A5101487087- Spine and Intervertebral Disc Pathology
- Aortic Disease and Treatment Approaches
- Cervical and Thoracic Myelopathy
- Cardiac Arrest and Resuscitation
- Cardiac and Coronary Surgery Techniques
- Spinal Fractures and Fixation Techniques
- Aortic aneurysm repair treatments
- Congenital Heart Disease Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Musculoskeletal pain and rehabilitation
- Cardiac Ischemia and Reperfusion
- Trauma Management and Diagnosis
- Mechanical Circulatory Support Devices
- Acute Kidney Injury Research
- Pulmonary Hypertension Research and Treatments
- Spinal Cord Injury Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Nerve Injury and Rehabilitation
- Blood transfusion and management
- Coronary Artery Anomalies
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular and Diving-Related Complications
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Magnesium in Health and Disease
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Shanghai Tenth People's Hospital
2020-2024
Tongji University
2020-2024
Shanghai Jiao Tong University
2000-2022
Peking Union Medical College Hospital
2022
Shanghai First People's Hospital
2013-2022
State Key Laboratory of Cardiovascular Disease
2016-2019
John Wiley & Sons (United Kingdom)
2018
Hudson Institute
2018
Renji Hospital
2015-2017
Body mass index (BMI), waist circumference (WC), visceral adiposity (VAI), triglyceride glucose (TyG), TyG-BMI, and TyG-WC have been reported as markers of insulin resistance or type 2 diabetes mellitus (T2DM). However, little is known about the associations between aforementioned risk prediabetes in first-degree relatives (FDRs) T2DM patients. 1544 FDRs patients (635 men 909 women) were enrolled initial cross-sectional study all them finished corresponding examinations. Logistic regression...
Abstract Background Mechanical stress plays a crucial role in the pathogenesis of intervertebral disc degeneration (IVDD). The mechanosensitive Piezo1 ion channel can sense changes mechanical and convert signals into chemical signals. This study aims to investigate effect on stress-induced IVDD explore possible mechanism. Methods expression collagen II immunohistochemical staining, cervical curvature, stiffness nucleus pulpous (NP) were performed normal degenerated human discs. In...
The purpose of this study was to compare the clinical outcomes and radiological changes 3- 4-level anterior cervical diskectomy fusion with stand-alone anchored spacers traditional plates. A total 51 consecutive patients spondylotic myelopathy who underwent or were divided into 2 groups: group (n=23) received B (n=28) an plate. Mean follow-up 14.6 months. Solid achieved in all at final follow-up. No significant difference existed between multilevel implants plate achieving symptomatic...
Objectives Cervical disc arthroplasty (CDA) with Discover prosthesis or anterior cervical discectomy and fusion (ACDF) Zero-P cage has been widely used in the treatment of spondylotic myelopathy (CSM). However, little is known about comparison 2 zero-profile implants single-level CSM. The aim was to compare clinical outcomes radiographic parameters CDA ACDF for Methods A total 128 consecutive patients who underwent 1-level CSM between September 2009 December 2012 were included this study....
The goal was to investigate the prevalence of acute kidney injury (AKI) after total arch replacement with frozen elephant trunk procedure, which achieved by antegrade cerebral perfusion and moderate hypothermic circulatory arrest (MHCA) or deep (DHCA) among patients type A aortic dissection.Overall, 627 adult dissection who underwent from January 2013 until December 2016 at Fuwai Hospital were divided into DHCA (14.1-20.0°C) MHCA (20.1-28.0°C) groups. Postoperative AKI as primary outcome...
BACKGROUND: Acute kidney injury is a common complication after open total aortic arch replacement but lacks effective preventive strategies. Remote ischemic preconditioning has controversial results of its benefit to the and may perform better in high-risk patients acute injury. We investigated whether remote would prevent postoperative replacement. METHODS: enrolled 130 scheduled for randomized them receive either (4 cycles 5-minute right upper limb ischemia reperfusion) or sham pseudo...
Estrogenic modulation of pain is an exceedingly complex phenomenon. However, whether estrogen involved in discogenic low back still remains unclear. Here, immunoreactivity staining technique was used to examine the expression level receptors (ERα and ERβ) a related neuropeptide, Substance P lumbar intervertebral discs analyze relationship between ERs P. Nucleus pulposus tissues 23 elderly female patients were harvested during spinal surgeries made detect ERα, ERβ The colocalization...
This cohort study aims to retrospectively investigate the incidence of severe systemic inflammatory response syndrome (sSIRS) in patients following total aortic arch replacement (TAR) under deep hypothermic circulatory arrest (DHCA) with selective cerebral perfusion and its effect on clinical outcomes.All who underwent TAR DHCA were consecutively enrolled from January 2013 until December 2015 at our institute. sSIRS was diagnosed between 12 48 h postoperatively if met all four criteria SIRS...
Introduction Dysmagnesemia has been demonstrated to be involved in the pathophysiology of kidney diseases and is common cardiac surgical patients. It remains unknown whether changes serum magnesium after surgery affect AKI. We aimed investigate association early postoperative with surgery-associated AKI adults.Methods conducted a multicenter retrospective cohort study involving patients who underwent eICU Collaborative Research Database between 2014 2015. within 7 days was defined using both...
Endotracheal re-intubation following coronary artery bypass grafting (CABG) is often associated with significant morbidity and mortality. However, few reports have focused on the independent risk factors for CABG. This study aimed to evaluate CABG.The pre-, intra-, post-operative materials in patients who had selective isolated CABG performed them from January 2004 July 2012 our hospital were analyzed retrospectively. Unvariate analysis logistic regression used analyze factor of...
We aimed to investigate the relationship between increased free fatty acid (FFA) level and early postoperative hypoxemia after coronary artery bypass grafting (CABG) with cardiopulmonary (CPB). Ninety-eight consecutive patients undergoing CABG were enrolled. Early was defined as lowest of ratio arterial oxygen tension (PaO2) inspired fraction (FiO2) ≤ 200 mm Hg within 24 h without pleural effusion pneumothorax. The 26 perioperative factors, serum levels FFA inflammatory cytokines...
Objectives: Skeletal development is a complex process.Little known about the different response of limb or spine growth plate chondrocytes (LGP SGP) to estrogen level and role receptor (ER) during postnatal stage. Methods:LGP SGP were isolated from 50 one-week mice treated with concentrations 17β-estradiol.Cell viability was measured by cell counting kit-8 (CCK-8).The expression collagen II X evaluated real-time PCR Western blotting.Then, LGP chondrocyte after without estradiol specific ER...
Lipid abnormality and obesity have been proposed to be associated with lumbar disc degeneration, but little is known about the effect of 'lipid healthy obese' (LH-O) abnormal not (LA-NO) phenotypes on degeneration in Chinese. The study aims determine impact distinction LH-O LA-NO Chinese, identify association related factors risk degeneration.A total 678 individuals were included magnetic resonance imaging, serum lipid levels anthropometric measurements. Obesity was defined basis body mass...
Autophagy, a macromolecular degradation process, plays pivotal role in cell differentiation and survival. This study was designed to investigate the of autophagy osteogenic ligamentum fibroblasts. Rat fibroblasts were isolated from posterior longitudinal ligament cultured induction medium. Ultrastructural analysis, immunofluorescence assay, western blot, flow cytometry, lysosomal activity assessment performed determine presence cells. The mineralization deposit gene expressions evaluated...
Acute kidney injury (AKI) is a major postoperative morbidity of patients undergoing cardiac surgery and has negative effect on prognosis. The outcomes after pulmonary endarterectomy (PEA) have not yet been reported; However, several perioperative characteristics PEA may induce AKI. objective our study was to identify the incidence risk factors for AKI its association with short-term outcomes.This single-center, retrospective, observational, cohort study. Assessments diagnosis executed based...