A5100610588- Nonlinear Optical Materials Research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Nonlinear Optical Materials Studies
- DNA and Nucleic Acid Chemistry
- Crystallography and molecular interactions
- Chemical synthesis and pharmacological studies
- Synthesis and Biological Evaluation
- Genomics, phytochemicals, and oxidative stress
- Complement system in diseases
- Renal Diseases and Glomerulopathies
- Metal complexes synthesis and properties
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Synthesis and Characterization of Heterocyclic Compounds
- Porphyrin and Phthalocyanine Chemistry
- Platelet Disorders and Treatments
- Luminescence and Fluorescent Materials
- Synthesis and properties of polymers
- Dyeing and Modifying Textile Fibers
- Sirtuins and Resveratrol in Medicine
- Photochromic and Fluorescence Chemistry
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Phytochemistry and Bioactive Compounds
- Asymmetric Synthesis and Catalysis
Soochow University
2008-2024
First Affiliated Hospital of Soochow University
2008-2024
Nanjing University
2005-2015
Nanjing Forestry University
2013-2015
Shanghai Jiao Tong University
2008-2009
Konkuk University
2009
Southeast University
2006-2008
State Key Laboratory of Pharmaceutical Biotechnology
2007
Diabetic nephropathy (DN) is a serious complication that commonly confronted by diabetic patients. A common theory for the pathogenesis of this renal dysfunction in diabetes cell injury, inflammation as well oxidative stress. In content, detailed molecular mechanism underlying high glucose induced tubular epithelial injury was elaborated.An vivo rat model injecting streptozotocin (STZ) and an vitro incubated (HK-2) were used. Expression levels Keap1, nuclear Nrf2 p65 determined western...
A series of novel second-order nonlinear optical chromophores with two non-conjugated D−π−A units have been synthesized that exhibit much higher first hyperpolarizability (β) values than the corresponding mono-D−π−A unit compounds a slight red shift.
The current study was designed to investigate the protective effect and possible mechanisms of umbelliferone (Umb) on liver injury in diabetic C57BL/KsJ-db/db (dbdb) mice. Mice were divided into five groups: wild-type mice group (WY), dbdb group, + Metformin (100 mg/kg) Umb (20, 40 group. Blood glucose regulation assessed by an oral tolerance test (OGTT). At 28 days after drug administration, blood samples obtained for analysis lipids enzymes related hepatic function, including alanine...
A series of H-shaped second-order nonlinear optical (NLO) chromophores with two parallel and nonconjugated D−π−A units have been synthesized, in which a 9,10-dihydroanthracene is employed as molecular backbone. The measurement results hyper-Rayleigh scattering (HRS) UV−vis spectra show that the first hyperpolarizability (β) values are remarkably increased compared corresponding mono-D−π−A unit reference compounds (the enhancements per azo from 1.2 to 3.0 observed), without causing large...
A novel and improved methodology is still required for the diagnosis of diabetic kidney disease (DKD). The aim present study was to identify biomarkers using extracellular vesicle (EV)-derived mRNA based on tissue microarray data.Candidate genes were identified by intersecting differentially expressed (DEGs) eGFR-correlated GEO datasets GSE30528 GSE96804, followed clinical parameter correlation diagnostic efficacy assessment.Fifteen genes, including 8 positively correlated B3GALT2, CDH10,...
A novel phosphodiester receptor 1-(2-guanidinoethyl)-4-(2-hydroxyethyl)-1,4,7-triazacyclononane hydrochloride 1 was synthesized. DNA cleavage efficiency of exhibits remarkable increases compared with its ZnII complex and corresponding nonguanidinium compound N-(2-hydroxyethyl)-1,4,7-triazacyclononane parent 1,4,7-triazacyclononane. Kinetic data promoted by fit to a Michaelis−Menten-type equation kmax 0.160 h-1 giving 107-fold rate acceleration over uncatalyzed DNA. The is driven the spatial...
Our research investigates the serum levels of three angiogenic factors in AF family, namely, placenta growth factor (PlGF), basic fibroblast (bFGF), and vascular endothelial (VEGF), 54 patients with SLE (SLE group) 28 healthy controls (normal control) through ELISA measurement. And their interrelationships were also systematically analyzed. The then divided into active group inactive according to SLEDAI score. results show that PlGF, bFGF, VEGF all higher than those normal controls. Serum...
Four chromophores containing bromo substituents, a ployimide with bromo-containing chromophores, four reference functional polyimides, and fourteen were synthesized for studying effect of substituents on nonlinear optical (NLO) properties materials chromophores. The results hyper-Rayleigh scattering UV−vis spectra show that static first molecular hyperpolarizability (β0) values are 1.24−5.75 times as β0 the corresponding chloro-containing (Hammett constants σ chloro groups same) without...
von Willebrand factor (vWF) mediates the initial capture of platelets to vascular subendothelium and is essential for platelet aggregation under high fluid shear stress as in arterial stenosis. On release from endothelial cells, vWF rapidly cleaved by ADAMTS13/vWF-cleaving protease (vWF-CP). We investigated clinical significance changes plasma vWF-CP activities chronic renal disease.Plasma were measured using enzyme-linked immunosorbent assay (ELISA) residual collagen binding respectively...
1,4,7-Triazacyclononane (TACN), with DNA cleaving ability, was appended to anthraquinone via different spacers construct the new compounds 1,8-[2,2′-(1,4,7-triazacyclonon)diethoxy] anthracene-9,10-dione hydrochloride (1) and 1,8-[2,2′-(1,4,7-triazacyclonon)dihexyloxy] (2) as agents for metal-free cleavage. Fluorescence CD spectroscopic studies suggest an intercalating binding mode, apparent constants of 1 2 are 3.93 × 107 6.07 M−1, respectively. Compound 2, bearing longer spacer, exhibits...
The pathogenesis of membranous nephropathy (MN) involves podocyte injury that is attributed to inflammatory responses induced by local immune deposits. Astragaloside IV (AS-IV) known for its robust anti-inflammatory properties. Here, we investigated the effects AS-IV on passive Heymann nephritis (PHN) rats and TNF-α-induced podocytes determine underlying molecular mechanisms MN. Serum biochemical parameters, 24-h urine protein excretion renal histopathology were evaluated in PHN control...
The mono, bis, tris and tetrakis (p-nitrophenyl)azo calix[4]arenes (1, 2, 3 4) with NLO properties are synthesized by the diazo-coupling of calix[4]arene p-nitrophenyl diazonium. HRS measurements at 1064 nm indicate that have higher second-order hyperpolarizability β values than corresponding reference compound 4-(4-nitrophenylazo)-2,6-dimethylphenol, without red shift charge transfer band. bis (2, 3) hydrophobic alkyl chains can form stable Langmuri monolayers air/water interface because...
Chromophores containing two parallel nonconjugated D-pi-A units are effective chromophores with high hyperpolarizability and good optical transparency. It provides a method for the design synthesis of chromophores. The semiempirical ZINDO was employed to study relationship between enhancement static first hyperpolarizabilities (beta0) per unit number in chromophore. results show that would exhibit higher beta0 values than times value corresponding reference chromophore unit. three exhibits...
Abstract New metal‐free DNA cleaving reagent 1 , 1,4,7‐triazacrown (TACN) both with aminoethyl, hydroxyethyl side arms and a planar anthraquinone linked by an alkyl (1,6‐hexamethylene) spacer has been synthesized characterized NMR MS spectrometry. For comparison, the corresponding triazacrown derivative 2 without also synthesized. DNA‐binding properties via fluorescence CD spectroscopy indicate that binding affinity of is much stronger than . Agarose gel electrophoresis was used to assess...
Abstract Background We aim to investigate the protective effects and potential mechanisms in specneuzhenide (SPE) on renal injury rats with diabetic nephropathy (DN). Results SPE could inhibit decrease of body weight compared model group (P<0.05), trigger improvement index (P<0.05). High dose low a significant serum IL1β, IL-6 TNF-α attenuate glomerular lesions DN rats. induced up-regulation podocin CD2AP Conclusion showed through attenuating pathological urine protein. This process...
Abstract The p ‐nitrophenylazo calix[4]arene derivatives 1a‐1d with nonlinear optical (NLO) properties were prepared by the diazo‐coupling reaction of ‐nitrophenyl diazonium. diazotization ‐nitroaniline was carried out isoamyl nitrite as a source nitrous add in EtONa/EtOH under refluxing condition. X‐Ray crystallographic analysis and 1 H NMR spectra reveal that they exist cone conformation crystal state or solution. HRS measurements at 1064 nm THF indicate ‐nitro‐phenylazo calix[4]arenes...