A5102870348- Hepatitis B Virus Studies
- Renal Diseases and Glomerulopathies
- Ion Transport and Channel Regulation
- Vasculitis and related conditions
- Fungal Infections and Studies
- Immunotherapy and Immune Responses
- Mycobacterium research and diagnosis
- Hepatitis C virus research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dialysis and Renal Disease Management
- Infectious Diseases and Mycology
- Tuberculosis Research and Epidemiology
- Liver Disease Diagnosis and Treatment
- Genetic Syndromes and Imprinting
- Bacteriophages and microbial interactions
- Urticaria and Related Conditions
- Connective tissue disorders research
- Chronic Kidney Disease and Diabetes
- Ion channel regulation and function
- Toxoplasma gondii Research Studies
- Muscle and Compartmental Disorders
- Extracellular vesicles in disease
- Systemic Lupus Erythematosus Research
- Vitamin D Research Studies
- Antimicrobial Resistance in Staphylococcus
Ruijin Hospital
2012-2025
Shanghai Jiao Tong University
2010-2025
Lianyungang Oriental Hospital
2018-2025
Xuzhou Medical College
2018-2025
Zhejiang A & F University
2025
Shanghai Children's Medical Center
2023-2025
The First People’s Hospital of Lianyungang
2010-2024
Kangda College of Nanjing Medical University
2019-2024
Nanjing Medical University
2019-2024
First Hospital of Qinhuangdao
2010-2022
Background— Individuals with vascular or valvular calcification are at increased risk for coronary events, but the relationship between calcium consumption and cardiovascular events is uncertain. We evaluated of cerebrovascular in Women’s Health Initiative randomized trial plus vitamin D supplementation. Methods Results— 36 282 postmenopausal women 50 to 79 years age 40 clinical sites carbonate 500 mg 200 IU twice daily placebo. Cardiovascular disease was a prespecified secondary efficacy...
The inherited deficiency of adenosine deaminase (adenosine aminohydrolase; EC 3.5.4.4) activity in humans is associated with an immunodeficiency. Some the immunodeficient and enzyme-deficient patients respond immunologically to periodic infusions irradiated erythrocytes containing deaminase. It has been previously reported that lymphocytes from ane children contained increased concentrations ATP, one child studied after erythrocyte infusion therapy, intracellular level ATP diminished. Using...
Trained immunity refers to the long-term memory of innate immune cells. However, little is known about how environmental nutrient availability influences trained immunity. This study finds that physiologic carbon sources impact glucose contribution tricarboxylic acid (TCA) cycle and enhance cytokine production monocytes. Our experiments demonstrate monocytes preferentially employe lactate over as a TCA substrate, metabolism required for cell responses bacterial fungal infection. Except...
Background and Purpose— Many studies have shown a U-shape association between sleep duration mortality, but epidemiological evidence linking cardiovascular diseases with habitual patterns is limited mixed. Methods— We conducted prospective study on 93 175 older women (aged 50 to 79 years) in the Women’s Health Initiative Observational cohort examine risk of ischemic stroke relation self-reported duration. Cox models were used investigate putative associations, adjusting for multiple...
MAVS is an adapter protein involved in RIG-I-like receptor (RLR) signaling mitochondria, peroxisomes, and mitochondria-associated ER membranes (MAMs). However, the role of glucose metabolism RLR cross-regulation how these pathways are coordinated among organelles have not been defined. This study reports that action drives a switch from glycolysis to pentose phosphate pathway (PPP) hexosamine biosynthesis (HBP) through MAVS. We show peroxisomal responsible for flux shift into PPP type III...
In order to evaluate the clinical and pathological characteristics of diuretics associated acute kidney injury (AKI) its management.We performed a retrospective study including 131 cases that diagnosed as AKI from 1 January 1999 2010 in Ruijin Hospital affiliated Shanghai Jiao Tong University. Drug applications related clinical, laboratory histological data were collected.The male female ratio was 2:1. The proportion ages <20 years, 20-40 40-60 years ≥ 60 6.9%, 17.6%, 27.5% 48.1%...
<b><i>Background:</i></b> Gitelman syndrome (GS) is an autosomal recessive disease of renal tubulopathy, primarily characterized by hypokalemic metabolic alkalosis with significant hypomagnesemia, low urinary calcium, secondary aldosteronism and normal blood pressure. Both hypokalemia hypomagnesemia were reported to cause impaired glucose tolerance and/or insulin resistance, but it unclear whether resistance are common in GS patients....
Vancomycin is a first-line antibiotic used for the treatment of severe gram-positive bacterial infections. Clinical guidelines recommend that vancomycin trough concentration be 10-15 mg/L regular infections and 15-20 We investigated whether increasing would result in better clinical outcomes with sustainable adverse effects (AEs) Chinese population.A prospective, open, multicenter observational study was performed patients from 13 teaching hospitals. Patients received therapeutic drug...
<b><i>Background:</i></b> Gitelman syndrome (GS) is an autosomal recessive renal tubulopathy caused by inactivating mutations in the <i>SLC12A3</i> gene. Although hundreds of different across gene have been reported worldwide, data from mainland China are limited. We investigated clinical manifestations and genetic features Chinese patients with GS. <b><i>Methods:</i></b> Fifty-four unrelated clinically diagnosed GS were included....
Geographical named entity matching, a crucial step in address encoding, aims to enhance resolution accuracy through the precise identification and linkage of geographical data. However, existing approaches tend ignore spatial information entities, leading misclassification. Drawing on human process searching for addresses, this study proposes multi-objective learning model GNEMM that integrates semantic entities. To further mimic cognitive during search, it incorporates Retrieval-Augmented...
This cohort study evaluated the effectiveness and safety of photodynamic therapy (PDT) alone combined with antibiotics for treatment cutaneous Mycobacterium marinum infections.
Background. To investigate the promoter mutations of ACTN4 and SYNPO genes in patients with idiopathic focal segmental glomerulosclerosis (FSGS), to provide functional analysis these role FSGS occurrence. Methods. The study consisted 82 Chinese (55 had nephrotic syndrome: NS) 90 healthy individuals. Genomic DNA extracted from peripheral leukocytes individuals were used analyse gene by polymerase chain reaction (PCR) direct sequencing. Mutations matched GenBank TRANSFAC software database...
Primary antineutrophil cytoplasmic antibodies (ANCA)-associated systemic vasculitis (AASV) used to have poor prognosis, and renal involvement is its most common manifestation. Few studies been published focusing on AASV patients with prognosis.From 1997 2006, 101 ANCA-associated (70 microscopic polyangiitis, MPA; 14 Wegener's granulomatosis, WG; 3 Churg-Strauss syndrome, CSS; limited vasculitis, RLV) were diagnosed in Shanghai Ruijin Hospital 26 deaths recorded among them. Patients' data...
Objective. Renal involvement is frequently present in primary antineutrophil cytoplasmic antibody-associated small-vessel vasculitis (AAV) as well propylthiouracil (PTU)-induced AAV. We analyzed the characteristics of patients with PTU-induced AAV renal and investigated differences 2 diseases. Methods. Thirty-six AAV, diagnosed from 1997 to 2010, were enrolled for study. Their data compared those 174 at same time. was all patients. Results. There a prominent proportion young women (p <...
Objectives To observe the effect of roxadustat on lowering blood lipids in peritoneal dialysis (PD) patients beyond treating anemia.
Abstract Background IgA Nephropathy (IgAN) is one of the most common causes primary glomerulonephritis that lacks specific treatment option. This study aimed to evaluate efficacy and safety telitacicept in patients with IgAN. Methods We performed a retrospective analysis 82 biopsy-proven IgAN baseline eGFR &gt; 20 ml/min/1.73m2 proteinuria ≥ 1 g/d. 41 were treated angiotensin-converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB). They divided into extended group (treated...
Inactivating mutations of the SLC12A3 gene are most common cause Gitelman's syndrome (GS), a disorder inherited as an autosomal recessive trait. In minority cases, GS-like phenotypes caused by in CLCNKB gene.We searched for and 13 Chinese patients (9 males 4 females, age 35 +/- 14 years) from 8 unrelated families with clinical biochemical features GS. All coding regions, including intron-exon boundaries, were analyzed using PCR followed direct sequence analysis.We identified 10 distributed...
A procedure that uses the PCR to make rapid successive steps through a random-primed cDNA library has been developed provide method for sequencing very long genes are difficult obtain as single clone. In each step, portions of partial clones extend out from region known DNA sequence amplified by two stages with nested, outward-directed primers designed approximately 50 bases in end sequence, together general primer based on vector. This used determine coding beta heavy chain axonemal dynein...
A large cytoplasmic domain accounts for approximately one-third of the entire protein one superfamily ligand-gated membrane ion channels, which includes nicotinic acetylcholine (nACh), γ-aminobutyric acid type (GABAA), serotonin 3 (5-HT3), and glycine receptors. Desensitization is functional feature shared by these Because most molecular studies receptor desensitization have focused on agonist binding channel pore domains, relatively little known about role (LCD) in this process. To address...