMCs). Salidroside, an active ingredient isolated from Rhodiola rosea proposed...
Recent studies have shown that both adenosine monophosphate activated protein kinase (AMPK) and the mammalian target of rapamycin (mTOR) are energy sensors related to autophagy. Our recent reports salidroside can exert protective effects against hypoxia-induced pulmonary arterial smooth muscle cell (PASMC) proliferation apoptosis resistance through AMPK pathway. This study aims explore relationship among AMPK, mTOR ULK1 in PASMCs under hypoxic conditions investigate whether autophagic death...
Curcumin, as a pro-apoptotic agent, is extensively studied to inhibit tumor cell growth of various types. Previous work has demonstrated that curcumin inhibits cancer by targeting multiple signaling transduction and cellular processes. However, the role in regulating bioenergetic processes remains largely unknown.Western blotting qRT-PCR were performed analyze protein mRNA level indicated molecules, respectively. RTCA, CCK-8 assay, nude mice xenograft vivo bioluminescence imaging used...
Baicalin has been reported to have anti-fibrosis effect; however, its mechanism still remains be elucidated. Adenosine A2a receptor (A2aR) is a novel inflammation regulator, and transforming growth factor-β1 (TGF-β1)-induced extracellular signal regulated kinase1/2 (ERK1/2) signaling pathway plays an important role in idiopathic pulmonary fibrosis (IPF). This study was explore the relationship of A2aR TGF-β1-induced ERK1/2 bleomycin (BLM)-induced mice, investigate whether mediate effect on...
Baicalin, an important flavonoid in Scutellaria baicalensis Georgi extracts, exerts a variety of pharmacological effects. In this study, we explored the effects baicalin on chronic hypoxia-induced pulmonary arterial hypertension (PAH) and investigated mechanism underlying these Moreover, examined whether inflammatory response was mediated by A2A receptor (A2AR) stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine type 4 (CXCR4)-induced phosphatidyl inositol-3-kinase (PI3K) signaling vivo....
The synthesis and accumulation of collagen play an important role in the formation progression hypoxic pulmonary hypertension. Baicalin has been reported to prevent bleomycin-induced fibrosis. However, baicalin treatment hypertension remains unknown. A disintegrin metalloprotease with thrombospondin type-1 motif (ADAMTS-1) is a secreted enzyme that acts on wide variety extracellular matrix (ECM) substrates associated vascular diseases. In this study, we aimed investigate effects I rats...
Baicalin has a protective effect on hypoxia‐induced pulmonary hypertension in rats, but the mechanism of this remains unclear. Thus, investigating potential was aim present study. Model rats that display hypoxic and cor pulmonale under control conditions were successfully generated. We measured series indicators to observe levels arterial hypertension, arteriole remodeling, right ventricular remodeling. assessed activation p38 mitogen‐activated protein kinase (MAPK) walls tissue homogenates...
This paper has proposed an effective intelligent prediction model that can well discriminate and specify the severity of Coronavirus Disease 2019 (COVID-19) infection in clinical diagnosis provide a criterion for clinicians to weigh scientific rational medical decision-making. With indicators as age gender patients 26 blood routine indexes, framework COVID-19 is based on machine learning techniques. The consists mainly random forest support vector (SVM) optimized by slime mould algorithm...
Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disease without clear mechanism or drugs for treatment. Therefore, it crucial to reveal the underlying molecular and identify potential PAH. In this study, we first integrated three human lung tissue datasets (GSE113439, GSE53408, GSE117261) from GEO. A total of 151 differentially expressed genes (DEGs) were screened, followed by KEGG GO enrichment analyses PPI network construction. Five hub (CSF3R, NT5E, ANGPT2, FGF7,...
Vascular endothelial apoptosis and dysfunction have a crucial role in triggering pathological vascular remodeling of hypoxia‑induced pulmonary arterial hypertension (PAH). Fibroblast growth factor (FGF)21, an endocrine regulator, has recently been reported to protect cardiac cells from damage suppress inflammatory responses. In addition, FGF21 is be involved endoplasmic reticulum stress (ERS). Previous studies suggested that ERS participates the development PAH, attenuation could effective...
Synergistic therapeutic nanomedicine with great biosafety was regarded as a promising strategy for cancer therapy in clinic. Due to the drug resistance and insufficient performance of chemotherapy, response rate non-small cell lung is limited. As another effective against tumor, ferroptosis may enhance sensitivity chemotherapy. Herein, we reported biomimetic iron metal–organic framework (Fe-MOF) responding intracellular environment accelerate tumor death by inducing apoptosis cells. We...
Pulmonary hypertension (PH) is a chronic progressive disease with limited treatment options. The exact etiology and pathogenesis of PH remain to be elucidated, however there novel evidence that implicates abnormal endothelial cells (ECs) apoptosis dysfunction ECs involved in the initiation PH. Asiaticoside (AS) saponin monomer extracted from medicinal plant called Centella asiatica, which had preventing effect hypoxia‑induced pulmonary (hypoxic PH) by blocking transforming growth...
The present study aimed to investigate the therapeutic effect of monoammonium glycyrrhizinate (MAG) on lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice and possible mechanism. Acute was BALB/c by intratracheal instillation LPS, MAG injected intraperitoneally 1 h prior LPS administration. After ALI, histopathology lungs, wet/dry weight ratio, protein concentration, inflammatory cells bronchoalveolar lavage fluid (BALF) were determined. levels tumor necrosis factor-α (TNF-α)...
Little is known about the longitudinal association of cigarette smoking with Alzheimer's Disease (AD) related markers in subjects mild cognitive impairment (MCI). In this study, we aimed to examine effect a history on change global cognition, verbal memory, functional performance, hippocampal volume, entorhinal cortex brain glucose metabolism, and CSF AD pathologies over time MCI subjects. At baseline, there were 870 MCI, including 618 non-smokers (no smoking) 252 smokers (any lifetime...