A5100442873- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Vasculitis and related conditions
- Food composition and properties
- Phytochemicals and Antioxidant Activities
- Renal Diseases and Glomerulopathies
- Pleural and Pulmonary Diseases
- Gastric Cancer Management and Outcomes
- Aortic Disease and Treatment Approaches
- Chronic Kidney Disease and Diabetes
- Lung Cancer Research Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Advanced Neural Network Applications
- Tracheal and airway disorders
- Dialysis and Renal Disease Management
- Colorectal Cancer Treatments and Studies
- Tea Polyphenols and Effects
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- AI in cancer detection
- Polysaccharides Composition and Applications
- Metastasis and carcinoma case studies
- Inflammatory Biomarkers in Disease Prognosis
- Nanocomposite Films for Food Packaging
Ruijin Hospital
2011-2025
Shanghai Jiao Tong University
2007-2025
University of Chicago
2022-2025
Liaoning Provincial People's Hospital
2025
Sichuan University
2015-2024
Sun Yat-sen University
2015-2024
Jiangsu University
2022-2024
Dana-Farber/Boston Children's Cancer and Blood Disorders Center
2021-2024
The First Affiliated Hospital, Sun Yat-sen University
2017-2024
Affiliated Hospital of Jiangsu University
2022-2024
IntroductionEpidermal growth factor receptor (EGFR) mutation status was reported to be associated with programmed death-ligand 1 (PD-L1) expression. However, the molecular mechanism of PD-L1 regulation by EGFR activation and potential clinical significance blocking PD-1/PD-L1 in EGFR-mutant non–small-cell lung cancer (NSCLC) treated tyrosine kinase inhibitors (TKIs) were largely unknown.MethodsWestern blot, real-time polymerase chain reaction, immunofluorescence, flow cytometry employed...
The COVID-19 pandemic is a global threat presenting health, economic, and social challenges that continue to escalate. Metapopulation epidemic modeling studies in the susceptible-exposed-infectious-removed (SEIR) style have played important roles informing public health policy making mitigate spread of COVID-19. These models typically rely on key assumption homogeneity population. This certainly cannot be expected hold true real situations; various geographic, socioeconomic, cultural...
Breast cancer is treated with a multidisciplinary approach involving surgical oncology, radiation and medical oncology. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Cancer include recommendations clinical management of patients carcinoma situ, invasive breast cancer, Paget’s disease, Phyllodes tumor, inflammatory during pregnancy. content featured this issue focuses on the overall systemic therapy (preoperative adjuvant) options nonmetastatic cancer. For full...
A two-dimensional multiscale model is introduced for studying formation of a thrombus (clot) in blood vessel. It involves components modelling viscous, incompressible plasma; non-activated and activated platelets; cells; activating chemicals; fibrinogen; vessel walls their interactions. The macroscale dynamics the flow described by continuum Navier-Stokes equations. microscale interactions between platelets, platelets fibrinogen wall are through an extended stochastic discrete cellular Potts...
Driver mutations were reported to upregulate programmed death-ligand 1 (PD-L1) expression. However, how PD-L1 expression and immune function was affected by ALK-TKIs anti-PD-1/PD-L1 treatment in ALK positive non-small-cell lung cancer (NSCLC) remains poorly understood. In the present study, western-blot, real-time PCR, flow cytometry immunofluorescence employed explore regulated fusion protein. relevant inhibitors used identify downstream signaling pathways involved regulation. Cell...
Effects of tea polyphenols (TP) on the physical properties, barrier properties and functionality potato starch-based film were determined, while interaction mechanism between TP starch in application this fruit packaging further evaluated. exhibited different effects film, including thickness (0.083 to 0.087 mm), moisture content (9.27% 9.68%), color (Δ
An extended multiscale model is introduced for studying the formation of platelet thrombi in blood vessels. The describes interplay between viscous, incompressible plasma, activated and non-activated platelets, as well other cells, activating chemicals, fibrinogen vessel walls. macroscale dynamics flow represented by continuous submodel form Navier–Stokes equations. microscale cell-cell interactions are described stochastic Cellular Potts Model (CPM). Simulations indicate that increase rates...
The interaction and action mechanism of starch with different phenolic compounds were investigated. By using scanning electron microscope, nuclear magnetic resonance, Fourier transform infra-red spectroscopy thermogravimetric analysis, exhibited the significant effects on morphology, intensity hydrogen bond, crystalline structure thermal stability starch, respectively. Furthermore, according to analysis molecular dynamics simulation by short-chain glucose (SGS) as model, could change spatial...
Lung cancer postoperative complication prediction (PCP) is significant for decreasing the perioperative mortality rate after lung surgery. In this paper we concentrate on two PCP tasks: (1) binary classification predicting whether a patient will have complications; and (2) three-class multi-label which experience. Furthermore, an important clinical requirement of extraction crucial variables from electronic medical records. We propose novel multi-layer perceptron (MLP) model called MLP...
The effect of tea polyphenols (TP) on the rice starch (RS) was investigated and interaction mechanism between TP RS further analyzed. exhibited a remarkable capacity to affect processing properties (including texture property color) in cold cake. Meanwhile, significant solubility, swelling power, gelatinization property, rheological gel microstructure RS. Furthermore, according molecular dynamics simulation using epigallocatechin gallate (EGCG) two parallel short-chain glucose (SGS) as...
With the gradual popularization of autonomous driving technology, how to obtain traffic sign information efficiently and accurately is very important for subsequent decision-making planning tasks. Traffic detection recognition (TSDR) algorithms include color-based, shape-based, machine learning based. However, mentioned above are insufficient tasks in complex environments. In this paper, we propose a paradigm based on deep algorithms. First, solve problem spatial high-level features small...
This study set out to develop a computed tomography (CT)-based wavelet transforming radiomics approach for grading pulmonary lesions caused by COVID-19 and validate it using real-world data.This retrospective analyzed 111 patients with 187 from 16 hospitals; all had confirmed underwent non-contrast chest CT. Data were divided into training cohort (72 127 nine hospitals) an independent test (39 60 seven according the hospital in which CT was performed. In all, 73 texture features extracted...
Importance Triple-negative breast cancer (TNBC) disproportionately affects Black women. Immunotherapy improves outcomes in early-stage TNBC (esTNBC) and metastatic (mTNBC). However, racial ethnic disparities immunotherapy receipt its potential association with oncologic are unknown. Objective To examine trends differences pathologic complete response (pCR) overall survival (OS) TNBC. Design, Setting, Participants This retrospective cohort study analyzed the 2019-2021 National Cancer...
Objectives To observe the effect of roxadustat on lowering blood lipids in peritoneal dialysis (PD) patients beyond treating anemia.