A5100622912- Topic Modeling
- Laser Design and Applications
- Laser Material Processing Techniques
- Corneal surgery and disorders
- Speech and dialogue systems
- Advanced Glycation End Products research
- Cryptography and Data Security
- Connexins and lens biology
- Speech Recognition and Synthesis
- Natural Language Processing Techniques
- SARS-CoV-2 and COVID-19 Research
- Food composition and properties
- Medical Imaging Techniques and Applications
- Corneal Surgery and Treatments
- Metaheuristic Optimization Algorithms Research
- Solid State Laser Technologies
- Software Engineering Research
- Spectroscopy and Laser Applications
- Cassava research and cyanide
- Cannabis and Cannabinoid Research
- Advanced Fiber Optic Sensors
- Aldose Reductase and Taurine
- Semiconductor Lasers and Optical Devices
- Software Reliability and Analysis Research
- Complexity and Algorithms in Graphs
Southern Medical University
2025
Guangxi University
2025
Zhejiang University
2005-2024
Huazhong Agricultural University
2023-2024
University of Science and Technology of China
2015-2024
Third People's Hospital of Hangzhou
2024
Qufu Normal University
2024
Zhejiang Pharmaceutical College
2019-2024
Guangdong University of Technology
2024
South China Agricultural University
2023
Multi-modal large language models are regarded as a crucial step towards Artificial General Intelligence (AGI) and have garnered significant interest with the emergence of ChatGPT. However, current speech-language typically adopt cascade paradigm, preventing inter-modal knowledge transfer. In this paper, we propose SpeechGPT, model intrinsic cross-modal conversational abilities, capable perceiving generating multi-modal content. With discrete speech representations, construct SpeechInstruct,...
In dialogue systems, utterances with similar semantics may have distinctive emotions under different contexts. Therefore, modeling long-range contextual emotional relationships speaker dependency plays a crucial part in emotion recognition. Meanwhile, distinguishing the categories is non-trivial since they usually semantically sentiments. To this end, we adopt supervised contrastive learning to make mutually exclusive identify better. utilize an auxiliary response generation task enhance...
Human corneal endothelial cells (HCEnCs) form a monolayer of hexagonal whose main function is to maintain clarity by regulating hydration. HCEnCs are derived from neural crest and arrested in the post-mitotic state. Thus cell loss due aging or disorders leads edema blindness–the leading indication for transplantation. Here we show existence morphologically distinct subpopulations that interspersed among primary exhibit enhanced self-renewal competence lack phenotypic signs cellular...
Corneal endothelium (CE) is among the most metabolically active tissues in body. This elevated metabolic rate helps CE maintain corneal transparency by its ion and fluid transport properties, which when disrupted, leads to visual impairment. Here we demonstrate that glutamine catabolism (glutaminolysis) through TCA cycle generates a large fraction of ATP needed function, this glutaminolysis severely disrupted cells deficient NH3:H+ cotransporter Solute Carrier Family 4 Member 11 (SLC4A11)....
SLC4A11 is a NH3 sensitive membrane transporter with H+ channel-like properties that facilitates Glutamine catabolism in Human and Mouse corneal endothelium (CE). Loss of activity induces oxidative stress cell death, resulting Congenital Hereditary Endothelial Dystrophy (CHED) edema vision loss. However, the mechanism by which prevents ROS production protects CE unknown. Here we demonstrate localized to inner mitochondrial transfected PS120 fibroblasts, where it acts as an NH3-sensitive...
Objectives To summarize development processes and research hotspots of infrared imaging technology on acupuncture to provide new insights for researchers in future studies. Methods Publications regarding from 2008 2023 were downloaded the Web Science Core Collection (WoSCC). VOSviewer 1.6.19, CiteSpace 6.2.R4, Scimago Graphica, Microsoft Excel software used bibliometric analyses. The main analyses include collaboration between countries, institutions, authors, journals, as well keywords...
In this study, the metabolite profiling of three different parts Crocus sativus L. was measured by using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTof-MS/MS). Multivariate statistical analysis used to distinguish among samples from parts. A total 54 compounds were identified in tepals, stigmas and stamens UPLC-QTof-MS/MS. The results stated that chemical characteristics saffron obviously diverse terms flower. Through analysis, coniferin...
This paper has proposed an effective intelligent prediction model that can well discriminate and specify the severity of Coronavirus Disease 2019 (COVID-19) infection in clinical diagnosis provide a criterion for clinicians to weigh scientific rational medical decision-making. With indicators as age gender patients 26 blood routine indexes, framework COVID-19 is based on machine learning techniques. The consists mainly random forest support vector (SVM) optimized by slime mould algorithm...
Current speech large language models build upon discrete representations, which can be categorized into semantic tokens and acoustic tokens. However, existing are not specifically designed for modeling. To assess the suitability of building models, we established first benchmark, SLMTokBench. Our results indicate that neither nor ideal this purpose. Therefore, propose SpeechTokenizer, a unified tokenizer models. SpeechTokenizer adopts Encoder-Decoder architecture with residual vector...
Angiotensin converting enzyme (ACE) inhibitory peptides are biologically active that play a very important role in blood pressure regulation. In previous experiments, we obtained an ACE peptide Val-Leu-Pro-Val-Pro (VLPVP) by DNA recombinant technology. The purpose of this study was to examine the bidirectional transport VLPVP using human intestinal Caco-2 monolayers. permeability coefficient ( P app) values over 4-8 mmol/L ranged from 7.44 x 10(-8) 1.35 10(-6) cm/s for apical (AP)...
Traditional soaking method takes days to remove cassava cyanide. Ten minutes of ultrasonic pretreatment (UPT) was found be a new effective eliminate both cyanogenic glycosides and hydrogen cyanide in cassava. Here, the parameters UPT were optimized underlying mechanisms investigated. 40.36% 24.95% juice eliminated under 10 min (45℃, 81 W). before boiling enhanced total elimination 41.94%. The degradation patterns different. Ultrasound directly indirectly degraded through promoting enzymatic...
The problem of rapid decline in egg production performance and poor quality is a key obstacle to improving the economic benefits laying hens. Garcinol an antioxidant polyphenol plant extract that has multiple physiological functions. Diets with appropriate amount garcinol might be able improve traits health late Therefore, this study was conducted evaluate utilization A total 400 healthy 59-week-old Tingfen No.6 hens were randomly allocated into four dietary treatment groups fed basal diet...
Cannabinoid CB1 receptors are found in abundance the vertebrate eye, with most tissue types expressing this receptor. However, function of corneal epithelial cells (CECs) is poorly understood. Interestingly, corneas knockout mice heal more slowly after injury via a mechanism proposed to involve protein kinase B (Akt) activation, chemokinesis, and cell proliferation. The current study examined role cannabinoids CEC migration greater detail.We determined healing. We consequences their...
The objective of this paper is to determine a breakdown mechanism transition with increasing vacuum gaps. A rod-plane gap was designed in interrupter. current and voltage conditioning process performed order. Two shots ac power frequency were applied at different gaps until occurred, the 1.0 mm, 0.8 mm 0.5 respectively. field emission simultaneously measured. Whether fitted Fowler-Nordheim theory used distinguish induced particles breakdown. results showed that there no between two spacing,...
Purpose: Confirm that the corneal endothelial pump uses a lactate-coupled water efflux mechanism. Methods: Corneal thickness, lactate efflux, and stromal [lactate] were measured in de-epithelialized swollen nonswollen ex vivo-mounted rabbit corneas perfused with bicarbonate-rich bicarbonate-free Ringers, ouabain, or acetazolamide to determine if relationships among these parameters similar previous data using intact corneas. The role of barrier function was tested by perfusion calcium-free...
Abstract Infection by bacteria leads to tissue damage and inflammation, which need be tightly controlled host mechanisms avoid deleterious consequences. It is previously reported that TMEM16F, a calcium‐activated lipid scramblase expressed in various immune cell types including T cells neutrophils, critical for the control of infection bacterium Listeria monocytogenes ( Lm ) vivo. This function correlated with capacity TMEM16F repair plasma membrane (PM) induced vitro, toxin listeriolysin O...