A5101540404- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Ischemia and Reperfusion
- Acute Ischemic Stroke Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Pancreatic and Hepatic Oncology Research
- Spine and Intervertebral Disc Pathology
- Neurological diseases and metabolism
- Gallbladder and Bile Duct Disorders
- Migraine and Headache Studies
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Photoreceptor and optogenetics research
- Musculoskeletal pain and rehabilitation
- Tendon Structure and Treatment
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Mechanisms and Therapy
- Spinal Cord Injury Research
- Trigeminal Neuralgia and Treatments
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
Massachusetts General Hospital
2007-2025
Nanning Normal University
2025
Montreal Neurological Institute and Hospital
2024-2025
Harvard University
2007-2025
McGill University
2024-2025
Nanjing Medical University
2021-2024
Jiangsu Province Hospital
2021-2024
Yunnan University
2024
Weatherford College
2024
SKiN Health
2024
IntroductionEpidermal growth factor receptor (EGFR) mutation status was reported to be associated with programmed death-ligand 1 (PD-L1) expression. However, the molecular mechanism of PD-L1 regulation by EGFR activation and potential clinical significance blocking PD-1/PD-L1 in EGFR-mutant non–small-cell lung cancer (NSCLC) treated tyrosine kinase inhibitors (TKIs) were largely unknown.MethodsWestern blot, real-time polymerase chain reaction, immunofluorescence, flow cytometry employed...
Subtalar osteoarthritis (STOA) is often secondary to chronic ankle sprains, which seriously affects the quality of life patients. Due its etiology and pathogenesis was not studied equivocally yet, there currently a lack effective conservative treatments. Although they have been used for tissue repair, platelet-rich plasma-derived exosomes (PRP-Exo) disadvantage low retention short-lived therapeutic effects. This study aimed determine whether incorporation PRP-Exo in thermosensitive hydrogel...
Driver mutations were reported to upregulate programmed death-ligand 1 (PD-L1) expression. However, how PD-L1 expression and immune function was affected by ALK-TKIs anti-PD-1/PD-L1 treatment in ALK positive non-small-cell lung cancer (NSCLC) remains poorly understood. In the present study, western-blot, real-time PCR, flow cytometry immunofluorescence employed explore regulated fusion protein. relevant inhibitors used identify downstream signaling pathways involved regulation. Cell...
Cortical spreading depolarizations (CSDs) are intense and ubiquitous depolarization waves relevant for the pathophysiology of migraine brain injury. CSDs disrupt blood-brain barrier (BBB), but mechanisms unknown.
Disruption of the blood-spinal cord barrier (BSCB) leads to inflammatory cell infiltration and neural death, thus, contributing poor functional recovery after spinal injury (SCI). Previous studies have suggested that Sirtuin 1 (SIRT1), an NAD+-dependent class III histone deacetylase, is abundantly expressed in endothelial cells promotes homeostasis. However, role SIRT1 BSCB function SCI remains poorly defined. Here, we report highly cells, its expression significantly decreases SCI. Using...
Cortical spreading depolarization (CSD) induces pro-inflammatory gene expression in brain tissue. However, previous studies assessing the relationship between CSD and inflammation have used invasive methods that directly trigger inflammation. To eliminate injury confounder, we induced CSDs non-invasively through intact skull using optogenetics Thy1-channelrhodopsin-2 transgenic mice. We corroborated our findings by minimally KCl-induced thinned skull. Six over 1 h dramatically increased...
Abstract Spreading depression (SD) is an intense and prolonged depolarization in the central nervous systems from insect to man. It implicated neurological disorders such as migraine brain injury. Here, using vivo mouse model of focal neocortical seizures, we show that SD may be a fundamental defense against seizures. Seizures induced by topical 4-aminopyridine, penicillin or bicuculline, systemic kainic acid, culminated SDs at variable rate. Greater seizure power area recruitment predicted...
Abstract Background The geographic distribution and host-parasite interaction networks of Sarcocystis spp. in small mammals eastern Asia remain incompletely known. Methods Experimental infections, morphological molecular characterizations were used for discrimination a new species isolated from colubrid snakes collected Thailand, Borneo China. Results We identified species, muricoelognathis sp. nov., that features relatively wide infects both commensal forest-inhabiting intermediate hosts....
Spinal cord ischemia-reperfusion (IR) injury (SCIRI) is a significant secondary that causes damage to spinal neurons, leading the impairment of sensory and motor functions. Excessive reactive oxygen species (ROS) production considered one critical mechanism neuron in SCIRI. Nonetheless, molecular mechanisms underlying resistance neurons ROS remain elusive. Our study revealed deletion Git1 mice led poor recovery function after Furthermore, we discovered has beneficial effect on production....
This study proposes an Additive Wavelet Transform (AWT)-based method to fuse Multispectral UAV (MS UAV, 5 cm resolution) and Sentinel-2 satellite imagery (10–20 m resolution), generating resolution fused images with a focus on near-infrared shortwave infrared bands enhance the accuracy of mango canopy water content monitoring. The MS data were validated calibrated using field-collected hyperspectral construct vegetation indices, which then used five machine learning (ML) models estimate Fuel...
Background Ischemic stroke is among the most prevalent diseases, with high death and morbidity. Numerous preclinical studies have reported efficacious interventions in rodent models. However, reperfusion therapies remain only clinically intervention to date. Rigor reproducibility are now recognized as critical bridge preclinical–clinical disconnect. Inter‐α inhibitor proteins (IαIPs) a family of structurally related glycoproteins 2 major forms (inter‐α pre‐α inhibitor) blood. Purified human...
Among LRRK2-associated parkinsonism cases with nigral degeneration, over two-thirds demonstrate evidence of pathologic alpha-synuclein, but many do not. Understanding the clinical phenotype and underlying biology in such individuals is critical for therapeutic development. Our objective was to compare biomarker features, rate progression 4 years follow-up, among without vivo alpha-synuclein aggregates. Data were from Parkinson's Progression Markers Initiative, a multicentre prospective...
Abstract LRRK2 gene variants are a major genetic risk factor for both familial and sporadic Parkinson’s disease (PD), opening an unattended window on the disease’s mechanisms potential therapies. Investigating influence of pathogenic in brain structure is crucial step toward enabling early diagnosis personalized treatment. Yet, despite its significance, ways which genotype affects remain largely unexplored. Work this domain plagued by small sample sizes differences cohort composition, can...
As the world’s population ages, neurodegenerative diseases are becoming more widely acknowledged as serious global health and socioeconomic issues. Although many resources have been devoted to research of these illnesses, little progress has made in creation novel diagnostic therapeutic approaches. Extracellular vesicles (EVs) released by all cell types contain proteins, microRNAs, mRNAs, other biologically active molecules. EVs play an important role intercellular communication well...
Objective This study was designed to demonstrate the prognostic value of nutritional index (PNI), a reflection systemic immunonutritional status, on long-term survival patients taking epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs). Methods In this retrospective study, eligible advanced NSCLC with sensitive EGFR mutations (exon 19 deletion or L858R in exon 21) were included investigate correlation between PNI and overall (OS). The calculated as 10 x serum albumin...
INTRODUCTION: Up to 60% of patients with common bile duct stone (CBDS) recurrence suffer from further after endoscopic retrograde cholangiopancreatography (ERCP). There are no effective methods prevent in most patients. In this study, we aimed assess the short-term and long-term efficacies papillary large balloon dilation (EPLBD) for management recurrent CBDS a randomized controlled trial. METHODS: Consecutive were eligible randomly assigned 1:1 ratio EPLBD group or control group. The...
Complement component C4 mediates C3-dependent tissue damage after systemic ischemia—reperfusion injury. Activation of C3 also contributes to the pathogenesis experimental and human traumatic brain injury (TBI); however, few data exist regarding specific pathways (classic, alternative, lectin) involved. Using complement knockout mice a controlled cortical impact (CCI) model, we tested hypothesis that classic pathway secondary TBI. After CCI, C4c C3d immunostaining were detected in vascular...
Mannose binding lectin (MBL) initiates complement activation and exacerbates tissue damage after systemic ischemia/reperfusion. We tested the hypothesis that MBL activates worsens outcome using two levels of controlled cortical impact (CCI) in mice. After moderate CCI (0.6 mm depth), immunostaining was detected on injured endothelial cells wild-type (WT) mice C3d KO (deficient A/C) WT mice, suggesting is dispensable for terminal CCI. Brain neutrophils, edema, blood-brain barrier...
The predictive power of age at diagnosis and smoking history for ALK rearrangements EGFR mutations in non-small-cell lung cancer (NSCLC) remains not fully understood. In this cross-sectional study, 1160 NSCLC patients were prospectively enrolled genotyped EML4-ALK mutations. Multivariate logistic regression analysis was performed to explore the association between clinicopathological features these two genetic aberrations. Receiver operating characteristic (ROC) curves methodology applied...
Migraine is a disabling chronic episodic disorder. Attack frequency progressively increases in some patients. Incremental cortical excitability has been implicated as mechanism underlying progression. Cortical spreading depression (CSD) the electrophysiological event migraine aura, and headache trigger. We hypothesized that CSD events during frequent attacks condition cortex to increase susceptibility further attacks.A single daily was induced for 1 or 2 weeks mouse frontal cortex;...