A5022537642- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Advanced Photocatalysis Techniques
- Chromium effects and bioremediation
- Arsenic contamination and mitigation
- Ginkgo biloba and Cashew Applications
- Copper-based nanomaterials and applications
- Platelet Disorders and Treatments
- Infrared Thermography in Medicine
- Celiac Disease Research and Management
- Electrocatalysts for Energy Conversion
- Heavy metals in environment
- Autoimmune Bullous Skin Diseases
- Pediatric Urology and Nephrology Studies
- Quantum Dots Synthesis And Properties
- Renal and Vascular Pathologies
- Autophagy in Disease and Therapy
- Genomics and Phylogenetic Studies
- Covalent Organic Framework Applications
- Microbial Community Ecology and Physiology
- Blood groups and transfusion
- Phonocardiography and Auscultation Techniques
- Biological Research and Disease Studies
- Urban and spatial planning
- Single-cell and spatial transcriptomics
Anhui Normal University
2022-2024
Traditional Chinese Medicine Hospital of Kunshan
2020-2024
Shanghai University of Traditional Chinese Medicine
2020-2024
Leshan Normal University
2024
Nanjing Forestry University
2024
Hefei Institutes of Physical Science
2023
Jiangnan University
2022-2023
Wuhan University
2023
Renmin Hospital of Wuhan University
2023
China Rehabilitation Research Center
2023
Antimony (Sb) and its compounds are listed by the United States Environmental Protection Agency (USEPA, 1979) European Union (CEC, 1976) as a priority pollutant. Microbial redox transformations presumed to be an important part of antimony cycling in nature; however, regulation these processes enzymology involved unknown. In this study, comparative proteomics reverse transcriptase-PCR analysis Sb(III)-oxidizing bacterium Agrobacterium tumefaciens GW4 revealed oxidoreductase (anoA) is widely...
A working group on the Oxford classification of IgA nephropathy (IgAN) recently reported that crescents detected in kidney tissue predicted a worse renal outcome. However, this finding must be validated independent cohorts before it can widely applied to clinical practice. Biopsy-proven IgAN patients were continuously recruited from two large centers China 1989 2014. All followed for more than 1 year unless end stage disease (ESRD) occurred within 12 months. Crescents defined as focal...
Antimonite [Sb(III)]-oxidizing bacteria can transform the toxic Sb(III) into less antimonate [Sb(V)]. Recently, cytoplasmic Sb(III)-oxidase AnoA and periplasmic arsenite [As(III)] oxidase AioAB were shown to responsible for bacterial oxidation, however, disruption of each gene only partially decreased oxidation efficiency. This study showed that in Agrobacterium tumefaciens GW4, induced cellular H2O2 content degradation katA. Gene knock-out/complementation katA, anoA, aioA anoA/aioA growth...
Background and objectives At least 20 susceptibility loci of IgA nephropathy have been identified by genome-wide association studies to date. Whether these were associated with disease progression is unclear. Design, setting, participants, & measurements We enrolled 613 adult patients for a follow-up ≥12 months. All selected their tag single nucleotide polymorphisms (SNPs) genotyped. After strict quality control, 16 SNPs 517 eligible subsequent analysis. Progression was defined as ESKD...
Atomically precise Pd clusters/CdS nanorod photocatalysts were constructed for photocatalytic cooperative highly selective oxidation of benzyl alcohol to benzaldehyde and H 2 production.
Idiopathic membranous nephropathy (IMN) is a leading pathological type of the adult primary nephrotic syndrome. Some patients develop end-stage renal disease due to poor response treatment with steroid and immunosuppressive agents. In order explore molecular mechanism IMN, we collected tissue samples from IMN healthy controls performed analysis by single-cell RNA sequencing (scRNA-seq). A total 11 kidney cell clusters were identified, including multiple myeloid clusters, NK/T B clusters....
Agrobacterium tumefaciens GW4 is a heterotrophic arsenite [As(III)]/antimonite [Sb(III)]-oxidizing strain. The As(III) oxidase AioAB responsible for oxidation in the periplasm and it also involved Sb(III) 5A. In addition, AnoA cellular H2O2 are strain GW4. However, deletion of aioA increased efficiency present study, we found that cell mobility to Sb(III), ATP NADH contents heat release were by more significantly mutant. Proteomics transcriptional analyses showed proteins/genes resistance,...
The aim of this study was to investigate the association between lectin pathway-related genetic variations and progression in IgA nephropathy. Biopsy-proven IgAN patients with eGFR ≥15 ml/min/1.73 m2 at baseline a minimum follow-up 12-months were enrolled. A total 1,007 121 healthy controls enrolled from two Chinese renal centers. discovery cohort consisted 606 patients, validation 401 patients. First, promoters, all exons their boundary regions MBL2 FCN2 sequenced 50 then 37 identified. Of...
A Gram-staining-negative, strictly aerobic, non-spore-forming, rod-shaped bacterium, designated WG4T, was isolated from soil of the Tianmen Mountain located in Hunan province, PR China. 16S rRNA gene sequence analysis showed that strain belongs to genus Chryseobacterium family Flavobacteriaceae, with 97.4 % and 97.1 identities anthropi NF 1366T haifense H38T, respectively. In comparison other strains representing Chryseobacterium, were less than 97.0 %. The DNA-DNA relatedness values 63.3...
Exfoliation and interfacial modification of two-dimensional (2D) polymeric carbon nitride (CN) are considerably vital for applications in photo/electrocatalysis fields. Here, a grinding-ultrasonic route was designed to construct nickel bis(chelate) complex (Ni(abt)2, abt = 2-aminobenzenethiolate)-modified CN ultrathin nanosheets. Under the assistance shear force derived from grinding process, Ni(abt)2 implanted into interlamination bulk CN, resulting formation (UCN) Simultaneously, molecules...
We aimed to validate three IgAN risk models proposed by an international collaborative study and another CKD model generated extended cohort with our multicenter Chinese cohort. Biopsy-proven patients eGFR ≥15 ml/min/1.73 m2 at baseline a minimum follow-up of 6 months were enrolled. The primary outcomes composite outcome (50% decline in or ESRD) ESRD. performance those was assessed using discrimination, calibration, reclassification. A total 2,300 eligible cases Of them, 288 (12.5%) reached...
// Meng Yang 1 , Jingyuan Xie Yan Ouyang Xiaoyan Zhang Manman Shi Xiao Li Zhaohui Wang Pingyan Shen Hong Ren Wen Weiming and Nan Chen Department of Nephrology, Institute Ruijin Hospital, Shanghai Jiao Tong University School Medicine, Shanghai, China Correspondence to: Chen, email: Xie, Keywords : IgA nephropathy, ABO blood group, renal progression, end-stage disease, clinical follow-up, Immunology Microbiology Section, Immune response, Immunity Received July 18, 2017 Accepted August 06,...
Unambiguous evidence indicates that microbes are closely linked to various human diseases, including cancer. Most prior work investigating the microbiome of breast tissue describes an association between compositional differences microbial species in benign and malignant tissues, but few studies have examined relative abundance communities within at level. In this work, a total 44 samples tissues with adjacent normal pairs were collected, Oxford Nanopore long-read sequencing was employed...
The pathogenesis of membranous nephropathy (MN) involves podocyte injury that is attributed to inflammatory responses induced by local immune deposits. Astragaloside IV (AS-IV) known for its robust anti-inflammatory properties. Here, we investigated the effects AS-IV on passive Heymann nephritis (PHN) rats and TNF-α-induced podocytes determine underlying molecular mechanisms MN. Serum biochemical parameters, 24-h urine protein excretion renal histopathology were evaluated in PHN control...
IntroductionFamilial IgA nephropathy (IgAN) has been widely reported. However, its clinicohistologic characteristics and long-term prognosis are not clear.MethodsA total of 348 familial IgAN cases from 167 independent families were recruited their as well lifetime risk end-stage renal disease (ESRD) compared to 1116 sporadic patients the same geographic region.ResultsOf all patients, 60 (17%) came 32 single-generation (SG; affected individuals siblings) families, whereas 286 (82%) 134...
Abstract Paenibacillus ferrarius CY1 T (= KCTC 33419 = CCTCC AB2013369 ) is a Gram-positive, aerobic, endospore-forming, motile and rod-shaped bacterium isolated from iron mineral soil. This reduces sulfate (SO 4 2− to S , which reacts with Cd(II) generate precipitated CdS. It also the toxic chromate [Cr(VI)] selenite [Se(VI)] less bioavailable chromite [Cr(III)] selenium (Se 0 ), respectively. Thus, strain has potential bioremediate Cd, Cr Se contamination, main reason for interest in...