A5034267064- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Spondyloarthritis Studies and Treatments
- Spine and Intervertebral Disc Pathology
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Organ Transplantation Techniques and Outcomes
- Nanoplatforms for cancer theranostics
- Cancer, Lipids, and Metabolism
- Inflammatory mediators and NSAID effects
- MicroRNA in disease regulation
- Endometrial and Cervical Cancer Treatments
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Metabolomics and Mass Spectrometry Studies
- Dermatology and Skin Diseases
- Genetic factors in colorectal cancer
- Liver Disease and Transplantation
- Renal Diseases and Glomerulopathies
- Chemistry and Stereochemistry Studies
- Renal and Vascular Pathologies
- Machine Learning in Materials Science
- Single-cell and spatial transcriptomics
Shanghai University of Traditional Chinese Medicine
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Xiyuan Hospital
2024
Beijing University of Chinese Medicine
2010-2024
Changhai Hospital
2018-2023
Second Military Medical University
2018-2023
Xijing Hospital
2022
Air Force Medical University
2022
National Clinical Research
2014-2022
Beijing Hospital
2022
Because of the early onset local invasion and distant metastasis, pancreatic ductal adenocarcinoma (PDAC) is most lethal human malignant tumor, with a 5-year survival rate less than 5%. In this study, we investigated role fascin, prometastasis actin-bundling protein, in PDAC progression, invasion, molecular mechanisms underlying fascin overexpression PDAC. Our data showed that expression levels were higher cancer tissues normal tissues, correlated differentiation prognosis. Fascin promoted...
Objectives: Intervertebral disc degeneration is a progressive and chronic disease, usually manifesting as low back pain. This study aimed to screen effective biomarkers for medical practice well figuring out immune infiltration situations between circulation intervertebral discs. Methods: Gene expression profiles of GSE124272 was included differentially analysis, WGCNA analysis from GEO database, other GSE series were used validation datasets. A methods conducted verify the robustness hub...
Idiopathic membranous nephropathy (IMN) is a leading pathological type of the adult primary nephrotic syndrome. Some patients develop end-stage renal disease due to poor response treatment with steroid and immunosuppressive agents. In order explore molecular mechanism IMN, we collected tissue samples from IMN healthy controls performed analysis by single-cell RNA sequencing (scRNA-seq). A total 11 kidney cell clusters were identified, including multiple myeloid clusters, NK/T B clusters....
Owing to the limitations of single-mode cancer treatments, combination therapies have attracted much attention. However, constructing a platform for in simple and effective way improving overall treatment effect remains challenge. Our aim was combine sonodynamic therapy, radiotherapy chemotherapy together improve therapeutic outcomes within one nanoplatform. In this work, we sought exploit properties nanoscale heterojunctions end. A multifunctional Bi2O3-TiO2@polydopamine-doxorubicin (BTPD)...
Single nucleotide polymorphisms (SNPs) in the DNA repair genes are suspected to be related survival of lung cancer patients due their possible influence on capacity (DRC). However, study results inconsistent.A follow-up 610 non-small cell (NSCLC) was conducted investigate genetic associated with relation NSCLC survival; 6 SNPs were genotyped, including XRCC1 (rs25487 G>A), hOGG1 (rs1052133 C>G), MUTYH (rs3219489 G>C), XPA (rs1800975 ERCC2 (rs1799793 G>A) and XRCC3 (rs861539 C>T). Kaplan-...
The morbidity and mortality rates of patients with non-alcoholic fatty liver disease (NAFLD) have been steadily increasing in recent years. Previous studies confirmed the important role ferroptosis NAFLD development; however, precise mechanism through which influences occurrence remains unclear. present study aimed to identify validate ferroptosis-related genes involved pathogenesis investigate underlying molecular mechanisms NAFLD.We downloaded microarray datasets GSE72756 GSE24807...
As one of the most troublesome complications in patients with chronic renal disease, etiology uremic pruritus remains unknown, and current therapeutic approaches are limited unsatisfactory. To identify potential biomarkers for improving diagnosis treatment obtain a better understanding pathogenesis pruritus, we compared serum metabolome profiles severe (HUP) mild (LUP) using ultraperformance liquid chromatography-quadruple time-of-flight mass spectrometry (UPLC-QTOF MS). Partial least...
There are two types of esophageal varices (EVs): high-risk EVs (HEVs) and low-risk EVs, HEVs pose a greater threat to patient life than EVs. The diagnosis is mainly conducted by gastroscopy, which can cause discomfort patients, or non-invasive prediction models. A number models for predicting have been reported; however, those that based on the formula calculation liver spleen volume in not reported.To establish model patients with viral cirrhosis.Data from 86 EV cirrhosis were collected....
Abstract Background The morbidity and mortality rates for non-alcoholic fatty liver disease (NAFLD) have been steadily increasing in recent years. Studies shown that ferroptosis plays a significant role the development of NAFLD, but exact mechanism has not yet clarified. This study aimed to identify validate potential ferroptosis-related genes involved NAFLD explore underlying molecular mechanisms disease. Methods We downloaded microarray datasets GSE72756 GSE24807 at Gene Expression...
Abstract Background Lung cancer is the leading cause of cancer-related death worldwide, among which lung adenocarcinoma (LUAD) most common type. Identified as a hallmark cancer, dysregulated cell cycle progression plays an important role in promotion and LUAD. This article aims to elucidate heterogeneity between CDKN2A-CDK/cyclin-RB1 pathway altered /non-altered patients with LUAD, thus helping us have better understanding effect aberrant cycle. Material Methods The data this study were...