A5102949432- Spine and Intervertebral Disc Pathology
- Spinal Hematomas and Complications
- Migraine and Headache Studies
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Congenital Anomalies and Fetal Surgery
- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Trauma Management and Diagnosis
- Parasitic infections in humans and animals
- Anesthesia and Pain Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury Research
- Acute Ischemic Stroke Management
- Pituitary Gland Disorders and Treatments
- Nicotinic Acetylcholine Receptors Study
- Neurosurgical Procedures and Complications
- Winter Sports Injuries and Performance
- Case Reports on Hematomas
- Pelvic and Acetabular Injuries
- Adrenal and Paraganglionic Tumors
- Psychosomatic Disorders and Their Treatments
- Dysphagia Assessment and Management
- Organ Donation and Transplantation
- Cardiac Valve Diseases and Treatments
University of Kentucky
2019-2023
Massachusetts General Hospital
2014-2020
Harvard University
2014-2020
UPMC Central Pa
2019
Bam University of Medical Sciences
2016-2017
Beth Israel Deaconess Medical Center
2017
The Neurological Institute
2017
Cleveland Clinic
2017
Sarem Cell Research Center
2013-2014
Tehran University of Medical Sciences
2013
In Brief Vagus nerve stimulation has recently been reported to improve symptoms of migraine. Cortical spreading depression is the electrophysiological event underlying migraine aura and a trigger for headache. We tested whether vagus inhibits cortical explain its antimigraine effect. Unilateral was delivered either noninvasively through skin or directly by electrodes placed around nerve. Systemic physiology monitored throughout study. Both noninvasive transcutaneous invasive direct...
Cortical spreading depolarizations (CSDs) are intense and ubiquitous depolarization waves relevant for the pathophysiology of migraine brain injury. CSDs disrupt blood-brain barrier (BBB), but mechanisms unknown.
Migraine is a chronic and disabling disorder. Treatment of migraine often comprises symptomatic (abortive) preventive (prophylactic) treatment. The current drugs used in prophylaxis include antidepressant (Serotonin Reuptake Inhibitors, Tricyclic antidepressants), anti-epileptic (valproate, gabapentin, etc).The objective our study was to assess the efficacy tolerability levetiracetam adult prophylaxis, compared valproate placebo.We conducted prospective, randomized, placebo-controlled study....
Retrospective study.To evaluate how motor, sensory, and urinary outcomes of spinal cord injury (SCI) patients were influenced in the long term.SCI is a potentially disabling devastating neurological outcome that can occur because column fractures. Most studies have not evaluated or failed to show influence different surgical approaches other parameters on recovery.A thorough history regarding complaints was taken from 103 with SCI due vertebral fracture; followed by examination....
Case-control.Evaluate clinical and imaging factors which may predict the risk of failure medical therapy in patients with lumbar disc herniation (LDH).LDH is a common cause low back pain radicular leg pain, generally favorable natural course. At present, however, it not possible to identify who be candidates for surgery an early stage their disease by means signs or diagnostic criteria.We designed study investigating untreated assess predictive value demographic, findings identifying finally...
Up to 75% of skateboarders and snowboarders admitted the hospital sustain head injuries. It is unclear why not all children teenagers wear helmets while snowboarding skateboarding given protection they afford.
To evaluate risk factors for clinical deterioration in mild traumatic brain injury.Prospective cross-sectional.This study evaluated 203 patients with injury. A computed tomography scan was performed all and they were observed 6-48 hours.Among these patients, 2.5% had cerebral contusions the most common sites frontal lobes; 94% of no hematoma initial scan, while 3% subgaleal haematoma, 1.5% subdural 1% showed subarachnoid haemorrhage, 0.5% intracerebral haemorrhage epidural haemorrhage. GCS...
Abstract Rho‐associated kinase ( ROCK ) is an emerging target in acute ischemic stroke. Early pre‐hospital treatment with inhibitors may improve their efficacy, but antithrombotic effects raise safety concerns hemorrhagic stroke, precluding use prior to neuroimaging. Therefore, we tested whether inhibition affects the bleeding times, and worsens hematoma volume a model of intracerebral hemorrhage ICH induced by intrastriatal collagenase injection mice. Tail time was measured 1 h after...
A hydatid cyst is a zoonotic disease caused by the worm Echinococcus granulosus. In endemic regions, it well-known differential diagnosis of cystic lesions, especially in liver, lungs, brain, and vertebral column. Primary paravertebral muscle involvement, however, rarely reported. current report, we present case an 11-year-old girl complaining back pain with well-defined single lesion her lumbar multifidus evident imaging studies. The patient had no concomitant systemic evaluation. was...
Case series.To present results of conservative management in patients with pure C2 body fractures.Axis fractures, a less common subgroup are commonly classified as vertical coronal, sagittal, and transverse subtypes. While the treatment paradigm for other fractures is clear, there insufficient evidence to support guidelines fractures.Eleven were managed external immobilization followed thereafter.All neurologic examinations normal. In computed tomography (CT) scans, four, two, three, two had...
Because optimal therapeutic strategies vary with tumor type, a histologic diagnosis by either stereotactic or endoscopic biopsy open surgery is the foundation of management decisions.Stereotactic has advantage ease and minimal invasiveness but associated more sampling errors than ( 19), while resection facilitates maximal removal volume diagnostic accuracy.However, all surgical procedures in pineal region, including both surgery, are potentially hazardous (3,11). █ INTRODUCTIONPineal region...
Glioblastoma multiforme (GBM) is a malignant brain tumor with an ominous prognosis. The standard treatment includes maximal safe resection plus adjuvant therapy. Thalamic GBMs, however, are unfavorable for microsurgical removal because of deep location and proximity to critical structures. We present patient presenting progressive hemiparesis decreased consciousness large thalamic GBM who underwent subtotal through transsylvian approach. His clinical neurologic condition improved after...
Introduction Brain death (BD) is the irreversible termination of functioning brain. The diagnosis should be first made by clinical criteria and confirmed using paraclinical confirmatory techniques (ancillary tests). While conventional brain angiography remains standard method choice, computed tomography (CTA) has emerged as an alternative method. In this study, we tried to evaluate accuracy CTA for BD. Methods included nine patients with a BD, electroencephalography (EEG). was then performed...
The aberrant right subclavian artery (ARSA) is a rare cause of dysphagia. Surgical intervention has remained the mainstem therapy, accompanied with certain morbidities and mortalities. Although rarely reported in literature, endoscopic dilation may be considered suitable treatment alternative patients who are not surgical candidate or do consent for surgery. We report case suffering from dysphagia diagnosed ARSA treated by dilation.A 52-year-old male presented to our clinic 2015 Chest...
Abstract Objectives Spreading depolarizations (SD) likely manifest as aura in migraineurs. Triggers are unknown although vascular events have been implicated. Direct carotid puncture has reported to trigger migraine with aura. The potent vasoconstrictor endothelin-1 (ET-1), which can be released from the endothelium under pathological conditions, may play a role. Here, we tested whether intracarotid ET-1 infusion triggers SD and systemic increases susceptibility SD. Methods Carotid infusions...
Prospective study.