A5001930245- Mechanical Circulatory Support Devices
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Pregnancy-related medical research
- Spine and Intervertebral Disc Pathology
- Vasculitis and related conditions
- Musculoskeletal pain and rehabilitation
- Transplantation: Methods and Outcomes
- Organ and Tissue Transplantation Research
- Enterobacteriaceae and Cronobacter Research
- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Climate Change and Health Impacts
- Receptor Mechanisms and Signaling
- Long-Term Effects of COVID-19
- Cardiovascular Function and Risk Factors
- Vascular Procedures and Complications
- Microplastics and Plastic Pollution
- Inflammasome and immune disorders
- Respiratory Support and Mechanisms
Second Affiliated Hospital of Zhejiang University
2024
Henan Cancer Hospital
2024
Zhengzhou University
2024
Shanghai Chest Hospital
2009-2023
Shanghai Jiao Tong University
2009-2023
University of Louisville
2020
The First Affiliated Hospital, Sun Yat-sen University
2020
Zhongshan Hospital
2020
Fudan University
2020
Sun Yat-sen University
2020
Severe cases of coronavirus disease 2019 (COVID-19) cannot be adequately managed with mechanical ventilation alone. The role and outcome extracorporeal membrane oxygenation (ECMO) in the management COVID-19 is currently unclear. Eight patients have received ECMO support Shanghai seven venovenous (VV) one veno arterial (VA) during cardiopulmonary resuscitation. As March 25, 2020, four died (50% mortality), three (37.5%) were successfully weaned off after 22, 40, 47 days support, respectively,...
Estrogenic modulation of pain is an exceedingly complex phenomenon. However, whether estrogen involved in discogenic low back still remains unclear. Here, immunoreactivity staining technique was used to examine the expression level receptors (ERα and ERβ) a related neuropeptide, Substance P lumbar intervertebral discs analyze relationship between ERs P. Nucleus pulposus tissues 23 elderly female patients were harvested during spinal surgeries made detect ERα, ERβ The colocalization...
Extracorporeal membrane oxygenation (ECMO) was developed as a supportive therapy to treat severe respiratory failure. When conventional mechanical ventilation has failed or when there is not enough time the pathology, ECMO potential sustain life. In this report, successful use of support an adult patient with antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitides complicated by failure caused diffuse alveolar hemorrhage will be discussed.
Abstract Background Hyperlactatemia is associated with a poor prognosis in cardiac surgery patients. This study explored the impact of target blood pressure management during cardiopulmonary bypass (CPB) on lactate levels after surgery. Methods Adult patients undergoing valve between 20/1/2020 and 30/6/2020 at Shanghai Chest Hospital were enrolled. The randomized into low mean arterial (L-MAP) group (target MAP 50 60 mmHg) or high (H-MAP) 70 80 mmHg), n = 20 for each. Norepinephrine was...
Introduction: The superiority of pulsatile perfusion during cardiopulmonary bypass remains controversial. We analyzed the frequency-domain characteristics and organ protection nonpulsatile flow in adult patients with valvular disease. Methods: EEP SHE were used to calculate blood energy 60 patients. Fast Fourier Transform was employed analyze power spectral density ratio (Rvpd) energy. Changes endothelin-1, nitric oxide, interleukin-6,10, tumor necrotic factor, S100β, NSE, urinary...
Peptide-based immunotherapy strategies appear promising as an approach to successfully induce antitumor immune response and prolong survival in patients with various cancers. Protein antigens their specific epitopes are formulation targets for anti-tumor vaccines. Bioinformatical approaches predict major histocompatibility complex binding peptides can facilitate the resource-consuming effort of T cell epitope identification. Proliferating nuclear antigen including Ki-67 PCNA, associated...
Background: The study was conducted to assess the resistance capacity of quinolone against Shigella flexneri , and investigate involved mechanism. data were collected from Jiangsu Province, China in 2016. Methods: number 81 S. obtained 12 cities Province during Slide agglutination taken for serotyping, susceptibility test identified by disc diffusion method. PCR aimed amplify resistance-determining region ( QRDR ) genes screen plasmid-mediated (PMQR) determinants. Chromosomal mutation...
The aim of the present study was to evaluate efficacy and safety Shenfu injection (SFI) in prevention contrast-induced acute kidney injury (CI-AKI) coronary syndrome (ACS) patients undergoing percutaneous intervention (PCI). A single-center prospective randomized controlled trial performed 148 ACS PCI were divided randomly into control (n=74; receiving only 0.9% sodium chloride solution for routine hydration) based upon hydration SFI) groups. Serum creatinine (Scr), blood urea nitrogen...
Objective: To investigate the safety and myocardial protective effect of del Nido cardioplegia in coronary artery bypass grafting combined with heart valve replacement adults. Methods: From April 2018 to 2019, 84 patients undergoing under cardiopulmonary (CPB) Second Affiliated Hospital Nantong University Shanghai Chest were selected, divided into (n=44) group Thomas (n=40) using a random number table. The concentration troponin was measured before anesthesia induction 2, 12 24 hours after...
To analyze the reason and treatment of complications 61 cases extracorporeal membrane oxygenation (ECMO) in order to improve survival rate ECMO treatment.ECMO records from January 2007 December 2014 Shanghai Chest Hospital were investigated retrospectively focusing on complications. There included 43 male 18 female patients, age 3 66 years. Indications for post-operative low cardiac output, viral myocarditis, bridge heart transplantation, acute respiratory distress syndrome myocardial...
To investigate a quantitative method for using radial artery pulse waveforms to assess the effect of pulsatile flow during cardiopulmonary bypass (CPB).A total 34 adults with heart disease who underwent open-heart surgery between April 2010 and January 2011 were randomized into perfusion group (n = 17) non-pulsatile 17). Radial arterial patients observed compared before CDB.No waveform could be detected at patients' in both groups when aorta was cross-clamped. Pulse artery, but not CPB....
Background: Postoperative pulmonary dysfunction (PPD) is a common complication observed in patients after cardiac surgery with cardiopulmonary bypass (CPB). The underlying mechanism regulating lung injury CPB unclear. However, since the involvement of regulatory T (Treg) cells and helper 17 (Th17) immune responses has been well established, this study, we investigated contribution these lymphocyte subsets to development PPD CPB. Methods: Fifty-six rheumatic heart disease (RHD) patients’...
To the Editor: We would like to share our opinions regarding concerns that extracorporeal membrane oxygenation (ECMO) may itself aggravate systemic inflammatory response in coronavirus disease 2019 (COVID-19) patients as raised by Dr. Angouras recently published clinical experience.1 Although ECMO technology evolved from cardiopulmonary bypass (CPB) during cardiovascular surgery, research has demonstrated degree of is quite different and much less compared with CPB because a closed...
Objective To evaluate the possibility of radial artery pressure and waveform as a convenient definition pulsatile flow effect perfusion during cardiopulmonary bypass (CPB) procedures.Methods From March 2008 to December,Eighty patients underwent open heart surgery were randomly divided into group (P,n=45) nonpulsatile (NP,n=35).Monitored by waveform,the low was applied from point aortic cross-clamp until its release in P group.A whose revealed double peak or single (＞30 mm Hg,1 Hg=0.133 kPa)...
This study aimed to investigate the blood protective effect of autologous platelet-rich plasma in aortic root reconstruction under longtime cardiopulmonary bypass.
Objective To identify the HLA-A2-restricted CTL epitopes encoded by antigen segment of Ki-67 for preparation tumor vaccines. Methods Two epitope prediction databases ( BIMAS and SYFPEITHI) were used to predict Ki-67, 7 peptides synthesized as candi-dates. The was evaluated peptide-binding test. ELISPOT inspect IFN-γ secre-ted CTLs in order reflect immunogenicity peptides. Results purities synthetic pep-tides positive control peptide all above 95%. Peptide-binding test displayed that...
：Objective To identifythe HLA-A2-restricted cytotoxic lymphocyte (CTL) epitopes encoded by proliferating cellnuclear antigen(PCNA)for preparation of tumor vaccines.Methods Combined with two epitopeprediction databases,BIMAS and SYFPEITHI databases,to predict the PCNA andsynthesized eight peptides as candidates.The peptide-binding assay Was used todetermine affinity Human leukocyte antigenA2(HLA-A2)molecule.ELISPOT was to inspect Interferon-γ(IFN-γ)secreted CTLs in order reflect...
Abstract Background：Hyperlactacidemia seriously affects the prognosis of cardiac surgery patients. This study was to explore impact target blood pressure management during cardiopulmonary bypass (CPB) on lactate level after surgery. Methods: Enrolled in this were patients≧ 18 years who scheduled for valve between January 1, 2020 and June 30, at Shanghai Chest Hospital. The enrolled patients randomized into a low mean arterial (L-MAP) group (target MAP 50-60mmHg) high (H-MAP) 70-80 mmHg)....