A5100625053- Salivary Gland Disorders and Functions
- Salivary Gland Tumors Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Pulmonary Hypertension Research and Treatments
- Gut microbiota and health
- Autoimmune and Inflammatory Disorders Research
- Circular RNAs in diseases
- Systemic Lupus Erythematosus Research
- Oral microbiology and periodontitis research
- Chemokine receptors and signaling
- Urinary Tract Infections Management
- Rheumatoid Arthritis Research and Therapies
- Marine Bivalve and Aquaculture Studies
- Galectins and Cancer Biology
- Diabetes and associated disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- HIV/AIDS oral health manifestations
- Spondyloarthritis Studies and Treatments
- Bladder and Urothelial Cancer Treatments
- Crustacean biology and ecology
- IL-33, ST2, and ILC Pathways
- Genomics and Rare Diseases
- Psoriasis: Treatment and Pathogenesis
- Nitric Oxide and Endothelin Effects
- Skin Diseases and Diabetes
Shanghai Changzheng Hospital
2021-2024
Wenzhou Medical University
2013-2024
First Affiliated Hospital of Wenzhou Medical University
2015-2024
Second Military Medical University
2021-2022
Taizhou Second People's Hospital
2018
Yangzhou University
2018
Hainan University
2009-2012
China Medical University
2012
Shaanxi Normal University
2007
We sought to test the hypothesis that Polygenic Risk Scores (PRSs) have strong capacity discriminate cases of ankylosing spondylitis (AS) from healthy controls and individuals in community with chronic back pain.PRSs were developed validated European East Asian ethnicity, using data genome-wide association studies 15 585 AS 20 452 controls. The discriminatory values PRSs these populations compared other widely used diagnostic tests, including C-reactive protein (CRP), HLA-B27 sacroiliac...
The human microbiome plays an important role in autoimmune diseases. However, there is limited knowledge regarding the microbiota individuals with primary Sjögren's syndrome (pSS). Here, we perform 16S ribosomal RNA gene sequencing of fecal, oral, and vaginal samples from a cohort 133 pSS, 56 non-pSS, 40 healthy control (HC) individuals. Dysbiosis gut, evident patients oral demonstrate greatest extent microbial variation. Multiple key indicator bacteria clinical characteristics are...
Abstract Asiaticoside (AS) has been reported to have protective effect on pulmonary fibrosis (PF). In this study, we aimed explore the potential mechanism of therapeutic role AS and its relationship with A2AR in PF. Adenosine 2A receptor gene knockout (A2AR −/− ) mice wild‐type (WT) were used establish bleomycin (BLM)‐induced PF models then treated (50 mg/kg/d). Pulmonary inflammation observed model much higher severity than that WT significantly alleviated lung fibrosis; however, it was...
This study aims to characterize the expression profiles of circRNAs in primary Sjogren's Syndrome (pSS) and examine potential noninvasive circular RNAs (circRNAs) as biomarkers pSS.We performed RNA sequencing minor salivary gland (MSG) biopsies from four pSS non-pSS individuals (subjects undergoing MSG but not meeting 2012 or 2016 ACR classification criteria for SS). Differentially expressed were identified by DESeq2, confirmed quantitative real-time PCR MSGs well plasma exosomes 37 14...
Abstract Objective To investigate distinct features of renal involvement in patients with primary Sjögren’s syndrome (pSS) and to identify potential factors associated involvement. Methods Four hundred thrity‐four pSS from the Rheumatology Department First Affiliated Hospital Wenzhou Medical University 2013 2017 were included a cross‐sectional study. Patients compared their age‐ gender‐matched controls (pSS without involvement). Demographic, clinical, histological, nephritic, immunological...
Pulmonary hypertension (PH) is a chronic progressive disease with limited treatment options. The exact etiology and pathogenesis of PH remain to be elucidated, however there novel evidence that implicates abnormal endothelial cells (ECs) apoptosis dysfunction ECs involved in the initiation PH. Asiaticoside (AS) saponin monomer extracted from medicinal plant called Centella asiatica, which had preventing effect hypoxia‑induced pulmonary (hypoxic PH) by blocking transforming growth...
Primary Sjögren’s syndrome (pSS) is a chronic systemic autoimmune disease characterized by exocrine gland damage and extraglandular involvements. To identify potential biomarkers for the early detection of pSS to further investigate roles in progression pSS, our previous RNA sequencing data four microarray salivary glands (SGs) were combined integrative transcriptome analysis between non-pSS. Differential gene expression analysis, co-expression network pathway conducted detect hub genes,...
Abstract Background Pulmonary arterial hypertension (PAH) is a life-threatening condition. The aim of this study was to explore potential crucial genes and pathways associated with PAH based on integrative analyses gene expression shed light the identification biomarker for PAH. Methods Gene profile pulmonary tissues from 27 patients 22 normal controls were downloaded public database (GSE53408 GSE113439). After differentially expressed (DEGs), hub identified comprehensive evaluation...
BACKGROUND Gremlin has been reported to be up-regulated in glomerular mesangial cells diabetic nephropathy (DN). However, the regulation of gremlin podocytes is still rarely reported. This study aimed investigate underlying mechanisms by which mediates pathogenesis DN via transforming growth factor-β (TGF-β) signaling pathways. MATERIAL AND METHODS Lentiviral and RNAi transfection were performed increase decrease expression high-glucose conditions. Expression at mRNA protein level was...
Primary Sjögren's syndrome (pSS) is a common chronic autoimmune disease characterized by high prevalence of autoantibodies and lymphocyte-mediated exocrine gland damage. To enhance our understanding the mechanisms underlying progression to discover potential biomarkers for early diagnosis pSS, we applied RNA sequencing compare gene expression patterns in minor salivary glands between pSS patients non-pSS. A total 293 differentially expressed genes (DEGs) were detected vs. non-pSS (P 2). Of...
Abstract Objective To determine the upregulation of IL-21-inducible genes in minor salivary glands (MSGs) 28 primary SS (pSS) patients and 12 non-pSS subjects correlate it with disease characteristics. Methods RNA sequencing was utilized to compare expression MSGs between pSS subjects. The subgroups were characterized according IL-21 score calculated by seven genes. Furthermore, characteristics transcripts implicated hypoxia interferon signalling assessed two subgroups. Results We observed...
This study was aimed to evaluate the role of B-cell epitopes Epstein-Barr virus (EBV) Early antigen protein D (EA), envelope glycoprotein GP340/membrane (MA), latent membrane (LMP)-1, and LMP-2A in systemic lupus erythematosus (SLE). were predicted by analyzing secondary structure, transmembrane domains, surface properties, homological comparison. 60 female mice randomized equally into 12 groups: 1-10 groups immunized epitope peptides (EPs) 1-10, respectively, while 11 PBS Keyhole limpet...
Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DNMs) will aid our understanding of neurobiological and basis ID. In this study, we identify 63 high-confidence ID genes with q-values < 0.1 four background DNM rates coding data sets from multiple sequencing cohorts. Bioinformatic annotations revealed a higher burden these in FMRP targets CHD8 targets, show evolutionary constraint against functional variation. Moreover, risk were preferentially...
Mononuclear cell infiltration and type I interferon (IFN) system activation play an important role in primary Sjögren's syndrome (SS). We undertook this study to investigate the mechanism of poly(ADP-ribose) polymerase family member 9 (PARP-9) on mononuclear triggered by IFN.A proteomic was conducted peripheral blood cells from patients with SS (n = 30) healthy controls determine differentially expressed proteins (DEPs) (P < 0.05; fold change >1.20). Labial salivary glands (LSGs) were...
Major salivary gland ultrasonography (SGUS) is increasingly being recognized as having critical roles in differentiating primary Sjögren's syndrome (pSS) from other connective tissue disorders. Contrast-enhanced (CEUS) has been reported to evaluate microvascularity of lesions different tissues with objective angiographic index, eliminating the observer-dependent defect ultrasonography. However, there are few relevant studies concentrating on application CEUS diagnosis and assessment for pSS,...