A5100414661- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Cardiovascular and Diving-Related Complications
- Renal and related cancers
- Mechanical and Optical Resonators
- COVID-19 Clinical Research Studies
- Quantum Information and Cryptography
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Corneal Surgery and Treatments
- Acute Kidney Injury Research
- Diet and metabolism studies
- Cardiovascular Conditions and Treatments
- Clinical Nutrition and Gastroenterology
- Cardiac and Coronary Surgery Techniques
- Nutrition and Health in Aging
- Reproductive System and Pregnancy
- Cardiac Arrest and Resuscitation
- Dermatological and COVID-19 studies
- Birth, Development, and Health
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Respiratory Support and Mechanisms
Shanghai Jiao Tong University
2013-2023
Ruijin Hospital
2012-2023
North China University of Science and Technology Affiliated Hospital
2022
Shanghai Children's Hospital
2018-2020
Tianjin Medical University General Hospital
2018
Shanghai First People's Hospital
2015
Kidney aging leads to an increased incidence of end-stage renal disease (ESRD) in the elderly, and is a complex biological process controlled by signaling pathways transcription factors. Podocyte senescence plays central role injury resulting from kidney aging. Here, we demonstrated critical C/EBPα podocyte generating genetically modified mouse model chronological which was selectively deleted podocytes overexpressing cultured podocytes, premature induced treatment with adriamycin. Moreover,...
This study sought to investigate incidence and risk factors for acute kidney injury (AKI) in hospitalized COVID-19.In this retrospective study, we enrolled 823 COVID-19 patients with at least two evaluations of renal function during hospitalization from four hospitals Wuhan, China between February 2020 April 2020. Clinical laboratory parameters the time admission follow-up data were recorded. Systemic tubular dysfunction was evaluated via 24-h urine collections a subgroup 55 patients.In...
Rosiglitazone (RGL), a synthetic agonist for peroxisome proliferator activated receptor γ (PPARγ), exhibits potent anti-inflammatory activity by attenuating local infiltration of neutrophils and monocytes in the renal interstitium. To evaluate mechanisms that account inhibiting inflammatory cells infiltration, we investigated effect RGL on chemokines secretion nuclear factor-kappa B (NF-κB) activation human proximal tubular (PTCs). We demonstrated significantly inhibited lipopolysaccharide...
We aimed to investigate the relationship between increased free fatty acid (FFA) level and early postoperative hypoxemia after coronary artery bypass grafting (CABG) with cardiopulmonary (CPB). Ninety-eight consecutive patients undergoing CABG were enrolled. Early was defined as lowest of ratio arterial oxygen tension (PaO2) inspired fraction (FiO2) ≤ 200 mm Hg within 24 h without pleural effusion pneumothorax. The 26 perioperative factors, serum levels FFA inflammatory cytokines...
Objective To search for biomarkers to differentiate primary focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD). Methods We isolated glomeruli from kidney biopsies of 6 patients with adult-onset steroid sensitiveFSGS 5 MCD, compared the profiles glomerular transcriptomes between two groups using microarray analysis. Results Analysis differential expressed genes (DEGs) revealed that up-regulated DEGs in FSGS MCD were primarily involved spermatogenesis, gamete...
Background: Clear cell renal carcinoma (ccRCC) is the most common type of carcinoma, accounting for approximately 70% all RCC cases. Cuproptosis, a novel mechanism death, may be potential target intervention in tumor development. Methods: Cuproptosis-related prognostic lncRNAs were identified by co-expression analysis and univariable Cox regression. Five lncRNA profiles obtained LASSO regression analysis, model with high accuracy was constructed to assess prognosis ccRCC patients based on...
The present study was performed in China to compare the efficacy and safety of an advanced wound dressing made crystalline cellulose (Veloderm) a conventional treatment three Vaseline gauzes management skin donor sites burns or reconstructive plastic surgery. In this prospective, multicenter, open-labeled, randomized clinical trial Chinese burn centers China, 96 patients who required autologous split graft were into either test group control (Vaseline gauze) group. Average healing times...
Patients with extensive burns usually develop pro-coagulation soon after the injury if there is no sepsis occurred. We describe case of an burn adult suffering from hypocoagulation not related to sepsis, but secondary antibiotic treatment.Here, we report a male patient flame 45% total body surface area (40% full thickness) combined inhalation injury. Hypocoagulopathy soaring prolonged activated partial thromboplastin time value occurred on third week post-burn while systemic infection had...
Diabetic nephropathy (DN) is characterized by metabolic disorder and inflammation. However, the regulatory effects that long noncoding RNAs (lncRNAs) have on pathogenesis of DN efficacy rosiglitazone treatment yet to be clearly defined. Herein, we performed unbiased RNA sequencing characterize transcriptomic profiles in db/db diabetic mouse model with or without served improve phenotypes DN. Moreover, RNA-seq profiling revealed development caused an upregulation expression 1176 mRNAs a...
In the paper, we propose a scheme to constrain axion-to-nucleon interaction and non-Newtonian gravity. Here, consider levitated optomechanical system consisting of silica nanosphere an optical cavity. The total force gradient exerted on this modifies its resonance frequency. Based this, have developed quantum method detect two exotic forces. Also, established prospective constraints axion-neucleon coupling constants Yukawa constant. addition, these significantly improve existing bounds.
Introduction Acute kidney injury (AKI) in coronavirus disease 2019 (COVID-19) patients is associated with poor prognosis. Early prediction and intervention of AKI are vital for improving clinical outcome COVID-19 patients. As lack tools early detection patients, this study aimed to validate the USCD-Mayo risk score predicting hospital-acquired an extended multi-center cohort.
The chameleon scalar field is a matter-coupled dark energy candidate with the screening mechanisms. In present paper,we propose quantum cavity optomechanical scheme to detect possible signature of chameleons via optical pump-probe spectroscopy. Compare previous experiment sensitivity can be improved by using electrostatic shield and read weak frequency splitting. We expect that this work will useful addition current literature on proposals effects energy.
Abstract Background Focal and segmental glomerulosclerosis (FSGS) is a histological pathology that characterizes wide spectrum of diseases. Many genes associated with FSGS have been studied previously, but there are still some families reported in the literature without identification known gene mutations. The aim this study was to investigate new genetic cause adult-onset FSGS. Methods This included 40 families, 77 sporadic cases, 157 non-FSGS chronic kidney disease (CKD) 195 healthy...
To assess the effect of enteral nutrition (EN) supplemented with glutamine on recovery after ileal pouch-anal anastomosis (IPAA) in rats, to provide an experimental basis for nutritional support patients ulcerative colitis (UC) IPAA.Male Sprague-Dawley (SD) rats were randomly divided into three groups (n = 8) IPAA operation using a microsurgical technique. From third postoperative day, control group, EN and immune (IN) group fed standard rat chow, short peptide EN, combined ad libitum,...
Background: Recently, a resurgence of pertussis has been observed worldwide despite broad vaccination coverage. The purpose this study was to identify the clinical characteristics and aetiological agent pertussis-like syndrome (PLS) in Eastern China.Methods: 1168 patients who were diagnosed with suspected Bordetella Shanghai Children’s Hospital from 2013 2017 included study. Clinical features aetiologies analysed. Aetiological analyses sub-cohorts age, seasons years also...
The aim of this study was to develop and validate a risk score (RS) for end-stage kidney disease (ESKD) in patients with focal segmental glomerulosclerosis (FSGS).Patient biopsy-proven FSGS enrolled. All the were allocated 1:1 two groups according their baseline gender, age, creatinine level by using stratified randomization method. ESKD primary endpoint.We recruited 359 patients, 177 subjects assigned group 1 182 2. clinicopathological variables similar between groups. There 23 (13%)...